Complementary vibrational spectroscopy

Abstract

Vibrational spectroscopy, comprised of infrared absorption and Raman scattering spectroscopy, is widely used for label-free optical sensing and imaging in various scientific and industrial fields. The two molecular spectroscopy methods are sensitive to different types of vibrations and provide complementary vibrational spectra, but obtaining complete vibrational information with a single spectroscopic device is challenging due to the large wavelength discrepancy between the two methods. Here, we demonstrate simultaneous infrared absorption and Raman scattering spectroscopy that allows us to measure the complete broadband vibrational spectra in the molecular fingerprint region with a single instrument based on an ultrashort pulsed laser. The system is based on dual-modal Fourier-transform spectroscopy enabled by efficient use of nonlinear optical effects. Our proof-of-concept experiment demonstrates rapid, broadband and high spectral resolution measurements of complementary spectra of organic liquids for precise and accurate molecular analysis.

Comparison of Raman and Near-Infrared Chemical Mapping for the Analysis of Pharmaceutical Tablets

“…17 Raman and NIR spectroscopy are complementary techniques where functional groups that exhibit an intense Raman signal, generally give a weak NIR response and vice versa. 18,19 The sensitivity of each technique for a particular formulation will therefore depend on the chemical nature of the individual components.…”

Worthwhile Relevance of Infrared Spectroscopy in Characterization of Samples and Concept of Infrared Spectroscopy-Based Synchrotron Radiation

“…e interferometer consists of a moving mirror which changes the IR light distribution when it passes through the sample [27,28]. e resulting signal called, "interferogram," is recorded directly, signifying the light output as a function of mirror position [29].…”

Intrinsic molecular vibration and rigorous vibrational assignment of benzene by first-principles molecular dynamics

“…A major task in classical spectroscopy study is to develop suitable force fields for the vibrational mode analysis and frequency calculation [6][7][8] . Spectral measurement is restricted by the selection rules in quantum transition which results the available frequency information by experiment is limited 9 . The insufficient experimental data may lead to considerable uncertainty in vibrational assignment.…”