Complement receptor type 1 (CR1) deficiency on neutrophils in myelodysplastic syndrome

Ohsaka, Akimichi; Saionji, Katsu; Watanabe, Norimichi; Yokomichi, Hiroshi; Sugahara, Yuichi; Nagayama, Reizo; Igari, J

doi:10.1111/j.1365-2141.1994.tb05042.x

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…The NAP activity level has no significant correlation to the MPO activity level (7), as confirmed in the current report. A literature review found only two cases of MDS with extremely low NAP activity comparable to the present cases (8,9). The case reported by Ohsaka et al (8) involved absent levels of NAP as well as absent levels of complement receptor type 1, while the expressions of of other complement receptors, Fc receptors and adhesion molecules were normal.…”

Section: Discussionsupporting

confidence: 58%

“…A literature review found only two cases of MDS with extremely low NAP activity comparable to the present cases (8,9). The case reported by Ohsaka et al (8) involved absent levels of NAP as well as absent levels of complement receptor type 1, while the expressions of of other complement receptors, Fc receptors and adhesion molecules were normal. In our series, a flow cytometric evaluation of the PB neutrophils showed no consistent abnormalities in neutrophil cell surface markers, except for a somewhat reduced expression of the Fc γ receptor (CD64) and the G-CSF receptor (CD114) in Case 1 (Table).…”

Section: Discussionsupporting

confidence: 58%

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Absent or Extremely Low Neutrophil Alkaline Phosphatase Activity Levels in Patients with Myelodysplastic Syndromes

et al. 2013

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Three patients with myelodysplastic syndrome (MDS) had absent or extremely low levels of neutrophil alkaline phosphatase (NAP) activity (arbitrarily defined as an NAP score <10). All patients showed varying degrees of hypogranulation in neutrophil morphology. The NAP activity levels transiently normalized following the administration of granulocyte colony-stimulating factor (G-CSF) in two cases. No patients experienced any severe infectious episodes. These results suggest that NAP activity is not central to the neutrophil function.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionsupporting

confidence: 58%

Absent or Extremely Low Neutrophil Alkaline Phosphatase Activity Levels in Patients with Myelodysplastic Syndromes

et al. 2013

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“…¹ release and CR expression on neutrophils are impaired in some MDS patients (Ohsaka et al, 1993a(Ohsaka et al, , 1994. The impairment of adhesion-dependent neutrophil functions may be related to the decreased expression of CD11b/CD18 on MDS neutrophils (Mazzone et al, 1993).…”

Section: Omentioning

confidence: 99%

“…Neutrophil membrane antigens are abnormal with the persistence of an immature myeloid antigen in MDS patients (Baumann et al, 1986). Our previous studies indicated that neutrophil functions, such as superoxide (O 2 ¹ ) release and complement receptor expression, are impaired in some MDS patients (Ohsaka et al, 1993a(Ohsaka et al, , 1994. We also reported that granulocyte colony-stimulating factor (G-CSF) enhances O 2 ¹ release in neutrophils from MDS patients both in vitro and in vivo (Ohsaka et al, 1993a), suggesting that G-CSF administration has merit for enhancing host defence against microorganisms in MDS patients as well as in other haematological disorders (Ohsaka et al, 1989(Ohsaka et al, , 1992(Ohsaka et al, , 1996.…”

mentioning

confidence: 99%

Altered surface expression of effector cell molecules on neutrophils in myelodysplastic syndromes

et al. 1997

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Summary. The surface expression of effector cell molecules on neutrophils was examined in 18 patients with myelodysplastic syndromes (MDS) and 20 healthy control subjects. The MDS patients were further classified as low clinical risk (L-MDS, n ¼ 7) and high clinical risk (H-MDS, n ¼ 11). The expression of Fc receptors for IgG (FcR), complement receptors (CR) and cellular adhesion molecules on neutrophils was determined by flow cytometry and monoclonal antibodies. The effect of granulocyte colony-stimulating factor (G-CSF) and tumour necrosis factor-alpha (TNF) on L-selectin shedding and CR up-regulation on neutrophils was also examined. The percentage of FcRI-positive neutrophils and CD11b/CR3 expression on neutrophils were significantly increased in the H-MDS patients when compared to the controls. In contrast, the expression of FcRII, FcRIII, L-selectin, LFA-1 and CD18 on neutrophils was significantly reduced in the H-MDS patients compared with the controls. The L-MDS neutrophils exhibited lower expressions of CR1, L-selectin, LFA-1 and CD18 than those of the controls. Neutrophils from some H-MDS patients showed impaired L-selectin shedding and CR up-regulation after stimulation with G-CSF or TNF, although these were not significantly different when assessed in the whole H-MDS group. These findings suggest that an altered surface expression of effector cell molecules and an impaired modulation of cellular adhesion molecules on neutrophils may contribute to the increased susceptibility to bacterial infections in MDS patients.

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“…Decreased CD10 expression has been associated with increased susceptibility to infections, likely due to its role in neutrophil chemotaxis and coordination of the inflammatory response 22. This becomes clinically evident amongst neonates, patients with burns and those with systemic sepsis, all of which have been shown to have both reduced CD10 expression on their granulocytes, and a degree of immunosuppression 6.…”

Section: Discussionmentioning

confidence: 99%

Decreased Cd10 Expression in the Bone Marrow Neutrophils of Hiv Positive Patients

Vyver

Visser

2010

Mediterr J Hematol Infect Dis

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Background:HIV-1 infection is associated with various quantitative and qualitative changes in haemopoietic cells. Clear distinction between primary myelodysplastic syndrome (MDS) and secondary dysplasia may not always be possible. Adjunctive analyses used in the diagnosis of MDS include cytogenetics and flow cytometry (FCM). Much focus has been placed on establishing FCM guidelines aiding in the diagnosis of MDS, and to distinguish this condition from secondary dysplastic changes. One of the parameters often cited is the CD10 expression on the granulocyte population, as this marker denotes granulocytic maturation.Aims:To determine the expression level of CD10 on granulocytes in HIV positive patients.Methods:In total, 117 HIV-1 positive and 29 HIV-1 negative patients were included in this study. Bone marrow aspirate samples were evaluated in terms of morphological abnormality as well as CD10 expression on the granulocytic population.Results:The average CD10 expression among the HIV-1 positive patients were markedly reduced, at 18.4%, and 113 patients (96.6%) of these patients had expression levels below 50%.Discussion:Disease conditions causing secondary dysplasia, especially HIV-1 infection, is associated with a marked reduction in CD10 expression on the granulocyte population independent from the presence of myelodysplastic features. This marker is therefore of doubtful significance as a diagnostic tool in distinguishing between primary and secondary dysplasia.

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Complement receptor type 1 (CR1) deficiency on neutrophils in myelodysplastic syndrome

Cited by 7 publications

References 10 publications

Absent or Extremely Low Neutrophil Alkaline Phosphatase Activity Levels in Patients with Myelodysplastic Syndromes

Absent or Extremely Low Neutrophil Alkaline Phosphatase Activity Levels in Patients with Myelodysplastic Syndromes

Altered surface expression of effector cell molecules on neutrophils in myelodysplastic syndromes

Decreased Cd10 Expression in the Bone Marrow Neutrophils of Hiv Positive Patients

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