Complete agenesis of the corpus callosum in paranoid schizophrenia—a case report

Abstract

Corpus callosum agenesis is a rare condition and is sometimes associated with schizophrenia. The co‐existence of these two conditions adds value to the neurodevelopmental theory of schizophrenia.

Complete agenesis of corpus callosum with a rare neuropsychiatric presentation: A case report

“…Although many cases of ACC might be asymptomatic, in cases who present with clinical symptoms CC is usually atrophic or absent [1 , [8] , [9] , [10] . There are growing data which show that anatomical brain abnormalities can accompany psychiatric manifestations such as delusion, psychosis, and hallucinations [2 , 11 , 12] .…”

“…There is the possibility that abnormalities of CC correlate with the pathogenesis of schizophrenia considering that this structure is responsible for interhemispheric data transfer; as a result, disconnection may arise between two hemisphere psychiatric symptoms. Furthermore, CC has connections with other structures such as the hippocampus and cingulate cortex which are also involved in schizophrenia patients [12] . Some previous reports declared that schizophrenia and delusions usually happened in patients with partial agenesis [1 , 11 , 16] , while some other reported complete agenesis of CC such as our case [1 , 17] .…”