Complete Freund’s adjuvant as a confounding factor in multiple sclerosis research
Milica Lazarević,
Suzana Stanisavljević,
Neda Nikolovski
et al.
Abstract:Complete Freund’s adjuvant (CFA) is used as a standard adjuvant for the induction of experimental autoimmune encephalomyelitis (EAE), the most commonly used animal model in multiple sclerosis studies. Still, CFA induces glial activation and neuroinflammation on its own and provokes pain. In addition, as CFA contains Mycobacteria, an immune response against bacterial antigens is induced in parallel to the response against central nervous system antigens. Thus, CFA can be considered as a confounding factor in mu… Show more
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