Complete Genome Sequences of Nine Enterovirus D68 Strains from Patients of the Lower Hudson Valley, New York, 2016

Huang, Weihua; Yin, Changhong; Zhuge, Jian; Farooq, Taliya; Yoon, Esther; Nolan, Sheila M.; Chen, Donald; Fallon, John T.; Wang, Guiqing

doi:10.1128/genomea.01394-16

Cited by 8 publications

(9 citation statements)

References 7 publications

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“…The same results were obtained with this study, suggesting that all the 2016 European outbreaks originated from a common source and that the B3 clade has emerged and become preeminent, eclipsing clades A and clades B1 and B2. The worldwide importance of clade B3 appears to be confirmed by the evidence that outbreaks of infections due to EV-D68 infection belonging to clade B3 have been reported in 2015 in China [34], and almost simultaneously with the European epidemics, in the USA [35].…”

Section: Discussionmentioning

confidence: 88%

Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

Piralla

Principi

Ruggiero

et al. 2018

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 88%

Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

Piralla

Principi

Ruggiero

et al. 2018

Journal of Clinical Virology

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“…The sequence was a perfect match to several 2016 genomes from an outbreak in the Lower Hudson Valley, New York in 2016 (18), including NY230_16 (accession no. KY385890, positions 6862 to 6993), NY172_16, NY141_16, and NY135_16, and other genomes, including NY75_16 (85) and USA/TX/2016-19506, and USA/FL/2016-19504 (52). These latter two genomes were isolated from confirmed AFM cases (52).…”

Section: Resultsmentioning

confidence: 99%

Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role

Bowers

Valentine

Harrison

et al. 2019

mBio

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Enteroviruses frequently result in respiratory and gastrointestinal illness; however, multiple subtypes, including poliovirus, can cause severe neurologic disease. Recent biennial increases (i.e., 2014, 2016, and 2018) in cases of non-polio acute flaccid paralysis have led to speculations that other enteroviruses, specifically enterovirus D68 (EV-D68), are emerging to fill the niche that was left from poliovirus eradication. A cluster of 11 suspect cases of pediatric acute flaccid myelitis (AFM) was identified in 2016 in Phoenix, AZ. Multiple genomic analyses identified the presence of EV-D68 in the majority of clinical AFM cases. Beyond limited detection of herpesvirus, no other likely etiologies were found in the cluster. These findings strengthen the likelihood that EV-D68 is a cause of AFM and show that the rapid molecular assays developed for this study are useful for investigations of AFM and EV-D68.

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“…Nine of these from our first NGS run were published recently 36 . Additional 13 were assembled from two subsequent NGS runs.…”

Section: Resultsmentioning

confidence: 99%

Enterovirus D68 Subclade B3 Strain Circulating and Causing an Outbreak in the United States in 2016

Wang

Zhuge

Huang

et al. 2017

Sci Rep

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In 2014 the United States experienced a nationwide outbreak of Enterovirus D68 (EV-D68) infection. There were no confirmed cases of EV-D68 in 2015 and CDC was only aware of limited sporadic EV-D68 detection in the US in 2016. In this report, we analyzed 749 nasopharyngeal (NP) specimens collected in 2015 and 2016 from patients in the Lower Hudson Valley, New York using a previously validated EV-D68-specific rRT-PCR assay. EV-D68 was detected in none of 199 NP specimens collected in 2015, and in one of 108 (0.9%) samples from January to May and 159 of 442 (36.0%) samples from July to October 2016. Complete EV-D68 genome sequences from 22 patients in 2016 were obtained using a metagenomic next-generation sequencing assay. Comparative genome analysis confirmed that a new EV-D68 strain belonging to subclade B3, with 3.2–4.8% divergence in nucleotide from subclade B1 strains identified during the 2014 US outbreak, was circulating in the US in 2016 and caused an outbreak in the Lower Hudson Valley, New York with 160 laboratory-confirmed cases. Our data highlight the genetic variability and capacity in causing outbreak by diverse EV-D68 strains, and the necessity of awareness and more surveillance on their active circulation worldwide.

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Complete Genome Sequences of Nine Enterovirus D68 Strains from Patients of the Lower Hudson Valley, New York, 2016

Cited by 8 publications

References 7 publications

Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy

Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role

Enterovirus D68 Subclade B3 Strain Circulating and Causing an Outbreak in the United States in 2016

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