Complete Genome Sequence of Mayaro Virus Imported from the Amazon Basin to São Paulo State, Brazil

Mota, Mânlio Tasso Oliveira; Vedovello, Danila; Estofolete, Cássia Fernanda; Malossi, Camila Dantas; Araújo, João Pessoa; Nogueira, Maurício Lacerda

doi:10.1128/genomea.01341-15

Cited by 22 publications

(17 citation statements)

References 3 publications

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“…No mortality is associated with MAYV infection, but the illness can cause significant morbidity among rural population, 125 including intense arthralgia, temporary incapacitation to work, and hospitalization. Few cases are described in some subpopulations, especially the immunocompromised group, and are showed to be imported cases 126 . Hemorrhagic manifestations in MAYV infections have been described, although rare 127 …”

Section: Alphavirusmentioning

confidence: 99%

Mosquito-transmitted viruses – the great Brazilian challenge

Mota

Terzian

Silva

et al. 2016

Brazilian Journal of Microbiology

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Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus.In Brazil, dengue is endemic, along with the presence of other arboviruses. The situation is complicated by the scarcity of diagnostic infrastructure and the absence of approved vaccines for these diseases. Disease control, thus, relies solely on vector control. Therefore, enhanced clinical knowledge and improved general awareness about these arboviruses are indispensable to tackle diagnostic inadequacies.

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Section: Alphavirusmentioning

confidence: 99%

Mosquito-transmitted viruses – the great Brazilian challenge

Mota

Terzian

Silva

et al. 2016

Brazilian Journal of Microbiology

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“…www.nature.com/scientificreports www.nature.com/scientificreports/ Methods Viral protein sequences. We carried out the bioinformatic analysis using protein sequences available for the clinical isolates of alphaviruses known to cause polyarthralgia [30][31][32][33] and used as protype strains in the literature 29 . Structural polyproteins of the six arthritogenic alphaviruses: Chikungunya virus (strain S2-African www.nature.com/scientificreports www.nature.com/scientificreports/ prototype)(UniProt ID: Q8JUX5), the Ross river virus (strain NB5092) (UniProt ID: P13890), the Semliki forest virus (UniProt ID: P03315), the Mayaro virus (strain Brazil) (UniProt ID: Q8QZ72), the O'nyong-nyong virus (strain SG650) (UniProt ID: O90369) and the Barmah forest virus (UniProt ID: P89946) were investigated for the presence of conserved regions.…”

Section: Discussionmentioning

confidence: 99%

A possible role for autoimmunity through molecular mimicry in alphavirus mediated arthritis

Venigalla

Premakumar

Vani

2020

Sci Rep

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Alphaviral infections are foremost in causing debilitating clinical outcomes in humans characterized by rheumatic arthritis like conditions. Though the presence of virus in joints and associated inflammation has been implicated as one of the reasons for the acute and chronic polyarthritis post alphaviral infections, the basis for rheumatic like outcomes is not clear. through an in silico analysis, we have investigated the possibility of an autoimmune process mediated through molecular mimicry in alphaviral infection induced pathogenicity. interestingly, sequence alignment of the structural polyproteins belonging to arthritogenic alphaviruses revealed conserved regions which share homology with human proteins implicated in rheumatoid arthritis (RA). these conserved regions were predicted to exhibit binding to HLA class ii alleles, showcasing their potential to incite t cell help. Molecular docking of the viral peptide and the corresponding homologous region in the human protein onto HLA-DRB1 revealed strong similarities in their binding patterns. Linear and conformational B cell epitope prediction analyses showed that these potential mimics have high propensity to elicit an efficient B cell response. We thus propose that the origin of polyarthritis post-arthritogenic alphaviral infections may also be mediated through a hitherto unknown autoimmune response due to the presence of crossreactive epitopes between viral and human proteins. Alphaviruses belonging to the group IV togoviridae family are positive sense, single stranded RNA viruses. These enveloped viruses are classified as old world and new world. While new world viruses are encephalitogenic, members of the old world are known to induce polyarthritis 1. The members of the old world viruses include Chikungunya Virus (CHIKV), Ross River Virus (RRV), Mayaro Virus (MAYV), O'nyong nyong virus (ONV), Semiliki Forest Virus (SFV) and the Barmah Forest Virus (BFV). These mosquito transmitted viruses are globally distributed and are known to cause acute febrile illnesses, malaise, maculopapular rashes, myalgia, and severe arthralgia in humans 2-5. Most often the infection remains endemic, but some viral strains are also associated with large epidemics such as the Chikungunya virus (CHIKV) outbreak which was spread across 40 countries with 1.4-6.5 million reported cases globally 6. Several studies also report a simultaneous increase in alpha virus associated arthritis lasting even after decrease in viral load 7. While there is a resurgence of alphavirus associated arthritis cases, the knowledge about the molecular level events during infections involved in these conditions and about the direct cause and effect of the phenomenon is very sparse. For instance, macrophages, natural killer cells, CD4+ and CD8+ T lymphocytes have been shown as the main components of the inflammatory cellular infiltrate in animal models of CHIKV and RRV infections 8-10. Production of a broad range of pro-inflammatory cytokines (IL-6, TNF, IFN-α/β, and IFNγ) and chemokines (MCP-1 and RANTES) ...

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“…Viral fevers are endemic in low socioeconomic areas and, subsequently, smaller investments are made in research, surveillance, and investigation of epidemics; many studies on arboviruses merely describe cases. Furthermore, this virus causes a dengue-like febrile syndrome with arthralgia/ arthritis and the diagnosis relies only on clinical manifestations (7) : what seems like dengue must be dengue. Diagnosis based only on clinical findings may lead to misdiagnosis of MAYV as DENV or other viruses, resulting in underestimation of MAYV infections.…”

Section: Discussionmentioning

confidence: 99%

“…The virus was directly sequenced from the patient serum using Next Generation Sequencing in an Ilumina Platform (Illumina, San Diego, CA, USA). The genome was submitted to GenBank, named MAYV BR/SJRP/01/2014 (accession number: KT818520.1) (7) . Phylogenetic reconstruction was performed with MEGA v.6.0 (Figure 2).…”

Section: Case Reportmentioning

confidence: 99%

Mayaro fever in an HIV-infected patient suspected of having Chikungunya fever

Estofolete

Mota

Vedovello

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Arboviruses impose a serious threat to public health services. We report a case of a patient returning from a work trip to the Amazon basin with myalgia, arthralgia, fever, and headache. During this travel, the patient visited riverside communities. Both dengue and Chikungunya fevers were first suspected, tested for, and excluded. Mayaro fever was then confirmed by reverse transcription polymerase chain reaction followed by next-generation sequencing and phylogenetic reconstruction. The increased awareness of physicians and consequent detection of Mayaro virus in this case was only possible due a previous surveillance program with specific health personnel training about these neglected arboviruses.

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Complete Genome Sequence of Mayaro Virus Imported from the Amazon Basin to São Paulo State, Brazil

Cited by 22 publications

References 3 publications

Mosquito-transmitted viruses – the great Brazilian challenge

Mosquito-transmitted viruses – the great Brazilian challenge

A possible role for autoimmunity through molecular mimicry in alphavirus mediated arthritis

Mayaro fever in an HIV-infected patient suspected of having Chikungunya fever

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