Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome

Carolis, Sara De; Botta, Angela; Santucci, S.; Salvi, Silvia; Moresi, Sascia; Pasquo, E. di; Sordo, Gelsomina Del; Martino, Carmelinda

doi:10.1177/0961203312444172

Cited by 50 publications

(34 citation statements)

References 12 publications

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“…These factors eventually lead to abortion, placental disease, fetal growth restriction, and other adverse pregnancy outcomes. [10111213]…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion

Tao

et al. 2017

Chinese Medical Journal

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Background:Antiphospholipid syndrome (APS)-related immune factors are considered as an important cause of recurrent spontaneous abortion (RSA). Anticoagulant and anti-inflammatory treatments are believed to effectively improve adverse pregnancy outcomes by affecting the abnormal autoimmune response of the maternal-fetal interface. The aim of this study was to observe the clinical characteristics and treatment outcomes of anticoagulant regimens and anti-inflammatory plus anticoagulation regimens for APS-related RSA.Methods:APS-related RSA cases from September 2011 to September 2016 at Peking University Third Hospital were retrospectively analyzed. The patients were assigned to study group (anti-inflammation plus anticoagulation) and control group (simple anticoagulation). The incidence of repeat abortion, the incidence of placental dysfunction, the gestational weeks of pregnancy, and the mean weight of the fetus were observed.Results:The pregnancy and neonatal outcome indicators of the repeat pregnancy loss rate (11.11% vs. 22.70%), placental dysfunction-related diseases (6.35% vs. 15.60%), the mean birth weight of infants born after 24 weeks gestation (3152.41 ± 844.67 g vs. 2765.76 ± 816.40 g), full-term delivery weight (3456.28 ± 419.79 g vs. 3076.18 ± 518.79 g), the proportions of low birth weight infants (12.70% vs. 21.98%), and small for gestational age (6.35% vs. 14.18%) differed significantly between the study and control groups (all P < 0.05). The incidence of preterm delivery, term delivery, and stillbirth was not significantly different between the two groups, and there was no significant difference between the study and control groups in gestational age at birth (37.6 ± 3.3 weeks vs. 36.9 ± 3.2 weeks; P > 0.05).Conclusion:The anti-inflammatory and anticoagulation regimen is more effective than the simple anticoagulation regimen in the treatment of APS recurrent abortion.

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“…These factors eventually lead to abortion, placental disease, fetal growth restriction, and other adverse pregnancy outcomes. [10111213]…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion

Tao

et al. 2017

Chinese Medical Journal

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“…Our contribution to this research is demonstrated in a recent published report in which we searched for the role of complement activation in 47 pregnancies complicated by either PAPS or APS associated with other autoimmune diseases [35]. The correlation of hypocomplementemia, defined as C3 <90 mg/dl and/or C4 <10mg/dl, with adverse obstetric outcome was highlighted.…”

Section: Complement Activation In Healthy and Aps Pregnancymentioning

confidence: 97%

Role of the complement in pregnancy with antiphospholipid syndrome: mechanisms of pathogenesis and clinical aspects

Carolis¹,

Vitucci²,

Garofalo³

et al. 2013

International Journal of Clinical Rheumatology

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“…In order to investigate the predictive value of serum C3 and C4 complement component in pregnancy, a prospective study of 47 APS pregnancies was performed by our group [41]. Pregnancy outcome was analyzed in terms of: fetal loss, preterm delivery (≤ 34 gestational weeks), FGR, birth weight <2500 g and preeclampsia.…”

Section: Predictive Value Of Hypocomplementemiamentioning

confidence: 99%

“…Other investigators [42,43], evaluated in pregnancies complicated with PAPS, the association between serum complement levels (C3 and C4) and obstetric complications: fifty-seven pregnancies in primary APS were compared with a group of 175 healthy women. The PAPS group showed significantly lower levels of C3 and C4 in each trimester in comparison with healthy women, but no association was found between hypocomplementemia and the obstetric investigation…”

Section: Predictive Value Of Hypocomplementemiamentioning

confidence: 99%

Predictors of Pregnancy Outcome in Antiphospholipid Syndrome: A Review

Tabacco¹,

Salvi²

2016

J Allergy Ther

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Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome

Abstract: Hypocomplementemia could be considered a novel prognostic factor for pregnancy outcome in APS patients.

Cited by 50 publications

References 12 publications

Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion

Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion

Role of the complement in pregnancy with antiphospholipid syndrome: mechanisms of pathogenesis and clinical aspects

Predictors of Pregnancy Outcome in Antiphospholipid Syndrome: A Review

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