Complete Genome Sequence of Canine Papillomavirus Type 16

Luff, Jennifer; Mader, Michelle; Britton, Monica; Fass, Joseph; Rowland, Peter H.; Orr, Carolyn; Schlegel, Richard; Yuan, Hang

doi:10.1128/genomea.00404-15

Cited by 16 publications

(22 citation statements)

References 9 publications

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“…All nine PVs (CPV‐3,‐4,‐5, ‐8, ‐9, ‐10, ‐11, ‐12, ‐14, and ‐16) that have been amplified from pigmented plaques in dogs belong to the Chi‐papillomavirus genus (Rector & Van Ranst ; Luff et al . ).…”

Section: Discussionmentioning

confidence: 97%

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Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Hansen

Nicholas²,

Pack³

et al. 2017

Veterinary Medicine & Sci

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Cutaneous pigmented viral plaques is a disorder of epidermal growth caused by canine papillomavirus type 4 (CPV‐4). There is currently no standard of care for managing this condition and it has not been reported in the Hungarian Vizsla. This case series documents the clinical features of canine pigmented viral plaques in Hungarian Vizsla dogs and the treatment of a severe case using a novel topical agent tigilanol tiglate (EBC‐46). A 4‐year‐old spayed Hungarian Vizsla in Australia was presented for multiple cutaneous pigmented plaques extending from the ventral cervical region. Lesions were neither painful nor pruritic. The number and size of these sessile plaques increased over time, with the largest lesions eventually taking on an exophytic (wart‐like) appearance. These lesions did not affect the dog's wellbeing. Two much less severe cases in a 5‐year‐old Vizsla from the UK and a 7‐year‐old Vizsla from New Zealand were also diagnosed. Histology was consistent with papillomavirus‐induced pigmented plaques and CPV‐4 DNA sequences were amplified from paraffin‐embedded formalin‐fixed tissue using the polymerase chain reaction from the most severely affected patient. Topical imiquimod was ineffective although used for only a short time. Two topical applications of novel anti‐neoplastic diterpene ester tigilanol tiglate as a gel, 9 days apart, greatly reduced the size and number of lesions in a limited portion of skin treated, over the lateral hock. While CPV‐4 has been previously reported to cause pigmented plaques, most commonly on pug dogs, but sporadically on other breeds, this is the first report of this virus causing plaques in Hungarian Vizslas. The cases illustrate some of the difficulties in diagnosing papillomavirus‐induced disease in dogs, especially in its early stages. Topical tigilanol tiglate is a potentially useful topical therapy for this viral‐induced disorder of cell growth and represents a treatment deserving of further investigation.

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Section: Discussionmentioning

confidence: 97%

“…inverted papillomas), canine pigmented plaques tend to occur in older dogs and do not to spontaneously regress. All nine PVs that have been amplified from pigmented plaques in dogs belong to the Chipapillomavirus genus (Rector & Van Ranst 2013;Luff et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Hansen

Nicholas²,

Pack³

et al. 2017

Veterinary Medicine & Sci

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“…Canine papillomaviruses belonging to the Chi genus seem to show a cutaneous tropism and are largely associated with pigmented plaques, with only a minority of virus types being identified in malignant lesions (Tobler et al., ; Luff et al., , ). Recently, CPV12 and CPV16 were identified in viral plaques from two Basenji dogs, which progressed to metastatic SCC (Luff et al., ).…”

Section: Papillomavirus In Companion Animals: Which Viruses Cause Whimentioning

confidence: 99%

“…Seventeen CPV types have been proposed and grouped into genera Lambdapapillomavirus (CPV1 and 6), Taupapillomavirus (CPV2, 7, 13 and 17) and Chipapillomavirus (CPV3,4,5,8,9,10,11,12,14,15 and 16) (Table 1). CPV1, long known as the canine oral papillomavirus (CoPV), is associated with oral papillomatosis (Porcellato et al, 2014;Sancak et al, 2015), together with Pigmented plaques, cutaneous SCC NC_026640 Luff et al (2015Luff et al ( , 2015 SCC, squamous cell carcinoma; XSCID,X-linked combined severe immunodefficient.…”

Section: Papillomavirus In Companion Animals: Which Viruses Cause Whimentioning

confidence: 99%

“…Still, while oral SCC appear to be rarely caused by papillomavirus infection, one dog was reported to develop multiple oral SCCs associated with infection by the recently detected CPV-17 (Munday et al, 2015d. Canine papillomaviruses belonging to the Chi genus seem to show a cutaneous tropism and are largely associated with pigmented plaques, with only a minority of virus types being identified in malignant lesions (Tobler et al, 2006;Luff et al, 2015Luff et al, , 2016. Recently, CPV12 and CPV16 were identified in viral plaques from two Basenji dogs, which progressed to metastatic SCC (Luff et al, 2016).…”

Section: Papillomavirus In Companion Animals: Which Viruses Cause Whimentioning

confidence: 99%

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An Update on Canine, Feline and Bovine Papillomaviruses

Costa

Peleteiro

Pires

et al. 2016

Transbound Emerg Dis

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Over recent years, a growing number of papillomaviruses have been identified, which cause a wide range of lesions in domestic and wild animals. Papillomavirus-induced lesions may have a great impact on animal health, and some diseases observed in farm animals are associated with significant economic losses. This concise review brings together recent advancements on animal papillomavirus research, providing the scientific community and veterinary practitioners with an update on this rapidly evolving field. Among others, bovine, canine and feline papillomaviruses (BPV, CPV and FcaPV) are most extensively discussed, in view of the recent discovery of new viral types and their worldwide importance for animal health. Feline papillomaviruses 2 is an emerging, highly prevalent pathogen in domestic cats, associated with a subset of malignant skin lesions. Aspects related to cross-species infection by BPV and its environmental co-factors are also addressed. Animal papillomaviruses are also fascinating models for studying molecular and cell biology and have recently inspired some major breakthroughs. Overall, it is clear that additional, international and systematic efforts are needed to clarify which lesions are caused by which viral types and to develop experimental models for studying animal papillomavirus.

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Canine papillomavirus type 16 associated to squamous cell carcinoma in a dog: virological and pathological findings

et al. 2020

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Papillomaviruses (PVs) are circular double-stranded DNA virus belonging to Papillomaviridae family. During the infection cycle, PVs translate proteins that can influence cell growth and differentiation, leading to epidermal hyperplasia and papillomas (warts) or malignant neoplasms. Canis familiaris papillomaviruses (CPVs) have been associated with different lesions, such as oral and cutaneous papillomatosis, pigmented plaques, and squamous cell carcinomas (SCCs). Here, we report a clinical case of a mixed bred female dog with pigmented plaques induced by CPV16 (Chipapillomavirus 2) that progressed to in situ and invasive SCCs. Gross and histological findings were characterized, and the lesions were mainly observed in ventral abdominal region and medial face of the limbs. In situ hybridization (ISH) revealed strong nuclear hybridization signals in the neoplastic epithelial cells, as well as in the keratinocytes and koilocytes of the pigmented viral plaques. The full genome of the CPV16 recovered directly from the lesions was characterized, and the phylogenetic relationships were determined. The identification of oncoprotein genes (E5, E6, and E7) by high throughput sequencing (HTS) and their expected domains are suggestive of the malignant transformation by CPV16.

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Complete Genome Sequence of Canine Papillomavirus Type 16

Cited by 16 publications

References 9 publications

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

An Update on Canine, Feline and Bovine Papillomaviruses

Canine papillomavirus type 16 associated to squamous cell carcinoma in a dog: virological and pathological findings

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