Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis

Vandendriessche, Sofie; Cambier, Seppe; Proost, Paul; Marques, Pedro Elias

doi:10.3389/fcell.2021.624025

Cited by 79 publications

(69 citation statements)

References 294 publications

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“…These mechanism might contribute to our understanding of how disordered proteins or cell debris generated by aggressive inflammatory environments are cleared and how build-up of pathological protein aggregates are avoided ( 19 ). Finally, being a highly conserved protein sharing structural similarities with complement factors C3 and C4 ( 23 ), it is interesting to see how some of the functions of A2M might relate to functions of the complement system such as opsonization and complement-mediated phagocytosis ( 190 ).…”

Section: Discussionmentioning

confidence: 99%

Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

2021

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Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for endopeptidases of all catalytic types, alpha-2-macroglobulin lures active proteases into its molecular cage and subsequently ‘flags’ their complex for elimination. In addition to its role as a regulator of extracellular proteolysis, alpha-2-macroglobulin also has other functions such as switching proteolysis towards small substrates, facilitating cell migration and the binding of cytokines, growth factors and damaged extracellular proteins. These functions appear particularly important in the context of immune-cell function. In this review manuscript, we provide an overview of all functions of alpha-2-macroglobulin and place these in the context of inflammation, immunity and infections.

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Section: Discussionmentioning

confidence: 99%

Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

2021

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“…Furthermore, CD11b is also part of the complement receptor 3, and plays as such a role in phagocytosis for complement-opsonized pathogens [58]. Thus, CD11b-negative cells are likely to be impaired in this pathway, and thus efficient for the elimination of pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we also tested CD11b, a cell-surface marker important for the good functioning of macrophages. Indeed, CD11b is also part of the complement receptor 3, and, as such, plays a role in phagocytosis for complement-opsonized pathogens [57]. Thus, CD11b-negative cells are likely to be impaired, and thus, less efficient for the elimination of pathogens.…”

Section: Discussionmentioning

confidence: 99%

Immediate and sustained effects of cobalt and zinc-containing pigments on macrophages

Devcic

Dalzon

et al. 2021

Preprint

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Tattoos are trending, and in the USA 25% of people aged 18 to 50 are tattooed. The more people get tattoos, the more skin injuries are discovered and reported in the literature. The short-term and localized effects are well known, but injection of tattoo inks can be associated to long-term risks. In this article, we investigated three cobalt pigments, which constitute a wide range of colors found in tattoos: Pigment Violet 14 (purple), Pigment Green19 (green), and Pigment Blue 28 (blue). After injection, macrophages are among the first cells to come in contact with pigments. We thus tested the effects of cobalt-based pigments on the macrophage cell line J774A1. In order to detect delayed effects, we compared two exposure schemes: acute exposure for 24 hours and with a 3 days post-exposure recovery period. The conjunction of these two schemes allowed the investigation of delayed or sustained effects of the pigments. Pigment dissolution and cobalt release was very variable from one pigment to another, Pigment Violet 14 and Pigment Green19 being easily dissolved, while Pigment Blue 28 dissolved much more slowly. The cytotoxicity of the pigments correlated well with their dissolution. All pigments induced functional effects on macrophages, which were largely pigment-dependent. For example, Pigment Green19 and Pigment Blue 28 showed a delayed effect on the phagocytic capacity of the cells. All three pigments induced a low but significant secretion of tumor necrosis factor, but the effect was transient. Conversely, Pigment Violet 14 and Pigment Blue 28 induced a sustained secretion of interleukin 6, although at low levels. The pigments also induced changes in some important membrane markers of macrophages such as CD11b, PdL-1 or CD206. In conclusion, the pigments induced functional perturbations in macrophages, sometimes persistent over time after exposure, even at non-toxic doses.

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“…In bony fishes, the phagocytic armament includes macrophages, monocytes, dendritic cells, neutrophils, granulocytes, eosinophils, basophils and mast cells [18]. While in mammals, these professional phagocytes are able to differentiate into highly specialized subtypes of cells which exert different cytokine profiles, exclusive functions in regeneration and infection fighting (i.e., M1 and M2 macrophages), tissue specificity and also novel molecular mechanisms such as the antibody-dependent cellular phagocytosis (ADCP) for the clearance of microorganisms and immune complexes [19,20].…”

Section: Phagocytic Effector Cellsmentioning

confidence: 99%

Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages

Mandujano-Tinoco

Sultan

Ottolenghi

et al. 2021

Cells

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The immune system has evolved to protect organisms from infections caused by bacteria, viruses, and parasitic pathogens. In addition, it provides regenerative capacities, tissue maintenance, and self/non-self recognition of foreign tissues. Phagocytosis and cytotoxicity are two prominent cellular immune activities positioned at the base of immune effector function in mammals. Although these immune mechanisms have diversified into a wide heterogeneous repertoire of effector cells, it appears that they share some common cellular and molecular features in all animals, but also some interesting convergent mechanisms. In this review, we will explore the current knowledge about the evolution of phagocytic and cytotoxic immune lineages against pathogens, in the clearance of damaged cells, for regeneration, for histocompatibility recognition, and in killing virally infected cells. To this end, we give different immune examples of multicellular organism models, ranging from the roots of bilateral organisms to chordate invertebrates, comparing to vertebrates’ lineages. In this review, we compare cellular lineage homologies at the cellular and molecular levels. We aim to highlight and discuss the diverse function plasticity within the evolved immune effector cells, and even suggest the costs and benefits that it may imply for organisms with the meaning of greater defense against pathogens but less ability to regenerate damaged tissues and organs.

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Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis

Cited by 79 publications

References 294 publications

Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

Immediate and sustained effects of cobalt and zinc-containing pigments on macrophages

Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages

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