Complete Genome Sequence of a Newcastle Disease Virus Strain Belonging to a Recently Identified Genotype

Briand, François-Xavier; Henry, Aurélie; Brown, Paul A.; Massin, Pascale; Jestin, Véronique

doi:10.1128/genomea.00100-12

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…Full genome sequences of APMV-1 strains of the differently identified genotypes circulating across the globe have been published [17,20,34,52,59,107]. In West Africa, however, only four complete genome sequences of the virus circulating in this sub-region are available in the sequence repositories (GenBank, DDBJ, and EMBL) as of 30th May, 2016.…”

Section: Newcastle Disease Virusmentioning

confidence: 99%

Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

2016

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Over the years, Newcastle disease (ND) has defied all available control measures. The disease has remained at the forefront of infectious diseases afflicting poultry production after avian influenza. Despite the continuous global use of million doses of ND vaccine annually, the causative pathogen, avian paramyxovirus type 1 also known as Newcastle disease virus (NDV) has continued to evolve causing, even more, a threat not only to the unvaccinated but the vaccinated flocks inclusive. The disease has been well studied in the developed countries where the virus is found in circulation. However, limited information exists on the epizootiology and circulating genotypes of the virus in developing countries where the majority of the flocks are raised on the extensive management system. Identification of virulent NDV in apparently healthy free-range ducks in this system calls for concern and pragmatic approach to investigate factor(s) that favour the virus inhabiting the ducks without clinical manifestation of the disease. Recently, novel genotypes (XIV, XVII, and XVIII) with peculiarity to West and Central African countries have been discovered and due to lack or poor surveillance system possibility of hitherto unreported genotypes are likely. This review elucidates and discusses available literature on the diversity of the circulating NDV genotypes across the West Africa countries and the epizootiology (molecular) of the disease in Nigeria with the view of identifying gaps in knowledge that can assist in the development of effective vaccines and control strategies to combat the peril of the disease.

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Section: Newcastle Disease Virusmentioning

confidence: 99%

Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

2016

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“…Avian paramyxovirus type 1 (NDV) Teal/France/100011/2010, recently identified as a new genotype (Briand et al, 2013), was propagated via the allantoic sac into 9-day SPF chicken embryos (source ANSES Ploufragan) according to the OIE Manual of Standards for Diagnostic Tests and Vaccines (OIE, 2012). Eggs were checked daily.…”

Section: Virusesmentioning

confidence: 99%

“…Determination of full length genomic sequence is now a fundamental aspect of modern virology and plays an important role in the characterization of new and/or emerging virus strains (Briand et al, 2013;de Graaf et al, 2008;Miller et al, 2009), in setting up reverse genetic systems that are critical to assess specific genetic mutations (Brown et al, 2011;Conzelmann and Schnell, 1994;Ling et al, 2008;Naylor et al, 2007;Peeters et al, 1999) and in the study of the virus evolution (Lwamba et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

An alternative method to determine the 5′ extremities of non-segmented, negative sense RNA viral genomes using positive replication intermediate 3′ tailing: Application to two members of the Paramyxoviridae family

Brown

Briand

Guionie

et al. 2013

Journal of Virological Methods

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“…The APMVs have been divided into nine serotypes (APMV 1 to 9) based on hemagglutination inhibition (HI) and neuraminidase inhibition (NI) assays [1]. More recently, viruses representing potential APMV serotypes 10 and 11 were isolated from Rockhopper Penguins [2] and common teal [3], respectively. APMV-1, which includes all strains of Newcastle disease virus (NDV), has been extensively characterized because virulent NDV strains cause severe disease in chickens.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Replication, Pathogenicity, and Immunogenicity of Avian Paramyxovirus (APMV) Serotypes 2, 3, 4, 5, 7, and 9 in Rhesus Macaques

et al. 2013

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Avian paramyxoviruses (APMV) serotypes 1–9 are frequently isolated from domestic and wild birds worldwide. APMV-1 (also called Newcastle disease virus, NDV) is attenuated in non-human primates and is being developed as a candidate human vaccine vector. The vector potential of the other serotypes was unknown. In the present study, we evaluated nine different biologically- or recombinantly-derived APMV strains for the ability to replicate and cause disease in rhesus macaque model. Five of the viruses were: biologically-derived wild type (wt) APMV-2, -3, -5, -7 and -9. Another virus was a recombinant (r) version of wt APMV-4. The remaining three viruses were versions of wt rAPMV-2, -4 and -7 in which the F cleavage site had been modified to be multi-basic. Rhesus macaques were inoculated intranasally and intratracheally and monitored for clinical disease, virus shedding from the upper and lower respiratory tract, and seroconversion. Virus shedding was not detected for wt APMV-5. Very limited shedding was detected for wt rAPMV-4 and modified rAPMV-4, and only in a subset of animals. Shedding by the other viruses was detected in every infected animal, and usually from both the upper and lower respiratory tract. In particular, shedding over a number of days in every animal was observed for modified rAPMV-2, wt APMV-7, and modified rAPMV-7. Modification of the F protein cleavage site appeared to increase shedding by wt rAPMV-2 and marginally by wt rAPMV-4. All APMVs except wt APMV-5 induced a virus-specific serum antibody response in all infected animals. None of the animals exhibited any clinical disease signs. These results indicate that APMVs 2, 3, 4, 7, and 9 are competent to infect non-human primates, but are moderately-to-highly restricted, depending on the serotype. This suggests that they are not likely to significantly infect primates in nature, and represent promising attenuated candidates for vector development.

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Complete Genome Sequence of a Newcastle Disease Virus Strain Belonging to a Recently Identified Genotype

Abstract: We report the first complete genome sequence of a strain that presents some pathogenicity and that belongs to a recently characterized genotype of avian paramyxovirus type 1 (APMV-1). This virus, isolated from the common teal, presents the most divergent genome within class I of APMV-1.

Cited by 8 publications

References 8 publications

Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

An alternative method to determine the 5′ extremities of non-segmented, negative sense RNA viral genomes using positive replication intermediate 3′ tailing: Application to two members of the Paramyxoviridae family

Evaluation of the Replication, Pathogenicity, and Immunogenicity of Avian Paramyxovirus (APMV) Serotypes 2, 3, 4, 5, 7, and 9 in Rhesus Macaques

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