Complete Genome Sequence of Micrococcus yunnanensis TT9, Isolated from a Healthy Volunteer

Choi, Younshil; Son, Haelim; Lee, Kyoung

doi:10.1128/mra.00652-22

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“…[2,3] Recently, Lee et al reported the complete genome sequence of M. yunnanensis TT9 obtained from the skin of the forehead of a healthy volunteer. [4] M. yunnanensis has been characterized as a nonpathogenic organism that shows no external signs of infection in its host. Most studies have focused on the role of M. yunnanensis in industrial wastewater treatment and plant growth promoting activities, [5][6][7] little is known about its role in the medical field.…”

Section: Introductionmentioning

confidence: 99%

First case report of human infection with Micrococcus yunnanensis identified by 16S rRNA gene sequencing: A case report

et al. 2022

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Background: Micrococcus yunnanensis (M. yunnanensis) is an endophytic actinomycete that was originally isolated from the roots of Polyspora axillaris in 2009, and no human infections caused by this organism have yet been reported. We report the first case of community-acquired pneumonia caused by M. yunnanensis and propose that M. yunnanensis should be considered as an emerging pathogen in medical practice. A 30-year-old woman was admitted to our hospital with fever, paroxysmal dry cough with sputum, and pharyngalgia. Laboratory tests revealed an increase in several inflammatory indicators, and a computerized tomography scan of the chest showed scattered infection foci in both lungs. Bronchoalveolar lavage fluid was collected via bronchoscopy for microbial culture and pathological examination.Methods: The isolate from bronchoalveolar lavage fluid was identified as M. yunnanensis by 16S rRNA gene sequencing. The patient was diagnosed with community-acquired pneumonia based on the diagnostic criteria.Results: The patient was treated with intravenous amoxicillin/clavulanate potassium, levofloxacin hydrochloride tablets, and compound methoxyphenamine capsules on the day after admission. After 3 days of treatment, the patient's physiological conditions and inflammatory indicators normalized, and 6-month follow-up showed no abnormalities. Conclusion:Although the pathogenicity of M. yunnanensis is unclear, the present case indicates an emerging pathogen in medical practice. MALDI-TOF MS has a limited ability to identify novel or rare pathogenic species, and 16S rRNA gene sequencing is of great value in some circumstance.Abbreviations: AST = antimicrobial susceptibility test, BALF = bronchoalveolar lavage fluid, MALDI-TOF MS = matrix-assisted laser desorption ionization/time of flight mass spectrometry.

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Section: Introductionmentioning

confidence: 99%

First case report of human infection with Micrococcus yunnanensis identified by 16S rRNA gene sequencing: A case report

et al. 2022

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Complete Genome Sequence of Micrococcus yunnanensis TT9, Isolated from a Healthy Volunteer

Abstract: Micrococcus yunnanensis TT9 was isolated from the forehead of human skin. This strain can grow on Triton X-100. We report the complete whole-genome sequence of this strain, which has one chromosome of 2,470,932 bp (73.0% G+C content) with 2,151 coding sequences.

Cited by 1 publication

References 10 publications

First case report of human infection with Micrococcus yunnanensis identified by 16S rRNA gene sequencing: A case report

First case report of human infection with Micrococcus yunnanensis identified by 16S rRNA gene sequencing: A case report

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