Complete design of a simulated moving bed

Charton, Frédéric; Nicoud, Roger‐Marc

doi:10.1016/0021-9673(94)01026-b

Cited by 193 publications

(68 citation statements)

References 16 publications

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“…Recently, there has been a strong trend toward using recycling techniques (44) and SMB chromatography (45)(46)(47)(48)(49). To understand SMB, first imagine the batch elution separation of components A and B (Figure 5a), with the A molecules moving ahead of the slower B molecules.…”

Section: S Si Im Mu Ul La At Te Ed D M Mo Ov Vi In Ng G B Be Ed Dmentioning

confidence: 99%

Peer Reviewed: Nonlinear Effects in LC and Chiral LC

Fornstedt¹,

Guiochon²

2001

Anal. Chem.

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See https://pubs.acs.org/sharingguidelines for options on how to legitimately share published articles. N O V E M B E R 1 , 2 0 0 1 / A N A LY T I C A L C H E M I S T R Y6 0 9 A o achieve high resolution and accurate peak integration, analytical chromatographers choose experimental conditions under which nonlinear effects are minimized. Careful use of these same effects allows them to design profitable separations.Nonlinear effects are ubiquitous. There are almost no experimental conditions under which they do not exist, although under many they are negligible. The key to understanding nonlinear effects lies in the equilibrium isotherms, the relationship between the solute concentrations at equilibrium in the two phases of the system. In most separations, particularly in chiral ones, the determination of these isotherms also allows more accurate investigation of the retention mechanism. We will show how band profiles can be modeled, why the model results are useful, and how systematic isotherm mea surements allow a deeper understanding of certain retention mechanisms.W Wh ha at t i is s n no on nl li in ne ea ar r c ch hr ro om ma at to og gr ra ap ph hy y? ?The goal of preparative chromatography is the rapid preparation of a significant amount of one component in a mixture to a sufficient degree of purity (1). Thus, large amounts of high-concentration samples are injected. Because of the finite surface area of the stationary phase in the column, the relative amount of a component adsorbed at equilibrium usually decreases as concentration increases, affecting retention. This phenomenon characterizes nonlinear chromatography.Peaks tail strongly in preparative chromatography, in contrast to the symmetrical peaks in analytical (i.e., linear) chromatography (2). Most often, nonlinear tailing peaks have sharp fronts and long, diffuse rear boundaries. The retention time of the high-concentration front decreases with increasing sample size, while the end of the peak tail has a con-

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Section: S Si Im Mu Ul La At Te Ed D M Mo Ov Vi In Ng G B Be Ed Dmentioning

confidence: 99%

Peer Reviewed: Nonlinear Effects in LC and Chiral LC

Fornstedt¹,

Guiochon²

2001

Anal. Chem.

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“…26 A number of authors have since proposed methods for optimizing SMB performance. [22][23][24][25][27][28][29][30] In our process design work, we have introduced the use of profile advancement factors obtained from pulse tests and emphasized generation of key miniplant data to quickly develop an accurate simulation. To illustrate the methodology, we chose the protein separation studied by Houwing et al 20 as a model system.…”

Section: Introductionmentioning

confidence: 99%

SMB chromatography design using profile advancement factors, miniplant data, and rate‐based process simulation

et al. 2009

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This article describes a systematic miniplant-based approach to rapid development of simulated moving bed (SMB) chromatography applications. The methodology involves analysis of single-column pulse tests to screen adsorbents and operating conditions and to determine initial values of profile advancement factors used to specify flow rates for an initial SMB miniplant experiment. A lumped-parameter linear driving force rate-based model is developed by fitting process data from a single miniplant run. The data are fit in a two-step procedure involving initial determination of effective adsorption isotherm constants as best-fit parameters with subsequent adjustment of calculated mass transfer coefficients to refine the data fit. The resulting simulation is used to guide further miniplant work and minimize experimental effort. The methodology is illustrated with miniplant data for a binary protein separation showing excellent agreement between model results and process data generated over a wide range of operating conditions.

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“…However, higher productivity and a lower desorbent requirement per unit mass of product motivate this pursuit. A reliable design of the nonlin-Ž ear separation based on detailed Charton and Nicoud, 1995; . Pais et al, 1997;Wu et al, 1998;Migliorini et al, 1999a or Ž .…”

Section: Introductionmentioning

confidence: 99%

Shortcut experimental method for designing chiral SMB separations

et al. 2002

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The simulated moving-bed (SMB) chromatographic separation of the Troger's base enantiomers with ethanol as eluent on microcrystalline triacetate cellulose was studied. An experimental technique to design nonlinear SMB separations with few column experiments is presented. This shortcut technique allows the rigorous solution of the Equilibrium Theory model to be approximated without knowing the adsorption equilibria, and therefore can be useful in developing new separations. The predictions of the shortcut method are compared with the experimental results of the SMB separation. The effect of the feed concentration and of the nonideal contributions, such as mass-transfer resistance and extracolumn band broadening are elucidated

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Complete design of a simulated moving bed

Cited by 193 publications

References 16 publications

Peer Reviewed: Nonlinear Effects in LC and Chiral LC

Peer Reviewed: Nonlinear Effects in LC and Chiral LC

SMB chromatography design using profile advancement factors, miniplant data, and rate‐based process simulation

Shortcut experimental method for designing chiral SMB separations

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