“…In our work, we saw reductions in hippocampal expression of C1q and C3 following mIA, across sexes, and also with protein levels of C1q, in neurons. These reductions could reflect a decrease in complement-mediated synaptic elimination (Stevens et al, 2007;Druart and Le Magueresse, 2019;Sellgren et al, 2019;Magdalon et al, 2020;Tenner, 2020). However, unlike the gene expression, C3 protein levels are increased with mIA across both sexes.…”