Complete Blood Count Parameters, C-Reactive Protein and the Severity of Coronavirus Disease

Igala, Marielle; Bivigou, Elsa Ayo; Kombila, U.D.; Ngomas, Jean F; Mougougou, Adrien; Makao, Arsene Ifoudji; Manomba, Charleine; Mistoul, Irene A; Ngoua, Stephanie Ntsame; Ebang, Gabrielle Atsame; Mbourou, Anita Akiko; Metogho,; Mpemba, Liliane F; Mfoumou, Annick F; Ada, Fifi C Loembe; Rerambiah, Léonard Kouegnigan; Boguikouma, Jean B; Akotet, Marielle Karine Bouyou

doi:10.7754/clin.lab.2021.201208

Cited by 2 publications

(4 citation statements)

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“…In terms of clinical characteristics, the majority of patients (56%) presented a mild/moderate form of the disease (Table 1) consistent with previous studies in Cameroon and Gabon (Mekolo et al, 2021;Igala et al, 2021).…”

Section: Discussionsupporting

confidence: 88%

“…Indeed, we found that CRP and LDH concentrations increased gradually with disease severity (Table 2). This association was not observed in Ghana (Afriyie-Mensah et al, 2021) but other studies from different geographic locations found the same results (Kantri et al, 2021;Igala et al, 2021;Malik et al, 2021). High levels of CRP and LDH are key markers of COVID-19 progression and are associated with mortality risk factors due to disease severity (Chen et al, 2021;Gao et al, 2021;Ali et al, 2022).…”

Section: Discussionmentioning

confidence: 74%

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Biochemical and hematological factors associated with COVID-19 severity among Gabonese patients: A retrospective cohort study

N’Dilimabaka

Mounguegui²,

Lekana-Douki

et al. 2022

Front. Cell. Infect. Microbiol.

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The COVID-19 disease presents a large range of clinical manifestations and includes asymptomatic, mild, and severe cases. The level of severity is related to parameters associated with immunity, genetics, and biochemistry. Africa shows one of the lowest COVID-19 fatality rates but very few data on the biochemical markers of COVID-19 in patients and the factors associated with disease severity are available for the continent. In Gabon, the COVID-19 fatality rate is only 0.63% but almost no data on biomarkers in COVID-19 patients have been published. Both the number of COVID-19 cases and the mortality rate reported in Africa in general, and in Gabon in particular, are lower than in non-African countries. As such, understanding the factors associated with disease severity in Gabonese patients is a crucial step to better understand the disease in the African context and prepare for future COVID-19 waves and other epidemics of emerging diseases. Here, we compared biochemical and hematological markers among 753 Gabonese COVID-19 patients with asymptomatic (184/753), mild/moderate (420/753), and severe/critical (149/753) forms of the disease using an Analysis of Variance (ANOVA) or a Kruskal-Wallis (KW) test. We modeled these parameters together with comorbidities, age, and sex to predict factors associated with disease severity by using a "binomial generalized linear model" utilizing the "package" stats of R software version 4.0.2. Our results showed that almost all the biochemical and hematological parameters (except creatinine, phosphorus, D-dimers, platelets, and monocytes) varied according to disease severity. However, age and the dysfunction of organs like the kidney, liver, and lung together with the decrease of electrolytes (chloride, potassium, and sodium) are the best predictors of disease severity in Gabonese patients.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 74%

Biochemical and hematological factors associated with COVID-19 severity among Gabonese patients: A retrospective cohort study

N’Dilimabaka

Mounguegui²,

Lekana-Douki

et al. 2022

Front. Cell. Infect. Microbiol.

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“…The socio-demographic characteristics of the participants in this study are similar to other reports on long COVID, including the median age of 46 years and the male predominance [27,30,31]. The latter is due to the high prevalence of men hospitalized for severe COVID in Gabon [32,33]. No relationship was established between the gender and the frequency of long COVID.…”

Section: Factors Associated With Long Covidsupporting

confidence: 83%

“…Our population sample size, the prevalence of young adults (the majority of whom did not have comorbidities), and the fact that all patients had severe COVID, may explain these results different from those reported by many authors [13,19,31,36,37]. Indeed, associations between persistent symptoms in patients and pre-existing hypertension, chronic lung disease, obesity, or asthma were recorded [28,33,34]. Surprisingly, diabetics were less likely to have long COVID compared to non-diabetics.…”

Section: Factors Associated With Long Covidmentioning

confidence: 61%

Post-COVID-19 Clinical Symptom Frequency and Associated Factors in a Cohort of Patients Discharged from the ICU and Monitored for 12 Months, in Libreville, Gabon

Charleine,

Bridy,

Moukady

et al. 2023

IJTDH

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Aims: This study determined the prevalence and evolution of long COVID symptoms in patients hospitalized for severe COVID-19 at the CHUL intensive care unit in Libreville, Gabon. Study Design: Prospective, longitudinal, study. Place and Duration of Study: Infectiology Unit, Centre Hospitalier Universitaire de Libreville Hospitalier Universitaire de LibrevH (CHUL), between January 2021 and January 2022. Methodology: We included 144 patients (84 men, 60 women; median age 46.4 [16-88] years) hospitalized in the intense care unit for a RT-PCR- confirmed COVID-19 and who have accepted a one-year follow-up. All patients were consulted quarterly for 12 months. During the follow-up, existence, appearance and types of symptoms were sought at 3, 6 and 12-months post-hospitalization. Results: The prevalence of long COVID-19 was 52.1% (n=75/144). Fatigue (21.3%), cough (20.8%), sleep disorders (16.0%) and anxiety (11.1%) predominated at month-3. The main symptoms reported 6-months after the onset of infection were dyspnea (9.7%; n=14), anxiety (7.6%; n=11), fatigue (6.2%; n=9) and cough (3.5%; n=5). One year after, the persistent symptoms were anxiety (6.5%; n=9), dyspnea (1.4%; n=2). Most participants had only one symptom: 60% at month-3, 79.5% at month-6 and 77.8% at 12-months (p=0.04). Conclusion: The long COVID is frequent among patients hospitalized for severe form of SARS-COV-2 infection. It is imperative to continue generating information for appropriate prevention and monitoring measures to be adopted in Gabon.

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Complete Blood Count Parameters, C-Reactive Protein and the Severity of Coronavirus Disease

Cited by 2 publications

References 0 publications

Biochemical and hematological factors associated with COVID-19 severity among Gabonese patients: A retrospective cohort study

Biochemical and hematological factors associated with COVID-19 severity among Gabonese patients: A retrospective cohort study

Post-COVID-19 Clinical Symptom Frequency and Associated Factors in a Cohort of Patients Discharged from the ICU and Monitored for 12 Months, in Libreville, Gabon

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