Complete Ablation of Porcine Esophageal Epithelium Using a Balloon-based Bipolar Electrode

Present Status of Photodynamic Therapy for High-Grade Dysplasia in Barrett??s Esophagus

“…[94][95][96] This series of 29 patients found an 86% rate in the destruction of Barrett's HGD, although it is not clear that all glandular mucosa was eliminated in these patients. 105 Progression to invasive carcinoma was seen in 14% of patients, and 1 patient experienced a treatment related perforation and died of complications after esophageal resection surgery.…”

DDW Report 2004 New Orleans: Reflux Disease and Barrett’s Esophagus

“…Other series reported on a combination of PDT and EMR in 33 cases [66] and 22 cases [67]. A new balloon-based bipolar electrode system for BE ablation was presented in an animal study [68] and three clinical cases [69].…”

Ablating Barrett's metaplastic epithelium: are the techniques ready for clinical use?

“…Examples of these techniques are laser photocoagulation, multipolar electrocoagulation, argon plasma coagulation, radiofrequency ablation, cryoablation, and photodynamic therapy. [8][9][10][11][12][13] These therapies are all aimed at inducing a controlled injury to the superficial oesophageal wall layers thereby ablating the metaplastic epithelium while maintaining the integrity of the submucosa and deeper wall layers. Under aggressive acid suppressing therapy, the oesophagus is then allowed to heal in an acid free environment, promoting restoration of the normal squamous mucosa.…”