Complement Inhibiting Properties of Dragon’s Blood from Croton draco

Tsacheva, Ivanka; Rostan, Joerg; