Complete Genome Sequence of Fowl Aviadenovirus Serotype 8b Isolated in South America

Izquierdo-Lara, Ray; Calderón, Katherine; Chumbe, Ana; Montesinos, Ricardo; Montalván, Ángela; González, Armando E.; Icochea, Eliana; Fernández-Díaz, Manolo

doi:10.1128/genomea.01174-16

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…FAdV strains sequenced in this study were either isolated from documented clinical cases, or purchased from the American Type Culture Collection (Manassas, VA), as well as kindly supplied by H. M. Hafez (Institute of Poultry Diseases, Berlin, Germany) and Vaxxinova Japan K.K. (Tokyo, Japan) ( Supplementary Table S1) [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Besides FAdV-D and FAdV-E strains, we sequenced further strains of species FAdV-A (including the hitherto unavailable OTE reference genome) and FAdV-C (including, for the first time, the complete FAdV-10 genome), in order to increase robustness of the analysis.…”

Section: Virus Strains and Dna Preparationmentioning

confidence: 99%

Fowl Adenovirus (FAdV) Recombination with Intertypic Crossovers in Genomes of FAdV-D and FAdV-E, Displaying Hybrid Serological Phenotypes

Schachner

González

Endler

et al. 2019

Viruses

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After analyzing 27 new genomes from fowl adenovirus (FAdV) field isolates and so-far unsequenced prototypes, we report the first evidence for recombination in FAdVs. Recombination was confined to species FAdV-D and FAdV-E, accommodating the largest number of, and the intraspecies-wise most differentiated, types. The majority of detected events occurred in FAdV-E, involving segments with parental origin of all constitutive types. Together with the diversity of breakpoints, this suggests widespread recombination in this species. With possible constraints through species-specific genes and diversification patterns, the recombinogenic potential of FAdVs attains particular interest for inclusion body hepatitis (IBH), an important disease in chickens, caused by types from the recombination-prone species. Autonomously evolving, recombinant segments were associated with major sites under positive selection, among them the capsid protein hexon and fiber genes, the right-terminal ORFs 19, 25, and the ORF20/20A family. The observed mosaicism in genes indicated as targets of adaptive pressures points toward an immune evasion strategy. Intertypic hexon/fiber-recombinants demonstrated hybrid neutralization profiles, retrospectively explaining reported controversies on reference strains B3-A, T8-A, and X11-A. Furthermore, cross-neutralization supported sequence-based evidence for interdomain recombination in fiber and contributed to a tentatively new type. Overall, our findings challenge the purported uniformity of types responsible for IBH, urging more complete identification strategies for FAdVs. Finally, important consequences arise for in vivo studies investigating cross-protection against IBH.

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Section: Virus Strains and Dna Preparationmentioning

confidence: 99%

Fowl Adenovirus (FAdV) Recombination with Intertypic Crossovers in Genomes of FAdV-D and FAdV-E, Displaying Hybrid Serological Phenotypes

Schachner

González

Endler

et al. 2019

Viruses

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“…There has been an increase in reports of HHS and IBH outbreaks from various regions in the last ten years, such as in Europe [41][42][43][44], Asia [45][46][47][48][49], Oceania [30], North America [50], South America [51,52], and Africa [53,54], indicating even geographical spread of FAdVs. As in most Asian countries, FAdV-induced outbreaks in poultry have been observed in South Korea for many years, and, to date, these outbreaks persist.…”

Section: Introductionmentioning

confidence: 99%

Historical Investigation of Fowl Adenovirus Outbreaks in South Korea from 2007 to 2021: A Comprehensive Review

2021

Viruses

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Fowl adenoviruses (FAdVs) have long been recognized as critical viral pathogens within the poultry industry, associated with severe economic implications worldwide. This specific group of viruses is responsible for a broad spectrum of diseases in birds, and an increasing occurrence of outbreaks was observed in the last ten years. Since their first discovery forty years ago in South Korea, twelve antigenically distinct serotypes of fowl adenoviruses have been described. This comprehensive review covers the history of fowl adenovirus outbreaks in South Korea and updates the current epidemiological landscape of serotype diversity and replacement as well as challenges in developing effective broadly protective vaccines. In addition, transitions in the prevalence of dominant fowl adenovirus serotypes from 2007 to 2021, alongside the history of intervention strategies, are brought into focus. Finally, future aspects are also discussed.

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“…A recent publication on the molecular characterization of disease causing FAdV strains from Brazil revealed the presence of FAdV-8a, FAdV-8b and FAdV-11 (De la Torre, Nunez, Parra, Astolfi-Ferreira, & Ferreira, 2018). Serotype 8b was also identified from an outbreak of IBH in chickens from Peru in 2016 (Izquierdo-Lara et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Identification of four serotypes of fowl adenovirus in clinically affected commercial poultry co‐infected with chicken infectious anaemia virus in Trinidad and Tobago

Jordan

Blake

Bisnath³

et al. 2019

Transbound Emerg Dis

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Summary Fowl adenovirus (FAdV), which causes the high‐impact diseases such as inclusion body hepatitis and hepatitis‐hydropericardium syndrome, is of major concern to the poultry industry internationally. This study was carried out in direct response to mortality rates of up to 75% in commercial broiler flocks in Trinidad, West Indies. Symptoms in 3‐ to 8‐week‐old broilers and 13‐ to 18‐week‐old pullets pointed to infection with an immunosuppressive viral pathogen. The objectives of the study were to determine whether the infectious agent FAdV, along with other viral pathogens, was responsible for the clinical disease, and to obtain information on the serotypes of FAdV that were infecting the birds. Tissue samples from clinically affected birds from eight different farms were tested for chicken infectious anaemia virus (CIAV) and infectious bursal disease virus (IBDV) by real‐time reverse transcription polymerase chain reaction (PCR) and for FAdV by conventional PCR. The birds tested positive for FAdV and CIAV, but negative for IBDV. The gene corresponding to the L1 loop of the hexon protein for FAdV was amplified and sequenced. Phylogenetic analysis of seven FAdV strains inferred that four serotypes were likely to be circulating in the chickens. Well supported genetic relatedness was observed for serotype 8a (97.8%), 8b (97.8%), 9 (95.8%) and 11 (98.8%–99.5%). This is the first published report from Trinidad and Tobago on the presence and circulation of pathogenic FAdV strains, in combination with CIAV, in poultry. The data demonstrate a possible need for the introduction of serotype‐specific vaccines against FAdV, as well as vaccines against CIAV, in broilers in the region and emphasize the importance of maintaining high levels of biosecurity on farms to prevent the spread of these potentially devastating viruses between farms.

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Complete Genome Sequence of Fowl Aviadenovirus Serotype 8b Isolated in South America

Cited by 8 publications

References 6 publications

Fowl Adenovirus (FAdV) Recombination with Intertypic Crossovers in Genomes of FAdV-D and FAdV-E, Displaying Hybrid Serological Phenotypes

Fowl Adenovirus (FAdV) Recombination with Intertypic Crossovers in Genomes of FAdV-D and FAdV-E, Displaying Hybrid Serological Phenotypes

Historical Investigation of Fowl Adenovirus Outbreaks in South Korea from 2007 to 2021: A Comprehensive Review

Identification of four serotypes of fowl adenovirus in clinically affected commercial poultry co‐infected with chicken infectious anaemia virus in Trinidad and Tobago

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