Complete Atrioventricular Blockade Secondary to Conventional-Release Verapamil in a Patient on Hemodialysis

Complete atrioventricular block during renal transplantation in a patient with Alport's syndrome: case report

“…These patients can develop abnormalities in heart conduction due to hyperkalemia or the use of calcium channel inhibitors like verapamil and diltiazem. [1][2][3][4] We report a case of complete atrioventricular block during renal transplantation surgery in a patient with chronic renal failure secondary to Alport's syndrome.…”

Verapamil and mild hyperkalemia in hemodialysis patients: A potentially hazardous association

“…5,6 Nevertheless, there are reports of complete atrioventricular blockade secondary to conventional and slow-release verapamil in patients on hemodialysis. 7,8 The liver function of the 3 patients was normal and the prescribed doses were similar to those recommended by the guidelines. There was no reason to suspect a drug overdose, although the quantity of verapamil in blood was measured in the first case only and was above the usual therapeutic range (but markedly below the toxic level).…”

“…The terminal elimination rate constant, clearance, volume of distribution, and bioavailability of verapamil are not significantly different between patients undergoing maintenance hemodialysis and normal subjects 5,6 . Nevertheless, there are reports of complete atrioventricular blockade secondary to conventional and slow‐release verapamil in patients on hemodialysis 7,8 …”