Complementary Therapies in Inflammatory Bowel Diseases

Yanai, Henit; Salomon, Nir; Lahat, Adi

doi:10.1007/s11894-016-0537-6

Cited by 20 publications

(16 citation statements)

References 78 publications

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“…In the inflamed mucosa, activation of CB1 and CB2 receptors can reduce the hypermotility associated with inflammation. Cannabinoids also exert analgesic, anti-nausea, and anti-diarrheal effects in patients with IBD [43,[45][46][47]. Figure 3 shows the effects of CS or its derivatives in the pathophysiologic aspects of IBD.…”

Section: Cannabis Sativa and Endocannabinoid Systemmentioning

confidence: 99%

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Carvalho

Souza

Marqui

et al. 2020

IJMS

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Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent gastrointestinal condition, including mainly ulcerative colitis (UC) and Crohn’s disease (CD). Cannabis sativa (CS) is widely used for medicinal, recreational, and religious purposes. The most studied compound of CS is tetrahydrocannabinol (THC) and cannabidiol (CBD). Besides many relevant therapeutic roles such as anti-inflammatory and antioxidant properties, there is still much controversy about the consumption of this plant since the misuse can lead to serious health problems. Because of these reasons, the aim of this review is to investigate the effects of CS on the treatment of UC and CD. The literature search was performed in PubMed/Medline, PMC, EMBASE, and Cochrane databases. The use of CS leads to the improvement of UC and CD scores and quality of life. The medical use of CS is on the rise. Although the literature shows relevant antioxidant and anti-inflammatory effects that could improve UC and CD scores, it is still not possible to establish a treatment criterion since the studies have no standardization regarding the variety and part of the plant that is used, route of administration and doses. Therefore, we suggest caution in the use of CS in the therapeutic approach of IBD until clinical trials with standardization and a relevant number of patients are performed.

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Section: Cannabis Sativa and Endocannabinoid Systemmentioning

confidence: 99%

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Carvalho

Souza

Marqui

et al. 2020

IJMS

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“…Complementary and alternative medicine (CAM) refers to health-care strategies developed separately to that of Western or conventional mainstream medicine, with the term ‘complementary’ implying usage of these therapies in addition to conventional medicine [41]. In the past, many IBD professionals have avoided CAM because of a lack in supporting scientific evidence, despite reports indicating that upwards of 50% of IBD patients utilize non-conventional therapies (i.e.…”

Section: Complementary and Alternative Medicine (Cam)mentioning

confidence: 99%

“…Moreover, advanced research technologies are working to reshape the face of many CAM strategies (e.g., genetically engineered probiotics) into those of precise, next-generation CAM (NG-CAM) systems, designed for treatment of specific disease states, including IBD. Still, the integration of CAM/NG-CAM into any medical management plan, whether intended as short- or long-term, should be tailored to each individual patient, and performed by an experienced practitioner capable of evaluating all facets of the available evidence with regard to benefits, safety and cost [41]. …”

Section: Complementary and Alternative Medicine (Cam)mentioning

confidence: 99%

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Complementary and Alternative Medicine Strategies for Therapeutic Gut Microbiota Modulation in Inflammatory Bowel Disease and their Next-Generation Approaches

Basson

Lam

Cominelli

2017

Gastroenterology Clinics of North America

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SUMMARY The human gastrointestinal tract is resident to a vastly diverse microbial consortium that co-exists through strict rules of invasion, dominance, resilience and succession. While some members possess stronger capabilities for survival than others, each one retains a genome characteristic of their bacterial denomination which subsequently determines survival and ultimately the composition of a human gut microbiome. Collective evidence advocates the concept of gut microbiota modulation via dietary compounds, with or without nutraceutical supplementation. However, consistent reports of strong individuality in responsiveness suggest that initial composition of host microbiota mediates the effect of nutrition modulation. There is also a strong potential for the interaction between mind and microbe to influence responsiveness, although mechanistic understanding of these complex exchanges remains in its infancy at best. Synthetic stool for FMT is a next-generation microbiome-therapy shown effective in treating C.difficile [417] which could provide a feasible alternative to current methods for patients with IBD. Nevertheless, studies investigating optimum timing for FMT administration are essential. Animal and human studies are only starting to highlight the Pandora of interactions that endure between members of gut microbiome, their associated metabolites, dietary compounds, as well as host neurological and immune systems, all of which characteristic to each individual. Advanced research technologies have excelled the scientific evidence in support of CAM and toward generating NG-CAM systems designed for treatment of specific disease states, such as IBD. While the majority of envisioned NG-CAM strategies presently exist in their experimental and discovery phases, many show promise for future clinical application.

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“…However, these treatments don't cure the disease and are not fully effective because patients are either non-primary responders or secondarily lose response (Ben-Horin et al, 2014). In addition, these drugs are not devoid of sideeffects (Bonovas et al, 2016) thus explaining that patients are reluctant and not compliant with these treatments (Lenti & Selinger, 2017), and are among the highest users of complementary and alternative medicines (Yanai et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Is-there a place for vagus nerve stimulation in inflammatory bowel diseases?

Bonaz

2018

Bioelectron Med

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The vagus nerve (VN), the longest nerve of the organism that innervates the gastrointestinal tract, is a mixed nerve composed of 80% of afferent and 20% of efferent fibers. The VN has anti-inflammatory properties, in particular an anti-TNFα effect through the cholinergic anti-inflammatory pathway. The VN is a key component of the autonomic nervous system, i.e. the parasympathetic nervous system. An imbalance of the autonomic nervous system, as represented by a low vagal tone, is described in many diseases and has a pro-inflammatory role. Inflammatory bowel diseases (IBD) are chronic disorders of the gastro-intestinal tract where TNFα is a key cytokine. VN stimulation (VNS), classically used for the treatment of drug resistant epilepsy and depression, would be of interest in the treatment of IBD. We have recently reported in a 6 month follow-up pilot study that VNS improves active Crohn's disease. Preliminary data of another pilot study confirm this interest. Similarly, VNS has recently been reported to improve rheumatoid arthritis, another TNFα mediated disease. Bioelectronic Medicine, as represented by VNS, opens new therapeutic avenues in the treatment of such chronic inflammatory disorders. In the present manuscript, we will focus on the interest of VNS in IBD.

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Complementary Therapies in Inflammatory Bowel Diseases

Cited by 20 publications

References 78 publications

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

Complementary and Alternative Medicine Strategies for Therapeutic Gut Microbiota Modulation in Inflammatory Bowel Disease and their Next-Generation Approaches

Is-there a place for vagus nerve stimulation in inflammatory bowel diseases?

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