Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products

Ma, Liang; Zhang, Wenjun; Liu, Zhiwen; Huang, Yanbing; Zhang, Qingbo; Tian, Xinpeng; Zhu, Yiguang

doi:10.1016/j.margen.2020.100803

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…The structural elucidation was investigated by spectroscopic analysis and supported by X-ray crystallography. Bioactivity assays revealed moderate antiproliferative activities (human glioma U251 and U87MG cells, IC 50 Further studies and recent publications highlight the importance of these bisindole alkaloids as promising bioactive compounds and potential new lead structures [153,154].…”

Section: Scheme 12mentioning

confidence: 94%

“…Further studies and recent publications highlight the importance of these bisindole alkaloids as promising bioactive compounds and potential new lead structures [ 153 , 154 ].…”

Section: Non-halogenated Marine Pyrrole Alkaloidsmentioning

confidence: 99%

“…After the final deprotection, (±)-spiroindimicin C (157) could be obtained. Additionally, reductive amination furnished (±)-spiroindimicin B ( 156 Further studies and recent publications highlight the importance of these bisindole alkaloids as promising bioactive compounds and potential new lead structures [153,154].…”

Section: Scheme 12mentioning

confidence: 99%

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Marine Pyrrole Alkaloids

2021

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Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

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Section: Scheme 12mentioning

confidence: 94%

“…Further studies and recent publications highlight the importance of these bisindole alkaloids as promising bioactive compounds and potential new lead structures [ 153 , 154 ].…”

Section: Non-halogenated Marine Pyrrole Alkaloidsmentioning

confidence: 99%

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Marine Pyrrole Alkaloids

2021

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“…The closest taxonomic relatives reported for isolate MA3_2.13 were Streptomyces sp. SCSIO 3032 (GenBank Assembly accession GCA_002128305 [28]; p-value: 0.91) with 67.47% average amino acid identity (AAI) and Streptomyces harbinensis NA02264 (GenBank assembly accession GCA_013364095; p-value: 0.926) with 66.31% AAI. The results further suggest that isolate MA3_2.13 belongs to the Streptomyces genus (p-value: 0.34), although likely to a species not represented in the NCBI database (p-value: 0.0021).…”

Section: Phylogenetic Analysis Of the Deep-sea Isolated Strainsmentioning

confidence: 99%

“…The results from the MiGA server matched with the KmerFinder best scores obtained for both isolates: Streptomyces sp. SCSIO 03032 (score = 4924), isolated from deep-sea sediment from the Indian Ocean [28] for isolate MA3_2.13 and Streptomyces xinghaiensis S187 (score = 63,434) for isolate S07_1. 15.…”

Section: Phylogenetic Analysis Of the Deep-sea Isolated Strainsmentioning

confidence: 99%

Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential

et al. 2021

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The deep-sea constitutes a true unexplored frontier and a potential source of innovative drug scaffolds. Here, we present the genome sequence of two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from deep-sea samples (sediments and sponge) and collected at Madeira archipelago (NE Atlantic Ocean; Portugal). The de novo assembly of both genomes was achieved using a hybrid strategy that combines short-reads (Illumina) and long-reads (PacBio) sequencing data. Phylogenetic analyses showed that strain MA3_2.13 is a new species of the Streptomyces genus, whereas strain S07_1.15 is closely related to the type strain of Streptomyces xinghaiensis. In silico analysis revealed that the total length of predicted biosynthetic gene clusters (BGCs) accounted for a high percentage of the MA3_2.13 genome, with several potential new metabolites identified. Strain S07_1.15 had, with a few exceptions, a predicted metabolic profile similar to S. xinghaiensis. In this work, we implemented a straightforward approach for generating high-quality genomes of new bacterial isolates and analyse in silico their potential to produce novel NPs. The inclusion of these in silico dereplication steps allows to minimize the rediscovery rates of traditional natural products screening methodologies and expedite the drug discovery process.

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Streptomyces Endophytes in Edible Plants: New Insights into their Chemistry and Health Benefits

Moussa

2024

Chemistry & Biodiversity

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Streptomyces is the largest source of microbial antibiotics with about 50% of marketed antimicrobial drugs originating from this genus. Endophytic streptomyces are the link between medicinal plants and the microbial world. Edible plants endophytic streptomyces were not targeted before despite their uniqueness and importance. In this review, we analyzed the chemical diversity of more than 150 compounds belonging to endophytic Streptomyces chemical classes such as alkaloids, polyketides, peptides, macrolides and terpenes and their biological activities. This analysis showed a dominant antimicrobial effect for most of the isolated compounds and highlighted an underestimated diversity to be studied or repurposed for other biological activities. Return to edible plants use and conducting toxicity studies to rationalize their nutraceutical potential based on their beneficial endophytes is urged. Although there are many studies for non‐vertebrates, the nutraceutical potential of these plants is expected to improve the gut microbiota since they are enriched with bioactive compounds from streptomyces species. This is the first review to discuss edible plants associated streptomyces, and we prospect that many studies will follow to unravel the mysterious health benefits of streptomyces in the human microbiome and encourage the revival of a correct lifestyle for the sack of a healthier microbiome.

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Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products

Cited by 10 publications

References 24 publications

Marine Pyrrole Alkaloids

Marine Pyrrole Alkaloids

Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential

Streptomyces Endophytes in Edible Plants: New Insights into their Chemistry and Health Benefits

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