Complementary Medicine Use by Patients With Inflammatory Bowel Disease

Hilsden, Robert J.; Scott, Cathie; Verhoef, Marja J.

doi:10.1111/j.1572-0241.1998.208_a.x

Cited by 103 publications

(91 citation statements)

References 7 publications

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“…Herbal remedies are the single most used type of complementary and alternative medicine [26,27]. Usage is particularly common in patients with irritable bowel syndrome and inflammatory bowel disease [26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Shin

Kim

et al. 2018

Digestion

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Background: Gamisoyo-San decoction (GSS), a traditional Chinese medicine, has been used to treat various gastrointestinal (GI) symptoms and diseases such as functional dyspepsia. The purpose of this study was to investigate the effect of GSS on GI motility functions in mice. Methods: Percent intestinal transit rate (ITR%) and gastric emptying (GE) values were measured using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). Results: In normal mice, GSS (0.01–1 g/kg) induced higher GE values than non-treated controls. Also, GSS could increase GE in loperamide-induced and cisplatin-induced GE delay models. In addition, GSS increased ITR% in a dose-dependent manner. Loperamide decreased ITR% and GSS recovered this loperamide-induced decrease in ITR%. To examine the effect of GSS on GMD, we used acetic acid (AA)-induced and streptozotocin (STZ)-induced mouse GMD models. The AA mouse model showed a significant decrease in ITR%. However, intragastric treatment with GSS significantly recovered this inhibition. Furthermore, STZ-induced diabetic mice showed a significant reduction in ITR%, which was also significantly inhibited by GSS. Conclusion: These results demonstrate that GSS can modulate bowel activity and that it could be used as a gastroprokinetic agent in the treatment of GI motility diseases.

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Section: Discussionmentioning

confidence: 99%

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Shin

Kim

et al. 2018

Digestion

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“…Drug therapy aims at altering the course of disease, reducing symptoms, and improving health-related quality of life (HRQOL) [6,7,8,9]. Therefore, strategies, including complementary pharmacological approaches and psychosocial support, are commonly used by patients with IBD [10,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

The Impact of a Ten-Week Physical Exercise Program on Health-Related Quality of Life in Patients with Inflammatory Bowel Disease: A Prospective Randomized Controlled Trial

Klare¹,

Nigg²,

Nold³

et al. 2015

Digestion

157

130

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Background: Improving health-related quality of life is a primary target of therapy for patients with inflammatory bowel disease. Physical activity has been demonstrated to improve health-related quality of life in several patient populations with chronic disease. There are very few studies investigating the effects of physical activity on health-related quality of life in inflammatory bowel disease. The primary purpose of this study is to investigate the effects of 10 weeks of moderate physical activity on health-related quality of life in patients with inflammatory bowel disease. Methods: Thirty patients with mild to moderate IBD (Crohn‘s Disease Activity Index (CDAI) <220 or Rachmilewitz Index (RI) <11) were randomized 1:1 to either supervised moderate-intensity running thrice a week for 10 weeks or a control group who were not prescribed any exercise. Health-related quality of life, symptoms, and inflammation were assessed at baseline and after 10 weeks. Results: Participants were 41 ± 14 years (73% female), had a body mass index of 22.8 ± 4.1 kg/m², and an average CDAI or RI of 66.8 ± 42.4 and 3.6 ± 3.1. No adverse events occurred during the 10-week training period. Health-related quality of life, reported as IBDQ total score, improved 19% in the intervention group and 8% in the control group. Scores for the IBDQ social sub-scale were significantly improved in the intervention group compared with controls (ΔIBDQ_social = 6.27 ± 5.46 vs. 1.87 ± 4.76, p = 0.023). Conclusion: Patients suffering from moderately active IBD are capable of performing symptom-free regular endurance exercise. Our data support the assumption that PA is feasible in IBD patients. PA may furthermore improve quality of life through improvements in social well-being, and may, therefore, be a useful adjunct to IBD therapy.

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“…Several reasons for the high prevalence of herbal medicine use in this population may include a lack of perceived therapeutic response to standard therapy, increased recognition 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 20 of AEs associated with medication while herbal medicine is generally considered safe or at least not recognised to cause serious side effects, and gaining a sense of control over their disease and management of symptoms [61]. With the increase in IBD patients' use of and researchers' interests in herbal medicine, a number of clinical studies on herbal medicine for IBD have been conducted and accordingly, several systematic reviews and meta-analyses were published [13][14][15].…”

Section: Applicability Of the Evidencementioning

confidence: 99%

Adjunctive herbal medicine therapy for inflammatory bowel disease: A systematic review and meta-analysis

Kim

Lee

Zhang

et al. 2017

European Journal of Integrative Medicine

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Complementary Medicine Use by Patients With Inflammatory Bowel Disease

Abstract: Complementary medicine use is common in patients with IBD, especially among those with a longer duration of disease or a history of hospitalization.

Cited by 103 publications

References 7 publications

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

The Impact of a Ten-Week Physical Exercise Program on Health-Related Quality of Life in Patients with Inflammatory Bowel Disease: A Prospective Randomized Controlled Trial

Adjunctive herbal medicine therapy for inflammatory bowel disease: A systematic review and meta-analysis

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