Complete and Prolonged Suppression of Symptoms and Consequences of Alcohol-Dependence Using High-Dose Baclofen: A Self-Case Report of a Physician

Ameisen, Olivier

doi:10.1093/alcalc/agh130

Cited by 212 publications

(121 citation statements)

References 25 publications

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“…However, the safety and the manageability of baclofen led researchers to test baclofen at higher doses. Two case reports showed a significant reduction of alcohol consumption achieved with high doses of baclofen, specifically up to 140 mg/day (Bucknam, 2007) and up to 270 mg/day (Ameisen, 2005). Moreover, the safety of baclofen at higher doses has been confirmed by a recent pilot laboratory study testing 80 mg baclofen in combination with intoxicating doses of alcohol in 18 non-treatmentseeking social drinkers who did not meet the criteria for alcohol dependence (Evans and Bisaga, 2009).…”

Section: Baclofenmentioning

confidence: 95%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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Drug addiction represents a major social problem where addicts and alcoholics continue to seek and take drugs despite adverse social, personal, emotional, and legal consequences. A number of pharmacological compounds have been tested in human addicts with the goal of reducing the level or frequency of intake, but these pharmacotherapies have often been of only moderate efficacy or act in a sub-population of humans. Thus, there is a tremendous need for new therapeutic interventions to treat addiction. Here, we review recent interesting studies focusing on gamma-aminobutyric acid receptors, voltage-gated ion channels, and transcranial magnetic stimulation. Some of these treatments show considerable promise to reduce addictive behaviors, or the early clinical studies or pre-clinical rationale suggest that a promising avenue could be developed. Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism.

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Section: Baclofenmentioning

confidence: 95%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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show abstract

“…In addition, case reports suggest that even high doses of baclofen (up to 270 mg/day) given for several weeks are well tolerated, reduce craving for alcohol, and are not associated with a potential for abuse. 27,28 On the basis of its efficacy in alcohol-dependent subjects, we hypothesized that baclofen would be a safe and effective alternative to benzodiazepines in the management of inhalant withdrawal and craving. The 3 patients included in this report presented to our center with a primary diagnosis of inhalant dependence.…”

Section: Discussionmentioning

confidence: 99%

Baclofen in the Management of Inhalant Withdrawal: A Case Series

Muralidharan¹,

Rajkumar²,

Mulla³

et al. 2008

Prim. Care Companion J. Clin. Psychiatry

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“…This followed his own case report. 2 His life and experiences with anxiety, alcohol and the loss of a medical career were an almost exact mirror image of my own.…”

Section: Presentationmentioning

confidence: 97%