Complete blood count-derived inflammatory markers in adolescents with primary arterial hypertension: a preliminary report

Abstract

Aim of the studyThe aim of our study was to evaluate selected inflammatory markers in children with untreated primary hypertension and to establish the relation between inflammatory markers and 24-hour ambulatory blood pressure monitoring (ABPM) and clinical and biochemical parameters.Material and methodsIn 54 children (15.12 ±2.02 years) with untreated primary hypertension, with excluded overt inflammation, we evaluated: neutrophils (NEU; 1000/μl), lymphocytes (LYM; 1000/μl), platelets (PLT; 1000/μl), mean platelet volume (MPV; fl), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), ABPM (OSCAR 2 SUNTECH), and selected clinical and biochemical parameters. The control group consisted of 20 healthy children (15.55 ±2.27 years).ResultsChildren with primary hypertension had (p < 0.01) higher 24-hour systolic, diastolic and mean blood pressure, systolic and diastolic blood pressure loads, and pulse pressure. Hypertensive children did not differ in inflammatory indicators (NEU, LYM, PLT, MPV, NLR, PLR) from the control group. In 54 hypertensive children we found the following correlations: between office systolic and diastolic blood pressure and MPV (r = 0.35, p = 0.011, r = 0.36, p = 0.008), between 24-hour ambulatory mean arterial pressure Z-score and NLR (r = 0.30, p = 0.030), 24-hour systolic blood pressure load and NLR (r = 0.38, p = 0.005), plasma renin activity and neutrophil count, NLR, PLR (r = 0.47, p = 0.016, r = 0.64, p < 0.001, r = 0.42, p = 0.033), urinary albumin loss and neutrophil count, NLR (r = 0.46, p = 0.001 and r = 0.42, p = 0.003). Multivariate analysis revealed that office SBP Z-score was related to MPV (β = 0.35, p = 0.008) and albuminuria to neutrophil count (β = 0.62, p = 0.018).ConclusionsIn children with primary arterial hypertension there may be a relation between blood pressure, urinary albumin loss, and subclinical inflammation.

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

“…There was no significant association between LMR and early pregnancy outcome at the range of more than 2. 19. The blood routine examination is a easily measurable and available method to reflect the general inflammatory status [21].…”

“…Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocytemonocyte ratio (LMR) are a series of new parameters derived from complete blood counting reflecting inflammatory status. Because of its availability and extensive use, accumulating studies have been reported that these inflammation-related parameters are pretty relative with the prognosis and genesis of many diseases [19,20]. Therefore, we sought to evaluate the associations of aforementioned indexes and the early pregnancy outcome in women with early threatened abortion.…”

Markers of endothelial injury and subclinical inflammation in children and adolescents with primary hypertension

“…Over the last decades, a vast number of studies have implicated endothelial dysfunction in the progression of atherosclerosis and target organ damage in primary hypertension [3, 6, 7]. Several biomarkers have been established to reflect the status of subclinical inflammation in cardiovascular diseases, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, and complete blood count-derived indices [8].…”

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

“…Several studies have shown that NLR is elevated and related to poor clinical outcomes of cardiovascular disease in adults, including acute coronary syndrome, atherosclerosis, and heart failure [28][29][30]. However, few studies have looked at NLR levels in children with newly diagnosed hypertension [13,31]. In the current study, we found the neutrophil counts and NLR were signi cantly higher in hypertension children than healthy children, and the elevated NLR may re ect the upregulation of overall in ammatory and stress status in these children.…”

“…Moreover, Skrzypczyk and colleagues reported NLR correlated with 24-hour ambulatory mean arterial pressure levels in adolescent [13], which suggest that blood cell parameter may also be useful in pediatrics population. To date, no studies have investigated the possible link between NLR and target organ damage in hypertension children.…”