Complementary light scattering and synchrotron small-angle X-ray scattering studies of the micelle-to-unimer transition of polysulfobetaines

Doncom, Kay E. B.; Pitto-Barry, Anaïs; Willcock, Helen; Lu, Annhelen; McKenzie, Beulah E.; Kirby, Nigel; O’Reilly, Rachel K.

doi:10.1039/c5sm00602c

Cited by 26 publications

(25 citation statements)

References 55 publications

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“…Calibration was achieved with filtered toluene and the background was measured with filtered solvent (NaCl 0.1 M). The hydrodynamic radius, R h , and aggregation number, N agg of the self‐assemblies were calculated using the algorithm method as previously reported . TEM samples were prepared on graphene oxide (GO)‐coated carbon grids, which allows high contrast TEM images to be acquired without staining.…”

Section: Methodsmentioning

confidence: 99%

Amphiphilic block copolymer self‐assemblies of poly(NVP)‐b‐poly(MDO‐co‐vinyl esters): Tunable dimensions and functionalities

Hedir

Pitto-Barry

Dove

et al. 2015

J. Polym. Sci., Part A: Polym. Chem.

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Functional, degradable polymers were synthesized via the copolymerization of vinyl acetate (VAc) and 2-methylene-1,3-dioxepane (MDO) using a macro-xanthate CTA, poly(N-vinylpyrrolidone), resulting in the formation of amphiphilic block copolymers of poly(NVP)-b-poly(MDO-co-VAc). The behavior of the block copolymers in water was investigated and resulted in the formation of self-assembled nanoparticles containing a hydrophobic core and a hydrophilic corona. The size of the resultant nanoparticles was able to be tuned with variation of the hydrophilic and hydrophobic segments of the core and corona by changing the incorporation of the macro-CTA as well as the monomer composition in the copolymers, as observed by Dynamic Light Scattering, Static Light Scattering, and Transmission Electron Microscopy analyses. The concept was further applied to a VAc derivative monomer, vinyl bromobutanoate, to incorporate further functionalities such as fluorescent dithiomaleimide groups throughout the polymer backbone using azidation and "click" chemistry as postpolymerization tools to create fluorescently labeled nanoparticles.

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Section: Methodsmentioning

confidence: 99%

Amphiphilic block copolymer self‐assemblies of poly(NVP)‐b‐poly(MDO‐co‐vinyl esters): Tunable dimensions and functionalities

Hedir

Pitto-Barry

Dove

et al. 2015

J. Polym. Sci., Part A: Polym. Chem.

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“…141−143 In two recent studies N agg data obtained via SLS has been compared to that calculated from SAXS analyses, with good agreement providing greater confidence in the model used for the latter technique. 142,143 …”

Section: Characterization Techniquesmentioning

confidence: 99%

A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self-Assembly

2016

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Recently, polymerization-induced self-assembly (PISA) has become widely recognized as a robust and efficient route to produce block copolymer nanoparticles of controlled size, morphology, and surface chemistry. Several reviews of this field have been published since 2012, but a substantial number of new papers have been published in the last three years. In this Perspective, we provide a critical appraisal of the various advantages offered by this approach, while also pointing out some of its current drawbacks. Promising future research directions as well as remaining technical challenges and unresolved problems are briefly highlighted.

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“…Polymeric nanoparticles comprising block copolymers with cationic, 28,34,[36][37][38] anionic 25,39,40 and zwitterionic 41,42 character have been synthesised via PISA. In both dispersion and emulsion-based PISA systems, it has been shown that the morphology is influenced by the charge density of the solvophilic block -if the charge density is too high, only spheres can form due to the strong repulsive forces between the chains on decreasing the curvature of the interface between the core and the continuous phase.…”

Section: Introductionmentioning

confidence: 99%

Polymerization induced self-assembly: tuning of morphology using ionic strength and pH

et al. 2017

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(2017) Polymerization induced self-assembly : tuning of morphology using ionic strength and pH. Polymer Chemistry, 8 (20). pp. 3082-3089. Permanent WRAP URL:http://wrap.warwick.ac.uk/88640 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work of researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription. Investigations of RAFT dispersion polymerization-induced self-assembly (PISA) of 2-hydroxypropyl methacrylate (HPMA) in water/methanol at 60 o C using a cationically charged macroRAFT agent as stabilizer block, namely P(N,N-diethylaminoethyl methacrylate)-stat-poly((ethylene glycol) methyl ether methacrylate) (PDEAEMA-stat-PEGMA), have been conducted with a view to tune particle morphologies by manipulation of the pH and the ionic strength. Above the LCST (45 °C) of (PDEAEMA-stat-PEGMA), the system can only be conducted as a dispersion polymerization at sufficiently low pH such that the stabilizer block is sufficiently protonated to ensure solubility in the continuous phase. It is demonstrated (reported in the form of an extensive morphology diagram) that a range of morphologies including spherical particles, rods and vesicles can be accessed by adjustment of the pH (via addition of HCl) and the ionic strength (via the concentration of NaCl). A decrease in the charge density of the coronal stabilizer layer via an increase in pH (less protonation) shifts the system towards higher order morphologies. At a given pH, an increase in ionic strength leads to more extensive charge screening, thus allowing formation of higher order morphologies.

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Complementary light scattering and synchrotron small-angle X-ray scattering studies of the micelle-to-unimer transition of polysulfobetaines

Cited by 26 publications

References 55 publications

Amphiphilic block copolymer self‐assemblies of poly(NVP)‐b‐poly(MDO‐co‐vinyl esters): Tunable dimensions and functionalities

Amphiphilic block copolymer self‐assemblies of poly(NVP)‐b‐poly(MDO‐co‐vinyl esters): Tunable dimensions and functionalities

A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self-Assembly

Polymerization induced self-assembly: tuning of morphology using ionic strength and pH

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