Complete Genome Sequence of an Avian Leukosis Virus Isolate Associated with Hemangioma and Myeloid Leukosis in Egg-Type and Meat-Type Chickens

Ji, Jun; Li, Hongxin; Zhang, Huanmin; Xie, Qingmei; Chang, Shuang; Shang, Huiqin; Ma, Jingyun; Bi, Yanlan

doi:10.1128/jvi.01894-12

Cited by 16 publications

(6 citation statements)

References 8 publications

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“…Up to now, there are seven subgroups of ALV in chickens: ALV-A, -B, -C, -D, -E, -J and -K [19,20]. ALV-J was first detected in meat-type chickens in 1987 as a new subgroup [21] and has spread to many countries such as America [22], UK [23], China [24] and so on. Clinical infection is associated with immune tolerance, high mortality, delayed growth, inducing different kinds of tumors [25,26].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Identification of aberrantly expressed circRNAs in subgroup J avian leucosis virus induced tumor livers by RNA sequencing

Zhang¹,

Yan²,

Lei³

et al. 2018

Oncotarget

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ALV-J (subgroup J avian leucosis virus) is a kind of oncogenic exogenousretrovirus and diseases associated with ALV-J have caused severe reproduction problems in the poultry industry worldwide. However, the pathogenesis of ALV-Jinduced tumor formation is still unclear. In recent years, circRNAs are validated to be related to cancer, which prompts us to explore whether aberrant expression of circRNAs exists in ALV-J-infected tumor samples. In this study, a total of 2822 differentially expressed circRNAs were detected by RNA sequencing in the tumor livers of ALV-J-susceptible chickens (n = 3) and the normal liver samples of ALV-J-resistant chickens (n = 3), among which 2808 circRNAs in the tumor liver samples were detected as unregulated compared to those in the normal liver samples. As circRNAs are considered as miRNA sponge, we predicted top 5 miRNA targets for 24 selected upregulated circRNAs in the ALV-J-induced tumor livers. CircRNA-miRNA-mRNA regulatory axes were also constructed to provide clear interaction relationship among them. Furthermore, Gene Ontology and KEGG pathway analyses were performed for miRNA target genes, the result of which implied that metabolism plays a key role in circRNAs alterations in ALV-J-induced tumor livers. In summary, we identified that circRNAs are involved in ALV-J-induced tumor formation in chickens. However, the pathogenicity mechanism still needs to be further explored.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Identification of aberrantly expressed circRNAs in subgroup J avian leucosis virus induced tumor livers by RNA sequencing

Zhang¹,

Yan²,

Lei³

et al. 2018

Oncotarget

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“…The subgroup J Avian Leukosis virus (ALV-J) can form tumors on chickens and can thus lead to their death; it also can cause non-tumor diseases, namely the secondary infection caused by immunosuppression [ 1 ]. The symptoms are emaciation, anemia, tolerance viremia, and immunosuppression, all of which are able to seriously affect poultry production [ 2 , 3 ]. ALV-J has affected the poultry industry worldwide, with the exception of New Zealand.…”

Section: Introductionmentioning

confidence: 99%

Role of gga-miR-221 and gga-miR-222 during Tumour Formation in Chickens Infected by Subgroup J Avian Leukosis Virus

Dai

Yan

et al. 2015

Viruses

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Subgroup J avian leukosis virus (ALV-J) causes a neoplastic disease in infected chickens. Differential expression patterns of microRNAs (miRNAs) are closely related to the formation and growth of tumors. (1) Background: This study was undertaken to understand how miRNAs might be related to tumor growth during ALV-J infection. We chose to characterize the effects of miR-221 and miR-222 on cell proliferation, migration, and apoptosis based on previous microarray data. (2) Methods: In vivo, the expression levels of miR-221 and miR-222 were significantly increased in the liver of ALV-J infected chickens (p < 0.01). Over-expression of gga-miR-221 and gga-miR-222 promoted the proliferation, migration, and growth of DF-1 cells, and decreased the expression of BCL-2 modifying factor (BMF) making cells more resistant to apoptosis. (3) Results: Our results suggest that gga-miR-221 and gga-miR-222 may be tumour formation relevant gene in chicken that promote proliferation, migration, and growth of cancer cells, and inhibit apoptosis. BMF expression was significantly reduced in vivo 70 days after ALV-J infection. They may also play a pivotal role in tumorigenesis during ALV-J infection.

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“…The duck in this report tested positive for ALV, which has been associated with many types of neoplasms, including hemangiomas . This duck later developed another foot lesion, which was diagnosed histologically as a hemangioma.…”

Section: Discussionmentioning

confidence: 60%

What is your diagnosis? Mass on the foot of a duck

Piccione

Bryan

Hoppes

et al. 2017

Veterinary Clinical Pathol

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An adult White Peking duck (Anas platyrhynchos domestica) was presented to the Texas A&M Veterinary Medical Teaching Hospital for mild trauma after being attacked by several canine puppies. The duck lived on a small, privately owned farm which also housed chickens and small ruminants. On physical examination, the duck had several superficial wounds on the dorsum, which were associated with the recent trauma. Incidentally, a one cm diameter, round, subcutaneous mass was palpated in the webbing of the right foot between the 2 nd and 3 rd phalanges. The mass appeared to be extending into the underlying ventral dermis. A fine-needle aspirate of the mass was collected (Figure 1). Plasma chemistry revealed a moderately elevated CK activity (4744 U/L; RI 165-378 U/L), which was attributed to the recent trauma. A CBC revealed a mild heterophilia (13,944/lL; RI 7420-12,720/lL). Figure 1. Fine-needle aspirate of a foot mass in a Peking duck. Modified Wright's stain, 960 objective. A B

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Complete Genome Sequence of an Avian Leukosis Virus Isolate Associated with Hemangioma and Myeloid Leukosis in Egg-Type and Meat-Type Chickens

Cited by 16 publications

References 8 publications

WITHDRAWN: Identification of aberrantly expressed circRNAs in subgroup J avian leucosis virus induced tumor livers by RNA sequencing

WITHDRAWN: Identification of aberrantly expressed circRNAs in subgroup J avian leucosis virus induced tumor livers by RNA sequencing

Role of gga-miR-221 and gga-miR-222 during Tumour Formation in Chickens Infected by Subgroup J Avian Leukosis Virus

What is your diagnosis? Mass on the foot of a duck

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