Complete Genome Sequence of Avian Coronavirus Strain D274

Brandão, Paulo Eduardo; Hora, Aline Santana da; Silva, Sheila O. S.; Berg, Mikael; Taniwaki, Sueli Akemi

doi:10.1128/mra.01003-18

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…More recently, genetic studies have suggested recombination events of circulating IBV in Peru and Uruguay, which might reveal the underlying events of viral evolution occurring in South American countries [ 11 , 12 ]. Furthermore, IBV GI-1 lineage has been detected in countries, such as Brazil [ 13 , 14 , 15 , 16 ], Argentina [ 9 ], Chile [ 17 , 18 ], and Colombia [ 19 ]. Although its first detection in South America dated back to 1950s [ 20 ], it is possible that circulating GI-1 viruses arose from vaccine strains [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis of Infectious Bronchitis Virus S1 Gene Reveals Novel Amino Acid Changes in the GI-16 Lineage in Peru

et al. 2023

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Infectious bronchitis is a highly contagious viral disease that represents an economic threat for poultry despite the wide use of vaccination. To characterize the virus circulating in Peru, we analyzed 200 samples, including nasopharyngeal swabs and multiple tissues collected from animals suspected of being infected with infectious bronchitis virus (IBV) between January and August in 2015. All animals had at least one positive sample for IBV by RT-PCR. Out of these positive samples, eighteen (18) were selected for viral isolation and a partial S1 sequencing. Phylogenetic analysis showed that sixteen isolates clustered with members of GI-16 lineage, also known as Q1, with nucleotide homology ranging from 93% to 98%. The two remaining isolates grouped with members of the GI-1 lineage. Our study reveals circulation of GI-16 lineage during this period in poultry systems in Peru, along with GI-1 lineage (vaccine-derived). Moreover, those IBV GI-16 isolates showed unique nucleotide and amino acid changes compared to their closest relatives. Altogether, these findings reveal the circulation of GI-16 lineage while describing changes at key regions of the S protein that might be of relevance for vaccine evasion. These results highlight the importance of genetic surveillance for improving vaccination strategies against infectious bronchitis.

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