Complete fracture and restenosis of sirolimus-eluting stent in ostial saphenous vein graft

Ohgo, Takeshi; Otsuka, Yoritaka; Furuno, Takashi

doi:10.1016/j.ijcard.2007.04.175

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…These are macrolide antibiotics, which are frequently used as immunosuppressants. Since Salas-Prato et al revealed that SR inhibits platelet-derived growth factor- and basic fibroblast growth factor-induced proliferation of human Tenon’s fibroblasts in vitro , the antifibrotic effect of SR was demonstrated in several studies [18–20]. Therefore, SR has also been frequently used as a coating drug in coronary stents to prevent restenosis of coronary arteries.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis

et al. 2019

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Purpose To find safer and more effective drugs than mitomycin C to prevent conjunctival fibrosis in a rabbit model. Methods Twenty-four rabbits were involved and randomly divided into four groups. Limbus-based peritomy was performed at the superior cornea, and normal saline (NS group), mitomycin C (MMC group), SR (SR group), or TC (TC group)-coated silicone plate was inserted at the sub-Tenon’s space in each group. Conjunctival congestion was evaluated at 1 and 4 weeks postoperatively. At 4 weeks, the numbers of inflammatory cells, fibroblasts, myofibroblasts, blood vessels, and goblet cells were counted in the conjunctiva and Tenon’s capsule around the silicone plate. Results At 4 weeks, conjunctival congestion was significantly less than that observed at 1 week in the SR and TC groups ( p < 0.05), whereas the number of myofibroblasts was significantly lower in the MMC and TC groups ( p < 0.05). The conjunctiva was significantly less congested in the TC group versus the other groups at 1 week and 4 weeks ( p < 0.05). The TC group had the lowest number of inflammatory cells and MMC group had the lowest number of goblet cells among all groups ( p < 0.05). Conclusions The TC-coated silicone plate was more effective in inhibiting inflammation and fibrosis versus the MMC-coated silicone plate and was associated with fewer adverse effects in the rabbit model.

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis

et al. 2019

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“…The deployment of stents can lead to a more enhanced inflammatory and thrombotic reaction [23]. There have been some isolated case reports showing that one possible mechanism of restenosis of DES in SVGs is related to the excessive curvature of DES during cardiac contractions leading to stent fracture and failure of local drug delivery [24,25]. Additionally studies of BMS vs. DES indicate that late complication rates of DES may be excessive as a result of the potential late ''catch up'' phenomenon [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Outcomes following PCI in patients with previous CABG

Bundhoo

Kalla

Anantharaman

et al. 2011

Cathet Cardio Intervent

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“…As of July, 2008, 174 articles regarding stent fracture were found using the above search criteria. These were narrowed down to 11 studies [10–20] (Table I) and 23 case reports [21–43] (Table II). The studies were heterogeneous in design and included four retrospective studies, six prospective studies, and one randomized multicenter study comparing Cypher and Taxus stents.…”

Section: Methodsmentioning

confidence: 99%

Drug‐eluting stent fracture: Incidence, contributing factors, and clinical implications

Canan

Lee

2009

Cathet Cardio Intervent

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Stent fracture has been observed in noncoronary vessels, especially in the superficial femoral and popliteal arteries and with bare metal stents in saphenous vein grafts of coronary arteries. Since the introduction of drug-eluting stents, stent fractures have also been reported in small studies and case reports. We reviewed these publications to assess what is known regarding the incidence, contributing factors, and clinical implications of drug-eluting stent fracture in coronary arteries. The reported rate of drug-eluting stent fracture in coronary arteries ranges from 1 to 8%, although much of the available literature is derived from single-center studies that are heterogeneous in their study methods. A higher risk of stent fracture may be associated with the right coronary artery location, excessive tortuosity or angulation of the vessel, overlapping stents, and longer stents. The closed-cell design of the Cypher stent has been associated with increased rigidity that may increase the risk of stent fracture, although these studies did not assess the overall outcomes between the Cypher and Taxus stents in a head-to-head comparison. Stent fracture has been shown by most studies to be associated with a statistically increased incidence of focal in-stent restenosis, and some have shown an increased risk of target lesion revascularization. Other complications observed with stent fracture include stent thrombosis, coronary aneurysms, myocardial infarction, and sudden death.

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Complete fracture and restenosis of sirolimus-eluting stent in ostial saphenous vein graft

Cited by 6 publications

References 2 publications

Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis

Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis

Outcomes following PCI in patients with previous CABG

Drug‐eluting stent fracture: Incidence, contributing factors, and clinical implications

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