Complementary, Holistic, and Integrative Medicine: Therapies for Neurodevelopment in Preterm Infants

Galicia-Connolly, Elaine; Shamseer, Larissa; Vohra, Sunita

doi:10.1542/pir.33-6-276

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…In our study, the cognitive impairments tend be higher in preterm infants subjected to asphyxia or respiratory failure based on the Bayley II assessment. Other studies have shown that there is a reduction in cognitive impairment level from 39% at 20 months to 16% at 8 years, based on the Bayley II assessment in extremely low birth weight infants [39]. The MDI/PDI values for mental and motor scores that were observed at age 2 years in our study could have shown increases at the later stage of development, if these infants had been exposed to early interventions to improve their developmental skills.…”

Section: Discussionsupporting

confidence: 51%

Prediction of delayed neuro-psychomotor development in infants using brainstem auditory evoked potentials and the Bayley II scales

Wang¹,

Carroll

Wang³

et al. 2019

Preprint

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Background: Delayed neuro-psychomotor development in infants tends to be present more often as a result of perinatal issues such as asphyxia, respiratory failure, and prematurity. Brainstem auditory evoked potentials (BAEP) provide an objective analysis of central nervous system function and development in infants. This study proposed to assess the neuro-psychomotor development in infants affected by perinatal conditions by comparing the results of their BAEP with assessments of development including mental development indices (MDI), a form of Bayley Scales of Infant Development. Methods: The retrospectively selected population included preterm (28-36 weeks gestation; 95 cases) and term infants (≥ 37 weeks gestation; 100 cases) who were born with specific perinatal conditions. The BAEP were recorded in these infants from 1 to 8 months of age, and the MDI were performed in these infants at age 2 years. Chi-square, ANOVA, and student t-tests were used to test significance of BAEP correlations with MDI indices in theses infants. Significance was determined at a p-value ≤ 0.05. Results: In premature infants (28-32 weeks gestation), 75% had abnormal BAEP, and MDI at age 2 years were moderately low (90.76 ± 4.1); fewer term infants had abnormal BAEP (24.5%), and MDI at age 2 years were moderately higher (98.55 ± 4.6). Preterm infants with abnormal BAEP, and perinatal asphyxia or respiratory failure had low MDI at age 2 years (76.36 ± 3.66 or 80.36 ± 7.66, respectively); 60% fewer term infants with these perinatal conditions had abnormal BAEP, and their MDI were 3-10% higher. Our results show that infants experiencing prematurity, perinatal asphyxia or respiratory failure, may have lower scores of neuro-psychomotor development at age 2, if earlier tests reveal abnormal BAEP assessments in these infants. Conclusion: Our study found that premature infants exposed at birth to conditions such as asphyxia and respiratory failure, and exhibiting abnormal BAEP in their first year, may be predicted to present with delayed neuro-psychomotor development. We propose that BAEP may be utilized as a potential indicator for neuro-psychomotor development, and suggest that parental education and early intellectual interventions to enrich cognition development in children with abnormal BAEP should be encouraged.

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Section: Discussionsupporting

confidence: 51%

Prediction of delayed neuro-psychomotor development in infants using brainstem auditory evoked potentials and the Bayley II scales

Wang¹,

Carroll

Wang³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…In our study, the cognitive impairments tend be higher in preterm infants subjected to asphyxia or respiratory failure, based on the Bayley II assessment. Other studies have shown that there is a reduction in cognitive impairment level from 39% at 20 months to 16% at 8 years, based on the Bayley II assessment in extremely low birth weight infants (46). In our study, the MDI/PDI values for cognitive and motor scores that were observed at age 2 years might have shown increases at the later stages of development, if these infants had been exposed to early interventions such as cognitive and motor exercises, physical therapy sessions, and learning games with parents to improve their developing cognitive and motor skills.…”

Section: Baep Value Predicts MDI Score In Premature Infantsmentioning

confidence: 96%

Prediction of Delayed Neurodevelopment in Infants Using Brainstem Auditory Evoked Potentials and the Bayley II Scales

et al. 2020

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Background: Brainstem auditory evoked potentials (BAEP) provide an objective analysis of central nervous system function and development in infants. This study proposed to examine the relationship between infant BAEP values at age 6 months, and their neurodevelopment at age 2 years assessed by the mental development indices (MDI), a form of Bayley Scales of Infant Development. We hypothesized that in infants with BAEP values outside normal range, there may be neurodevelopmental delays, as shown by their MDI scores. Methods: An exploratory investigation was conducted using preterm (28-36 weeks gestation; 95 cases) and term infants (≥37 weeks gestation; 100 cases) who were born with specific perinatal conditions. BAEP values were recorded in these infants from 1 to 8 months of age, and compared with MDI scores in these infants at age 2 years. A multivariate linear regressions model was performed to test the associations between all variables and MDI scores. Stratified linear regression was used to test the interactions between gestational age and BAEP values with MDI scores. Significance was determined at a p < 0.05. Results: We found that BAEP values were inversely associated with MDI scores in premature infants (β = −1.89; 95% confidence interval = −3.42 to −0.36), and that the effect of gestational age and BAEP values on the MDI scores is decreased by 1.89 points due to the interaction between these two variables. In premature babies, the lower the BAEP value below the mean, the greater the decrease in MDI score at age 2 years. Asphyxia and lower socioeconomic status in the family were also covariates associated with lower MDI scores at age 2 years. Conclusion: The data provided evidence that BAEP values outside the normal range in premature infants at age 6 months may predict developmental delays in cognitive and motor skills, as shown by MDI scores. We propose that BAEP assessment may be utilized as a potential indicator for neurodevelopment, and suggest that early intellectual Wang et al. Predicting Pediatric Neurodevelopment Using BAEP and public health interventions should be encouraged to enrich neurodevelopment in premature babies with BAEP values outside the normal range.

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Complementary, Holistic, and Integrative Medicine: Therapies for Neurodevelopment in Preterm Infants

Cited by 2 publications

References 13 publications

Prediction of delayed neuro-psychomotor development in infants using brainstem auditory evoked potentials and the Bayley II scales

Prediction of delayed neuro-psychomotor development in infants using brainstem auditory evoked potentials and the Bayley II scales

Prediction of Delayed Neurodevelopment in Infants Using Brainstem Auditory Evoked Potentials and the Bayley II Scales

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