Complete Genome Sequence of Burkholderia gladioli Myophage Mana

Godoy, Brenda; Yao, Guichun; Le, Tram; Vizoso-Pinto, María Guadalupe; Gill, Jason J.; Gonzalez, Carlos F.; Liu, Mei

doi:10.1128/mra.00402-21

Cited by 1 publication

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the genus Burkholderia, in 2021, Godoy et al [69] reported the genome sequence of a P2-like phage of Burkholderia gladioli, a ubiquitous Gram-negative with a recognized ability to infect pwCF. The phage was isolated from soil and sequenced to characterize its main features, in order to advance knowledge on alternative treatments for B. gladioli infections.…”

Section: B Cepacia Complexmentioning

confidence: 99%

New Antimicrobial Strategies to Treat Multi-Drug Resistant Infections Caused by Gram-Negatives in Cystic Fibrosis

Scoffone,

Barbieri,

Irudal

et al. 2024

Antibiotics

View full text Add to dashboard Cite

People with cystic fibrosis (CF) suffer from recurrent bacterial infections which induce inflammation, lung tissue damage and failure of the respiratory system. Prolonged exposure to combinatorial antibiotic therapies triggers the appearance of multi-drug resistant (MDR) bacteria. The development of alternative antimicrobial strategies may provide a way to mitigate antimicrobial resistance. Here we discuss different alternative approaches to the use of classic antibiotics: anti-virulence and anti-biofilm compounds which exert a low selective pressure; phage therapies that represent an alternative strategy with a high therapeutic potential; new methods helping antibiotics activity such as adjuvants; and antimicrobial peptides and nanoparticle formulations. Their mechanisms and in vitro and in vivo efficacy are described, in order to figure out a complete landscape of new alternative approaches to fight MDR Gram-negative CF pathogens.

show abstract

Section: B Cepacia Complexmentioning

confidence: 99%