Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

Lopez, Marc; Eberlé, Frédéric; Matteï, Marie‐Geneviève; Gabert, Jean; Birg, Françoise; Bardin, Florence; Maroc, Christine; Dubreuil, Patrice

doi:10.1016/0378-1119(94)00842-g

Cited by 149 publications

(142 citation statements)

References 16 publications

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“…The most significant matches are with Tactile, a T cell activation antigen (37), the BGP-1 or CD66 (38), a polio virus receptor related protein, PRR (39), and Neuroglian (40).…”

Section: Resultsmentioning

confidence: 99%

TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression

Sherrington¹,

Scott²,

Jin³

et al. 1997

Journal of Biological Chemistry

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T lineage-specific activation antigen 1 (TLiSA1) antigen was initially described as a T lineage-specific activation antigen involved in the differentiation of human cytotoxic T cells. Subsequently, the antigen was identified on platelets and was shown to be involved in platelet activation, hence it was renamed platelet and T cell antigen 1 (PTA1), although identity between the two antigens was not established. In the present study we have cloned the cDNA encoding TLiSA1 from Jurkat cells and show it to be a novel member of the immunoglobulin superfamily with the unusual structure of two V domains only. Identity between TLiSA1 and platelet PTA1 is established by immunological criteria, by internal peptide sequences obtained from the purified platelet glycoprotein and by sequencing the platelet transcript after reverse transcriptase-polymerase chain reaction. In Jurkat cells, TLiSA1/PTA1 mRNA and surface protein expression is greatly stimulated by treatment of the cells with phorbol ester, but the T cell proliferative signal of phorbol ester and ionophore combined greatly reduces or abrogates this response, and this suppressive effect of the ionophore is not reversed by incorporating FK506 to inhibit calcineurin. Together with the known signaling role of PTA1, these data substantiate the notion that this molecule is implicated in T cell differentiation, perhaps by engagement of an adhesive ligand.

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“…The most significant matches are with Tactile, a T cell activation antigen (37), the BGP-1 or CD66 (38), a polio virus receptor related protein, PRR (39), and Neuroglian (40).…”

Section: Resultsmentioning

confidence: 99%

TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression

Sherrington¹,

Scott²,

Jin³

et al. 1997

Journal of Biological Chemistry

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“…Samples were pre-blocked with goat serum to reduce nonspecific staining. Unfractionated or CD34-sorted Ficoll-purified bone marrow cells were stained for CD155 using MA38 (kindly provided from M Lopez 37 ), a secondary goat anti-mouse Ig-FITC (immunoglobulin-fluorescein isothiocyanate; Sigma, St Louis, MO, USA) antibody and CD34-PE (CD34-phycoerythrin; BectonDickinson, Franklin Lakes, NJ, USA) as described. 19 Cells were analyzed using FACSCalibur (BD Bioscience, San Jose, CA, USA).…”

Section: Stainingmentioning

confidence: 99%

CD34+ hematopoietic stem cells support entry and replication of poliovirus: a potential new gene introduction route

et al. 2013

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Pluripotent hematopoietic stem cells (HSC) are critical in sustaining and constantly renewing the blood and immune system. The ability to alter biological characteristics of HSC by introducing and expressing genes would have enormous therapeutic possibilities. Previous unpublished work suggested that human HSC co-express CD34 (cluster of differentiation 34; an HSC marker) and CD155 (poliovirus receptor; also called Necl-5/Tage4/PVR/CD155). In the present study, we demonstrate the co-expression of CD34 and CD155 in primary human HSC. In addition, we demonstrate that poliovirus infects and replicates in human hematopoietic progenitor cell lines. Finally, we show that poliovirus replicates in CD34 þ enriched primary HSC. CD34 þ enriched HSC co-express CD155 and support poliovirus replication. These data may help further understanding of poliovirus spread in vivo and also demonstrate that human HSC may be amenable for gene therapy via poliovirus-capsid-based vectors. They may also help elucidate the normal function of Necl-5/Tage4/PVR/CD155.

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“…We performed cosegregation and homozygosity analysis with microsatellite markers corresponding to candidate genes involved in the related phenotype. These included MSX1 (MIM 142983) at 4p16.1-p16.3 (D4S412, D4S2925, D4S2935, D4S2285) (Ivens et al 1990), MSX2 (MIM 123101) at 5q34-q35 (D5S529, D5S2050, D5S625, D5S2108) (Jabs et al 1993), epidermal growth factor (EGF, MIM 131530) at 4q25-27 (D4S1564, D4S193, D4S1611, D4S402) (Morton et al 1986), epidermal growth factor receptor (EGFR, MIM 131550) at 7p12.1-p12.3 (D7S2561, D7S674, D7S506, D7S2475) (Haley et al 1987), ectodermal dysplasia type 1 (ED1, MIM 305100) (MIM 300451) at Xq12-q13.1 (DXS7132, DXS1216, DXS8031, DXS453) (Srivastava et al 1996), ectodermal dysplasia type 2 (ED2, MIM 129500) gene GJB6 (MIM 604418) at 13q12.11-q12.3 (D13S1316, D13S175, D13S633, D13S250, D13S787) (Kelley et al 1999), ectodermal dysplasia type 3 (ED3, MIM 224900), ectodysplasin1 anhidrotic receptor (EDAR, MIM 604095) at 2q11-q13 (D2S1343, D2S2954, D2S340, D2S1889, D2S1893, D2S1891) (Monreal et al 1999), and ectodermal dysplasia type 4 (ED4, MIM 225000) PVRL1 (MIM 600644) at 11q23-q24 (D11S1885, D11S4171, D11S4129, D11S924, D11S1299) (Lopez et al 1995).…”

Section: Clinical Findingsmentioning

confidence: 99%

A novel missense mutation in MSX1 underlies autosomal recessive oligodontia with associated dental anomalies in Pakistani families

et al. 2006

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Tooth agenesis constitutes the most common anomaly of dental development in humans. In the majority of familial cases of hypodontia alone or in association with other anomalies, the mode of inheritance is autosomal dominant. In the present study, we have identified two distantly related consanguineous Pakistani kindreds with an autosomal recessive form of oligodontia with associated dental anomalies. Locus in this case has been mapped on chromosome 4p16.1-p16.3. The maximum two-point LOD score of 2.85 (h=0.0) was obtained at markers D4S2925 and D4S2285. A maximum multipoint LOD score exceeding 4 was obtained at the same markers. Recombination events observed in affected individuals localized the disease locus between markers D4S412 and D4S2935, spanning a 9.24-cM region on chromosome 4p16.1-p16.3. Sequence analysis of candidate gene MSX1 revealed a novel recessive missense mutation resulting in substitution of alanine to threonine amino acid (p. A219T), located in the MSX1 homeodomain, which is important for DNA binding and proteinprotein interaction. The mutation, p. A219T, is the first recessive mutation identified in MSX1.

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Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

Cited by 149 publications

References 16 publications

TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression

TLiSA1 (PTA1) Activation Antigen Implicated in T Cell Differentiation and Platelet Activation Is a Member of the Immunoglobulin Superfamily Exhibiting Distinctive Regulation of Expression

CD34+ hematopoietic stem cells support entry and replication of poliovirus: a potential new gene introduction route

A novel missense mutation in MSX1 underlies autosomal recessive oligodontia with associated dental anomalies in Pakistani families

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