Complete Femoral Nerve Transection with Sural Nerve Cable Graft in a 21-Month-Old Child

Pillutla, Pranati; Nix, Evan; Elberson, Benjamin W.; Nagy, László

doi:10.4103/jnrp.jnrp_235_18

Cited by 3 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When used as a graft, it provides a scaffold with hundreds to thousands of basal lamina tubes to support Schwann cell and axon migration [9]. Although being a pure sensory nerve, it was also shown to be a good cable-grafting donor nerve in motor nerve recovery in a child [12], although in most cases it is used in adults and older patients, which raises the issue of the possible influence of aging on the outcome of axon recovery.…”

Section: Morphometric Analysis Of the Human Endoneurial Extracellularmentioning

confidence: 99%

Morphometric analysis of the human endoneurial extracellular matrix components during aging

Kundalic

Ugrenovic

Jovanović

et al. 2021

ARCH BIOL SCI BELGRA

View full text Add to dashboard Cite

The aim of this study was to analyze the expression of extracellular matrix (ECM) proteins in human endoneurium during aging. We harvested 15 cadaveric sural nerves, distributed in 3 age groups (I: 25-44, II: 45-64, III: 65-86 years old). Histological sections were stained immunohistochemically for the presence of collagen type I, type IV and laminin, and the ImageJ processing program was used in morphometrical analysis to determine the percentages of these endoneurial proteins. In two younger groups, the endoneurial matrix of the sural nerve was composed from about equal proportions of these proteins, which may be considered a favorable microenvironment for the regeneration of nerve fibers. Linear regression analysis showed a significant increase in endoneurial collagen type IV with age, while collagen type I and laminin significantly decreased during the aging process. In cases older than 65 years, remodeling of the endoneurial matrix was observed to be significantly higher for the presence of collagen type IV, and lower for the expression of collagen type I and laminin. This age-related imbalance of ECM proteins could represent a disadvantageous microenvironment for nerve fiber regeneration in older adults. Our findings contribute to the development of therapeutic approaches for peripheral nerve regeneration.

show abstract

Section: Morphometric Analysis Of the Human Endoneurial Extracellularmentioning

confidence: 99%

Morphometric analysis of the human endoneurial extracellular matrix components during aging

Kundalic

Ugrenovic

Jovanović

et al. 2021

ARCH BIOL SCI BELGRA

View full text Add to dashboard Cite

show abstract

Different Surgical Reconstructions for Femoral Nerve Injury

Cao

Li²,

Zhang

et al. 2020

Ann Plast Surg

View full text Add to dashboard Cite

Background Femoral nerve palsy can cause loss in quadriceps function and knee extension disability, which may lead to severe lower extremity impairment. The obturator nerve trunk transfer in the pelvic, the obturator nerve mortal branches transfer out of the pelvic, along with nerve graft, was introduced years ago to restore femoral nerve function. However, the outcomes of these procedures have never been compared. The aims of this study were to give our experiences in surgical reconstruction for femoral nerve injury and to compare the outcomes of different approaches. Methods Nine patients with complete femoral nerve injury have been enrolled in this study between March 2012 and July 2016. All patients were followed up for at least 2 years after surgical intervention for sural nerve graft (n = 3), obturator trunk transfer in the pelvic (n = 2), or obturator nerve mortal branches transfer out of the pelvic (n = 4). Results All patients gained satisfactory quadriceps Medical Research Council grade (M3–M4+) after more than 2 years of follow-up. The sural nerve graft led to the earliest recovery on average, followed by obturator nerve mortal branches transfer in the thigh level and then obturator nerve trunk transfer in the pelvic. The functional outcomes, demonstrated by Lower Extremity Functional Scale and Femoral Nerve Motor Function Scale scores, also showed that the sural nerve graft was the best on average, followed by obturator nerve trunk transfer in the pelvic and then obturator nerve mortal branches transfer in the thigh level. Conclusions Our results indicate that all these 3 procedures are safe and reliable ways to reconstruct femoral nerve function and can be applied to patients with different kinds of injuries. The sural nerve graft should be considered in the first place and the obturator nerve transfer at different level (trunk transfer in the pelvic or mortal branches transfer out of the pelvic) can be performed as the alternative.

show abstract

Femoral nerve repair with autografts for proximal retroperitoneal damage (case report and literature review)

Govenko,

Gusev,

Komantsev

et al. 2024

Vopr. neirokhir.

View full text Add to dashboard Cite

Complete Femoral Nerve Transection with Sural Nerve Cable Graft in a 21-Month-Old Child

Cited by 3 publications

References 10 publications

Morphometric analysis of the human endoneurial extracellular matrix components during aging

Morphometric analysis of the human endoneurial extracellular matrix components during aging

Different Surgical Reconstructions for Femoral Nerve Injury

Femoral nerve repair with autografts for proximal retroperitoneal damage (case report and literature review)

Contact Info

Product

Resources

About