Complementary and Alternative Therapies for the Management of Dyslipidemia

Nies, Leslie K; Cymbala, Alicia A; Kasten, Sheila L.; Lamprecht, Donald G.; Olson, Kari L.

doi:10.1345/aph.1h040

Cited by 32 publications

(21 citation statements)

References 76 publications

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“…This seed, when used as a dietary supplement, has been shown to be beneficial in some pathological processes, as described in previous experimental studies (Hansen, 2006;Nies, Cymbala, Kasten, Lamprecht, & Olson, 2006;Paschos, Magkos, Panagiotakos, Votteas, & Zampelas, 2007;Sekine, Sasanuki, Murano, Aoyama, & Takeuchi, 2008). Flaxseed is a rich source of polyunsaturated fatty acids (PUFAS) and contains an average of 41% oil.…”

Section: Introductionmentioning

confidence: 90%

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

Daleprane

Batista

Pacheco

et al. 2010

Food Research International

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The aim of this study was to evaluate the influence of flaxseed diet supplementation on endothelial function in the mesenteric arterial bed of rats. Twenty-four rats were divided into 3 groups: Control Group (CG; 10% protein; 5% fiber; 7% lipid); Flaxseed Group (FG, supplemented with 25% flaxseed; 10% protein; 7% fiber; 11% lipid); and Modified Control Group (MCG; 10% protein; 7% fiber; 11% lipid). The blood was obtained by cardiac puncture (after 180 days) and the serum was separated for lipid profile analyses. The vasodilator effect of acetylcholine (1-100 pmol) was evaluated in the preconstricted isolated rat vascular bed. FG showed a 47% increase in HDL-C, a 22% reduction in LDL-C, a 23% reduction in triacylglycerols, and an increased (p b 0.05) vasodilator response to acetylcholine, in relation to the CG and CMG groups. These results suggest that flaxseed has a cardioprotective effect by improving the blood lipid profile and endothelial function.

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Section: Introductionmentioning

confidence: 90%

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

Daleprane

Batista

Pacheco

et al. 2010

Food Research International

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“…The dietary management of dyslipidemia has been shown to be effective, and numerous dietary approaches are becoming popular in the management of hypercholesterolemia [7]. One advantage of dietary management is the lack of drug-induced side effects.…”

Section: Introductionmentioning

confidence: 99%

The Hypocholesterolemic Effect of Germinated Brown Rice Involves the Upregulation of the Apolipoprotein A1 and Low-Density Lipoprotein Receptor Genes

Imam

Ismail

Omar

et al. 2013

Journal of Diabetes Research

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Germinated brown rice (GBR) is rich in bioactive compounds, which confer GBR with many functional properties. Evidence of its hypocholesterolemic effects is emerging, but the exact mechanisms of action and bioactive compounds involved have not been fully documented. Using type 2 diabetic rats, we studied the effects of white rice, GBR, and brown rice (BR) on lipid profile and on the regulation of selected genes involved in cholesterol metabolism. Our results showed that the upregulation of apolipoprotein A1 and low-density lipoprotein receptor genes was involved in the hypocholesterolemic effects of GBR. Additionally, in vitro studies using HEPG2 cells showed that acylated steryl glycoside, gamma amino butyric acid, and oryzanol and phenolic extracts of GBR contribute to the nutrigenomic regulation of these genes. Transcriptional and nontranscriptional mechanisms are likely involved in the overall hypocholesterolemic effects of GBR suggesting that it may have an impact on the prevention and/or management of hypercholesterolemia due to a wide variety of metabolic perturbations. However, there is need to conduct long-term clinical trials to determine the clinical relevance of the hypocholesterolemic effects of GBR determined through animal studies.

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“…There is evidence suggesting that fatty alcohols modulate the serum cholesterol concentration in human subjects [1]. In various human studies, a daily supplement of 5-20 mg policosanol decreased the LDL cholesterol concentration between 19 and 31% and the total cholesterol (TC) concentration between 13 and 23%.…”

Section: Introductionmentioning

confidence: 99%

Octacosanol Administration to Humans Decreases Neutral Sterol and Bile Acid Concentration in Feces

Keller

Gimmler

Jahreis

2007

Lipids

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To investigate octacosanol (OC) metabolism in humans and its influence on cholesterol metabolism, two studies were conducted. In the first study ten healthy women received daily 30 mg OC for a period of 4 weeks. Blood and feces samples were collected at baseline and after the intervention. Serum concentrations of total cholesterol, LDL cholesterol, and HDL cholesterol were not altered following OC administration. Concentrations of excreted cholesterol end products decreased with the intervention (neutral sterols: 24.6 +/- 9.7 mg/g vs. 20.3 +/- 7.5 mg/g dry matter, P < 0.05; bile acids: 6.47 +/- 3.89 mg/g vs. 4.03 +/- 2.26 mg/g dry matter, P < 0.05). OC was not detected in serum samples, but the fecal OC concentration increased after the intervention period (11 +/- 7 microg/g vs. 817 +/- 179 microg/g dry matter, P < 0.05). In the second kinetic study on three participants, OC was identified in serums after oral application of 50 mg OC within 8 h. The decrease in the concentration of fecal cholesterol end products may underline a systemic effect of OC on cholesterol metabolism, even though the serum cholesterol levels were not influenced.

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Complementary and Alternative Therapies for the Management of Dyslipidemia

Abstract: Alternative therapeutic approaches with complementary therapies are becoming increasingly popular among patients. It is important for healthcare providers to be familiar with the safety and efficacy of these agents to facilitate optimal outcomes for patients with dyslipidemia.

Cited by 32 publications

References 76 publications

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

The Hypocholesterolemic Effect of Germinated Brown Rice Involves the Upregulation of the Apolipoprotein A1 and Low-Density Lipoprotein Receptor Genes

Octacosanol Administration to Humans Decreases Neutral Sterol and Bile Acid Concentration in Feces

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