Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy

Kiseleva, Elena B.; Gubarkova, Ekaterina V.; Dudenkova, Varvara V.; Timashev, P. S.; Kotova, Svetlana; Timofeeva, Lidia B.; Kirillin, Mikhail; Belkova, G. V.; Соловьева, А. Б.; Streltsova, Olga; Gladkova, Natalia D.

doi:10.17691/stm2017.9.1.01

Cited by 9 publications

(11 citation statements)

References 13 publications

(17 reference statements)

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“…Twenty relevant articles on OCT in BC were identified in the systematic search, of which two were overlapping study populations (Table 2) [1,3,[5][6][7][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Bladder Cancermentioning

confidence: 99%

“…Besides qualitative assessment, quantitative analysis of changes in OCT cross-polarization backscattering and integral depolarization factor reached a diagnostic accuracy for BC of 75% [5,6,23]. However, quantitative analysis of the μ OCT was not feasible in ex vivo for BC diagnosis and grading.…”

Section: Bladder Cancermentioning

confidence: 99%

“…Statistical, structural, and spectral texture analyses of OCT images have been applied for computer-aided tumor detection [3,4]. Quantification of OCT signal depolarization may also serve for automated diagnosis [5,6]. Furthermore, the decrease in OCT signal with tissue depth, quantified by the attenuation coefficient (μ OCT , mm −1 ), has been explored for cancer diagnosis and histologic grading [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

Freund

Buijs

Heijink

et al. 2018

SN Compr. Clin. Med.

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Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT in humans up to December 2017. Reviews were excluded. Case reports were excluded, unless they presented a landmark in the development of OCT. Results Out of 878 articles, 17 relevant articles on bladder, seven on kidney, five on upper urinary tract, four on prostate, and two on penile cancer were included. In these organs, in vivo OCT imaging is feasible with potential for qualitative and quantitative diagnosis, grading and staging in specific organs. The development of OCT has reached IDEAL stage 2b with 2b level of evidence. Relevant articles on testis cancer were lacking. Conclusion OCT allows for non-or minimally invasive cancer diagnosis in the bladder, upper urinary tract, kidney, prostate, and penis. In some organs, OCT also may enable histologic grade and stage prediction. However, the current evidence is still at an exploratory level. With regard to the potential additional value of OCT in comparison to the current diagnostic pathways, OCT could become a diagnostic replacement or add-on test for urothelial carcinoma, penile carcinoma, and renal masses. Further research in these conditions should be encouraged.

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Section: Bladder Cancermentioning

confidence: 99%

Section: Bladder Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

Freund

Buijs

Heijink

et al. 2018

SN Compr. Clin. Med.

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“…This is available at the level of the general tissue architectonics based on the di®erences in tissues backscattering properties. If tissue components exhibit cross-scattering or birefringence (for example, collagen or myelin¯bers), they can be analyzed separately by using polarization-sensitive modality of OCT, 22 including cross-polarization (CP) OCT. 23,24 Despite signi¯cant worldwide experience in applying the OCT method in many¯elds of medicine, including urology, this study reports its¯rst use for investigating the walls of the female urethra in patients with UPS. Until now, the OCT has been applied for di®erentiating in°ammatory and tumor processes of the bladder, 24 detecting prostate cancer for determining the boundaries of resection, 25 and cancer of the ureter.…”

Section: Introductionmentioning

confidence: 98%

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Kiseleva

Moiseev

Kuyarov

et al. 2020

J. Innov. Opt. Health Sci.

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The paper presents the results of a study of the female urethra in cases of urethral pain syndrome (UPS) and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography (CP OCT). Urethral wall structure was studied in 86 patients; 233 CP OCT images were collected. A comparative qualitative analysis of three groups of CP OCT images — “norm”, “Inflammation” and “UPS” — identified that despite the absence of a clear inflammatory factor in the patient’s examination, the urethral tissues in UPS were in an altered state. The changes in the urethral wall with UPS and in cases of inflammation were similar. Using a point scale, three experts independently performed visual scoring of the CP OCT images. Three parameters: epithelial contrast, cavities and the minimum signal depth in the co-channel were evaluated. It was found that, individually, the parameters correlate only weakly with the diagnosis. Area under the receiver operating characteristic (ROC) curve was from 0.51 to 0.78. The joint use of a number of visual signs has a greater diagnostic value than the use of the criteria individually. Area under the ROC curve using the developed cumulative criterion reached up to 0.87–0.89. This study could form the basis of a scoring system for assessing the state of the urethral tract using CP OCT images in real time. The CP OCT method provides information on the state of urethral tissues that cannot be obtained with traditional cystoscopy.

