Complementary administration of curcumin in PCOS: a systematic review

Venkatesan, Kirthika; Menon, Sukrita; Firoz, Irene N; Narendrula, Rashmi; Kunnath, Jafrikh T; Kalapurakal, Ann M; Haroon, Nisha Nigil; Iqbal, Anoop M; Ashok, Anuja

doi:10.23736/s2724-606x.22.05129-6

Cited by 1 publication

(2 citation statements)

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“…Curcumin, a biologically active polyphenolic compound found in turmeric, supplementation was examined by three RCTs and was found to be effective in reducing weight, BMI, fasting glucose, serum insulin, total cholesterol, and LDL-cholesterol [24][25][26]. Our findings mirror those found in the review by Venkatesan et al, 2022, which demonstrated that supplementation of curcumin alone in the diets of PCOS patients resulted in improved glycemic and lipid profiles as well as reduced BMI [44]. Curcumin has been demonstrated to activate various insulin receptors as well as inhibit the production of numerous proinflammatory cytokines that are responsible for the pathogenesis of metabolic disorders [45], specifically in type 2 diabetes.…”

Section: Phytochemical-based Supplements and Pcossupporting

confidence: 84%

“…The insulin resistance in PCOS has a similar pathogenesis to that in type 2 diabetes; thus, curcumin likely exerts similar effects in the insulin resistance pathway in PCOS patients. Furthermore, Venkatesan et al's review was able to demonstrate a significant improvement in circulating androgen levels associated with PCOS [44]. It has been documented that the excessive androgens present in PCOS result in endoplasmic reticulum stress in ovarian granulosa cells, resulting in proliferation of follicles via the phosphatidylinositol-3-kinase (PI3K/AKT) pathway and ultimate formation of the ovarian cysts seen in PCOS [46].…”

Section: Phytochemical-based Supplements and Pcosmentioning

confidence: 99%

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The Effects of Plant-Derived Phytochemical Compounds and Phytochemical-Rich Diets on Females with Polycystic Ovarian Syndrome: A Scoping Review of Clinical Trials

Chávez

Jaworsky

Basu

2023

IJERPH

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Polycystic ovarian syndrome (PCOS) is an endocrine condition that impacts nutritional status, metabolic, and hormonal function in females of reproductive age. This condition is associated with increased androgen production (hyperandrogenism) and decreased insulin sensitivity, which often leads to insulin resistance and hyperinsulinemia. This increase in androgen production and insulin resistance is strongly associated with a high incidence of obesity, type-2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and certain types of gonad-related cancers among females who suffer from this condition. As research continues to grow, it has been demonstrated that PCOS is a complex condition, and some of its characteristics vary among the females that have this disorder. However, it has been suggested that oxidative stress and low-grade chronic inflammation could play an important role in the development of PCOS. Current evidence suggest that phytochemicals could potentially help with weight-loss by reducing oxidative stress and low-grade inflammation, as well as aid in metabolic and hormonal regulation due to their antioxidant properties. Some of the bioactive compounds found in plants that have shown positive effects in the attenuation of PCOS include flavonoids, polyphenols, phytoestrogen, and polyunsaturated fatty acids (PUFAs). Thus, a review of the current literature published on PCOS and phytochemicals was conducted in PubMed, Google Scholar, and the Academy of Nutrition and Dietetics databases for articles published between 2013 and 2023 with a study duration of 1 to 3 months and adequate sample sizes. The main purpose of this review of literature was to investigate the metabolic effects of phytochemical compounds and phytochemical-rich diets on females with PCOS by comparing the results of several randomized clinical trials.

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