Complete and Partial Electron Transfer Involving Coordinated NOx

Kaim, Wolfgang

doi:10.1016/bs.adioch.2014.10.007

Cited by 5 publications

(1 citation statement)

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“…The EPR spectra obtained by chemical reduction in MeCN/nBu 4 NPF 6 solutions (black lines in Figure S13A and B) perfectly matched the records of electrogenerated [3] + . The X-band EPR signal of [3] + resembles well the spectra of several {Ru(NO)} 7 systems known from the literature, for example, the extensively studied porphyrin complexes [Ru(OEP)(NO)(THF)], 61 [Ru(OEP)(NO)(py)], 62 or [Ru(TPP)(NO)(py)]. 63 The reduction with Fc* was also successfully used to generate the one electron reduced {Ru(NO)} S2).…”

Section: Synthesis Of Complexes the Complexes Trans-supporting

confidence: 64%

NO Releasing and Anticancer Properties of Octahedral Ruthenium–Nitrosyl Complexes with Equatorial 1H-Indazole Ligands

et al. 2018

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With the aim of enhancing the biological activity of ruthenium-nitrosyl complexes, new compounds with four equatorially bound indazole ligands, namely, trans-[RuCl(Hind)(NO)]Cl·HO ([3]Cl·HO) and trans-[RuOH(Hind)(NO)]Cl·HO ([4]Cl·HO), have been prepared from trans-[Ru(NO)(Hind)] ([2]). When the pH-dependent solution behavior of [3]Cl·HO and [4]Cl·HO was studied, two new complexes with two deprotonated indazole ligands were isolated, namely [RuCl(ind)(Hind)(NO)] ([5]) and [RuOH(ind)(Hind)(NO)] ([6]). All prepared compounds were comprehensively characterized by spectroscopic (IR, UV-vis, H NMR) techniques. Compound [2], as well as [3]Cl·2(CH)CO, [4]Cl·2(CH)CO, and [5]·0.8CHCl, the latter three obtained by recrystallization of the first isolated compounds (hydrates or anhydrous species) from acetone and dichloromethane, respectively, were studied by X-ray diffraction methods. The photoinduced release of NO in [3]Cl and [4]Cl was investigated by cyclic voltammetry and resulting paramagnetic NO species were detected by EPR spectroscopy. The quantum yields of NO release were calculated and found to be low (3-6%), which could be explained by NO dissociation and recombination dynamics, assessed by femtosecond pump-probe spectroscopy. The geometry and electronic parameters of Ru species formed upon NO release were identified by DFT calculations. The complexes [3]Cl and [4]Cl showed considerable antiproliferative activity in human cancer cell lines with IC values in low micromolar or submicromolar concentration range and are suitable for further development as potential anticancer drugs. p53-dependence of Ru-NO complexes [3]Cl and [4]Cl was studied and p53-independent mode of action was confirmed. The effects of NO release on the cytotoxicity of the complexes with or without light irradiation were investigated using NO scavenger carboxy-PTIO.

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Section: Synthesis Of Complexes the Complexes Trans-supporting

confidence: 64%

NO Releasing and Anticancer Properties of Octahedral Ruthenium–Nitrosyl Complexes with Equatorial 1H-Indazole Ligands

et al. 2018

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Analysis of Multiple Redox Sites in Complexes [M(C₅Me₅)(Q)(NO)]ⁿ, M=Ru or Os, Q=o‐Quinones

Scherer

Hartenbach

Lissner

et al. 2021

Zeitschrift anorg allge chemie

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Neutral complexes [M II (C 5 Me 5 )(Q 2À )(NO + )] with M = Ru or Os and the catecholates Q 2À with 3,5-di-tert-butyl (dtbc) or 3,4,5,6tetrachloro substituents (tcc) were identified with the oxidation and charge states indicated. Reversible electron transfer was analyzed spectroelectrochemically (EPR, UV-vis-NIR, IR), supported by DFT calculations. Reversible reduction was observed for [Ru(C 5 Me 5 )(tcc)(NO)] to occur on the nitrosyl ligand to yield the NO radical complex [Ru II (C 5 Me 5 )(tcc 2À )(NO * )] À , whereas the stepwise oxidation yielded o-semiquinone cations, [M II-(C 5 Me 5 )(Q * À )(NO + )] + , and dications. The metals remained in the stable low-spin d 6 states, Ru II and Os II , respectively. Redox potentials were found to depend strongly on the donor or acceptor substitution pattern at Q n .

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Nitrosyl- versus nitroxyl-cobalamin?

et al. 2019

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Complete and Partial Electron Transfer Involving Coordinated NOx

Cited by 5 publications

References 96 publications

NO Releasing and Anticancer Properties of Octahedral Ruthenium–Nitrosyl Complexes with Equatorial 1H-Indazole Ligands

NO Releasing and Anticancer Properties of Octahedral Ruthenium–Nitrosyl Complexes with Equatorial 1H-Indazole Ligands

Analysis of Multiple Redox Sites in Complexes [M(C₅Me₅)(Q)(NO)]ⁿ, M=Ru or Os, Q=o‐Quinones

Nitrosyl- versus nitroxyl-cobalamin?

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Complete and Partial Electron Transfer Involving Coordinated NOx

Cited by 5 publications

References 96 publications

NO Releasing and Anticancer Properties of Octahedral Ruthenium–Nitrosyl Complexes with Equatorial 1H-Indazole Ligands

NO Releasing and Anticancer Properties of Octahedral Ruthenium–Nitrosyl Complexes with Equatorial 1H-Indazole Ligands

Analysis of Multiple Redox Sites in Complexes [M(C5Me5)(Q)(NO)]n, M=Ru or Os, Q=o‐Quinones

Nitrosyl- versus nitroxyl-cobalamin?

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Analysis of Multiple Redox Sites in Complexes [M(C₅Me₅)(Q)(NO)]ⁿ, M=Ru or Os, Q=o‐Quinones