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“…Ñå÷îâèé ì³õóð ã³ñòîëîã³÷íî ñêëàäàºòüñÿ, ïåðåâàaeíèì ÷èíîì, ³ç ïîõ³äíèõ ìåçîäåðìè: ïåðåõ³äíèé åï³òåë³é ³ âëàñíà ïëàñòèíêà ñëèçîâî¿ îáîëîíêè, ïó÷êè ãëàäêèõ ì³îöèò³â ì'ÿçîâî¿ îáîëîíêè ç âèðàaeåíèìè ïðîøàðêàìè ïóõêî¿ ÑÒ, ù³ëüíà ÑÒ àäâåíòèö³é-íî¿ îáîëîíêè ç âåëèêîþ ê³ëüê³ñòþ òîâñòèõ åëàñòè÷íèõ âîëîêîí [9].…”

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Manifestations of Urinary System Pathology at Young Age Patients With Temporоmandibular Joint Diseases

Kryzhanivska

2019

Med. Sci. of Ukr.

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Relevance. In recent years, many have been devoted to the problem of the temporomandibular joint (TMJ) diseases, in which the attention is paid to the widespread pathology of TMJ at young people, which develops against the background of genetically-determined weakness of connective tissue (CT), which is also present occurrence of various concomitant diseases of polygenic-multifactorial nature, including the organs of the urinary system (US). Objective. To investigate the manifestations of US pathology in young patients with TMJ diseases. Materials and methods. The study involved 32 patients (m-4, w-28) with diseases of the TMJ, whose average age was 31.6 ± 7.7 years, who were treated at the Dental Medical Center of the Bogomolets NMU. Manifestations of US pathology in patients of this group have been investigated. Examination of patients was performed according to the classical method of examination of patients with diseases of the TMJ. The orthopantomography with examination of the mandibular heads, open mouth X-ray by Parma, computed tomography or MRI scan, iridobiomicroscopy were obligatory. The presence of pathology of US was founding out from the anamnesis vitae, the patient was referred for consultation to a nephrologist. Ultrasound of the kidneys, urinary tract, urine tests were performed for all examined patients. The obtained laboratory data were referenced in the International System of Units and processed by variational statistics using MedStat and EZR v.1.35 (Saitama Medical Center, Jichi Medical University, Saitama, Japan, 2017), which is a graphical interface to RFSC (The R Foundation for Statistical Computing, Vienna, Austria). Results. The following manifestations of TMJ pathology were found in young patients with US diseases: chronic cystitis – 37.5% of cases, oxalate or urinary crystalluria – 37.5 %, nephroptosis – 9.4 %, urolithiasis – 6.3 %, chronic pyelonephritis – 6.3 %, double kidney – 3.1 %. Structural local or chromatic changes of the iris stroma in the projection region of the kidney (75 %) and bladder (43.6 %) in young patients with TMJ diseases showed a congenital weakness of the CT of these organs and a tendency to develop pathology of the US. Changes in urine tests were mainly in the form of oxalate crystalluria (34.4 %), increase specific gravity (15.6 %), proteinuria (9.4 %), which further confirmed the present pathology of the urinary system. Conclusions. The manifestations of developmental abnormalities and other kidney and bladder diseases found in young patients with TMJ disease suggest that there is a correlation between flow of pathological processes in the TMJ and US, which may be based on changes in the CT system. When planning the treatment of young patients with TMJ diseases and pathology of US, medicines that do not affect the urinary system and do not provoke exacerbation of the disease should be prescribed. In the presence of pathology of the kidneys and/or urinary tract, the ultrasound of this system should be prescribed in consultation with a nephrologist.

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Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy

Cited by 9 publications

References 13 publications

Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Manifestations of Urinary System Pathology at Young Age Patients With Temporоmandibular Joint Diseases

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