Complementation at the am locus of Neurospora crassa: a reaction between different mutant forms of glutamate dehydrogenase

Interallelic recombination at the his-5 locus in Neurospora crassa

“…Since it has been demonstrated in other genes that complementation occurs at the protein level (Woodward, 1959;Fincham and Coddington, 1963) it is not unreasonable to assume that the position in the genetic map of the sites of difference of mutants of each complementation group may reflect in some way the structure and geometry of the enzyme produced. In the his-5 gene the non-complementing mutants appear to be scattered throughout the length of the genetic map.…”

L-Asparagine degradation in saccharomyces cerevisiae: Genetic control and biochemical properties of yeast L-asparaginase

“…The interpretation of such complementation patterns has been extensively studied (25,27,107,122). Enzymes that participate in interallelic complementation are multimeric proteins consisting of two or more identical polypeptide chains (monomers) (20,25 During the isolation of segregants that contained the asparaginase mutations in cells of opposite mating type to those in which the mutations were originally induced, the trp4 gene seemed to appear in combination with the asparaginase mutations more frequently than would be expected if the two genes were segregating randomly.…”

Amber Mutants of Bacteriophage T4D: Their Isolation and Genetic Characterization

“…The currently accepted explanation for intragenic complementation (Woodward 1959;Fincham and Coddington 1963) involves the interaction of the protein products of genes. Hence, the most obvious explanation for the systematic absence of intragenic complementation among amber mutants is that such mutations lead either to no polypeptide chain synthesis or to the synthesis of a drastically altered Figure 3 The three linkage groups of the historical map are shown in the inner circle.…”