Complete Coding Sequences of Three Members of the Kokobera Group of Flaviviruses

Warrilow, David; Hall‐Mendelin, Sonja; Hobson‐Peters, Jody; Prow, Natalie A.; Allcock, Richard J. N.; Hall, Roy A.

doi:10.1128/genomea.00890-14

Cited by 7 publications

(5 citation statements)

References 16 publications

(21 reference statements)

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“…RRV TT genome sequencing was performed as described previously [ 66 ]. Briefly, sequence-independent amplification was performed on viral RNA extracted from the isolate grown in C6/36 cells.…”

Section: Methodsmentioning

confidence: 99%

Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models

et al. 2020

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Chikungunya virus (CHIKV), Ross River virus (RRV), o’nyong nyong virus (ONNV), Mayaro virus (MAYV) and Getah virus (GETV) represent arthritogenic alphaviruses belonging to the Semliki Forest virus antigenic complex. Antibodies raised against one of these viruses can cross-react with other serogroup members, suggesting that, for instance, a CHIKV vaccine (deemed commercially viable) might provide cross-protection against antigenically related alphaviruses. Herein we use human alphavirus isolates (including a new human RRV isolate) and wild-type mice to explore whether infection with one virus leads to cross-protection against viremia after challenge with other members of the antigenic complex. Persistently infected Rag1-/- mice were also used to assess the cross-protective capacity of convalescent CHIKV serum. We also assessed the ability of a recombinant poxvirus-based CHIKV vaccine and a commercially available formalin-fixed, whole-virus GETV vaccine to induce cross-protective responses. Although cross-protection and/or cross-reactivity were clearly evident, they were not universal and were often suboptimal. Even for the more closely related viruses (e.g., CHIKV and ONNV, or RRV and GETV), vaccine-mediated neutralization and/or protection against the intended homologous target was significantly more effective than cross-neutralization and/or cross-protection against the heterologous virus. Effective vaccine-mediated cross-protection would thus likely require a higher dose and/or more vaccinations, which is likely to be unattractive to regulators and vaccine manufacturers.

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Section: Methodsmentioning

confidence: 99%

Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models

et al. 2020

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“…We sequenced 9 WNV KUN genomes ( Technical Appendix Table 1) by using random primer sequencing on extracts of C6/36 cell cultures ( 17 ). Viral RNA was extracted by using a MagMAX-96 Viral RNA Isolation Kit (Ambion, Waltham, MA, USA) according to the manufacturer’s instructions.…”

Section: Methodsmentioning

confidence: 99%

Virulence and Evolution of West Nile Virus, Australia, 1960–2012

Prow¹,

Edmonds²,

Setoh³

et al. 2016

Emerg. Infect. Dis.

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“…At this stage, all five members of the KOKV group will need further characterization and definition. Recently, the complete coding sequences of STRV, BAIV and Torres virus have become publicly available and is first step towards understanding the virus’ virulence [ 153 ].…”

Section: Kokobera and Related Virusesmentioning

confidence: 99%

Mosquito-Borne Viruses and Non-Human Vertebrates in Australia: A Review

Ong,

Skinner,

Johnson

et al. 2021

Viruses

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Mosquito-borne viruses are well recognized as a global public health burden amongst humans, but the effects on non-human vertebrates is rarely reported. Australia, houses a number of endemic mosquito-borne viruses, such as Ross River virus, Barmah Forest virus, and Murray Valley encephalitis virus. In this review, we synthesize the current state of mosquito-borne viruses impacting non-human vertebrates in Australia, including diseases that could be introduced due to local mosquito distribution. Given the unique island biogeography of Australia and the endemism of vertebrate species (including macropods and monotremes), Australia is highly susceptible to foreign mosquito species becoming established, and mosquito-borne viruses becoming endemic alongside novel reservoirs. For each virus, we summarize the known geographic distribution, mosquito vectors, vertebrate hosts, clinical signs and treatments, and highlight the importance of including non-human vertebrates in the assessment of future disease outbreaks. The mosquito-borne viruses discussed can impact wildlife, livestock, and companion animals, causing significant changes to Australian ecology and economy. The complex nature of mosquito-borne disease, and challenges in assessing the impacts to non-human vertebrate species, makes this an important topic to periodically review.

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Complete Coding Sequences of Three Members of the Kokobera Group of Flaviviruses

Cited by 7 publications

References 16 publications

Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models

Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models

Virulence and Evolution of West Nile Virus, Australia, 1960–2012

Mosquito-Borne Viruses and Non-Human Vertebrates in Australia: A Review

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