Complementation of the Host Range Restriction of Southern Cowpea Mosaic Virus in Bean by Southern Bean Mosaic Virus

Hacker, David L.; Fowler, Benjamin C.

doi:10.1006/viro.1999.0072

Cited by 24 publications

(16 citation statements)

References 29 publications

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“…Recently, experiments were carried out to determine whether the host range restriction of SCPMV in bean plants could be complemented in trans by a related virus such as SBMV (37). It was demonstrated that SCPMV accumulates in the inoculated and systemically infected leaves of bean plants following coinoculation with SBMV.…”

Section: Gene Products and Their Functionsmentioning

confidence: 99%

Sobemoviruses

Tamm

Truve

2000

J Virol

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Section: Gene Products and Their Functionsmentioning

confidence: 99%

Sobemoviruses

Tamm

Truve

2000

J Virol

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“…However, in spite of the extensive divergence among different virus groups of the movement mechanisms derived from these interactions, they appear to be able to facilitate the transport of a wide range of heterologous viruses. Thus, many viruses belonging to different taxonomic groups have been shown to be able to complement one another's movement functions in nonhost plants (28,29,42,62). Moreover, several studies have shown that different viral proteins, expressed from transgenes (for examples, see references 14, 25, and 32), heterologous sequences cloned in defective genomes (for examples, see references 18,22,44,55, and 61), or cotransfected plasmids (for examples, see references 1 and 21), can functionally replace nonhomologous proteins from other viruses, sometimes resulting in an extension of their virus host ranges.…”

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confidence: 99%

Host-Specific Involvement of the HC Protein in the Long-Distance Movement of Potyviruses

Sáenz

Salvador

Simón‐Mateo

et al. 2002

J Virol

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Plum pox virus (PPV) is a member of the Potyvirus genus that, in nature, infects trees of the Prunus genus.Although PPV infects systemically several species of the Nicotiana genus, such as N. clevelandii and N. benthamiana, and replicates in the inoculated leaves of N. tabacum, it is unable to infect systemically the last host. The long-distance movement defect of PPV was corrected in transgenic tobacco plants expressing the 5-terminal region of the genome of tobacco etch virus (TEV), a potyvirus that infects systemically tobacco. The fact that PPV was unable to move to upper noninoculated leaves in tobacco plants transformed with the same TEV transgene, but with a mutation in the HC protein (HC-Pro)-coding sequences, identifies the multifunctional HC-Pro as the complementing factor, and strongly suggests that a defect in an HC-Pro activity is responsible for the long-distance movement defect of PPV in tobacco. Whereas PPV HC-Pro strongly intensifies the symptoms caused by potato virus X (PVX) in the PPV systemic hosts N. clevelandii and N. benthamiana, it has no apparent effect on PVX pathogenicity in tobacco, supporting the hypothesis that long-distance movement and pathogenicity enhancement are related activities of the potyviral HC proteins. The movement defect of PPV in tobacco could also be complemented by cucumber mosaic virus in a mixed infection, demonstrating that at least some components of the long-distance machinery of the potyviruses are not strictly virus specific. A general conclusion of this work is that the HC-Pro might be a relevant factor for controlling the host range of the potyviruses.

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“…, 1988; Dasgupta et al. , 2001; Hacker and Fowler, 2000; Hamilton and Nichols, 1977; Spitsin et al. , 1999), seed transmission (Kuhn and Dawson, 1973), specific infectivity (Chiba et al.…”

Section: An Overview Of Synergisms and Transcomplementationmentioning

confidence: 99%

Transcomplementation and synergism in plants: implications for viral transgenes?

Latham¹,

Wilson²

2007

Molecular Plant Pathology

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In plants, viral synergisms occur when one virus enhances infection by a distinct or unrelated virus. Such synergisms may be unidirectional or mutualistic but, in either case, synergism implies that protein(s) from one virus can enhance infection by another. A mechanistically related phenomenon is transcomplementation, in which a viral protein, usually expressed from a transgene, enhances or supports the infection of a virus from a distinct species. To gain an insight into the characteristics and limitations of these helper functions of individual viral genes, and to assess their effects on the plant-pathogen relationship, reports of successful synergism and transcomplementation were compiled from the peer-reviewed literature and combined with data from successful viral gene exchange experiments. Results from these experiments were tabulated to highlight the phylogenetic relationship between the helper and dependent viruses and, where possible, to identify the protein responsible for the altered infection process. The analysis of more than 150 publications, each containing one or more reports of successful exchanges, transcomplementation or synergism, revealed the following: (i) diverse viral traits can be enhanced by synergism and transcomplementation; these include the expansion of host range, acquisition of mechanical transmission, enhanced specific infectivity, enhanced cell-to-cell and long-distance movement, elevated or novel vector transmission, elevated viral titre and enhanced seed transmission; (ii) transcomplementation and synergism are mediated by many viral proteins, including inhibitors of gene silencing, replicases, coat proteins and movement proteins; (iii) although more frequent between closely related viruses, transcomplementation and synergism can occur between viruses that are phylogenetically highly divergent. As indicators of the interoperability of viral genes, these results are of general interest, but they can also be applied to the risk assessment of transgenic crops expressing viral proteins. In particular, they can contribute to the identification of potential hazards, and can be used to identify data gaps and limitations in predicting the likelihood of transgene-mediated transcomplementation.

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Complementation of the Host Range Restriction of Southern Cowpea Mosaic Virus in Bean by Southern Bean Mosaic Virus

Cited by 24 publications

References 29 publications

Sobemoviruses

Sobemoviruses

Host-Specific Involvement of the HC Protein in the Long-Distance Movement of Potyviruses

Transcomplementation and synergism in plants: implications for viral transgenes?

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