Abstract"ttention-deficit/hyperactivity disorder "DHD is the most common neurodevelopmental disorder of childhood characterized by the three core symptoms of hyperactivity, impulsiveness, and sustained inattention. While the etiology of "DHD remains unknown, several studies suggest "DHD pathophysiology to involve frontal network abnormality and dysregulation of catecholaminergic and dopaminergic functions. Stimulants, which are structurally similar to endogenous catecholamines, are the most commonly prescribed drugs for treatment of "DHD, but are classified as Schedule II based on the Controlled Substances "ct due to high likelihood for diversion and abuse. Non-stimulant medications, as well as antidepressants, have also been used in "DHD treatment but have been found to be inferior to stimulant interventions and to cause intolerable side effects. The search for safer yet effective "DHD treatments led to a growing interest in natural medicines and a host of other complementary and alternative treatments for "DHD. While the use of these therapies is well documented, not much is known about their safety and efficacy. In this chapter, we describe current evidence-based complementary and alternative therapies for "DHD, focusing on nutritional and botanical agents, and provide details on the performance of these agents in clinical trials. Here, we discuss the rationale for the use of natural products for "DHD, mention the potential mechanisms of action of these treatments, and highlight safety and efficacy issues associated with the use of these treatments. In conclusion, we give an exhaustive update on the use of nutritional and botanical medicines as complementary and alternative "DHD therapies for "DHD, which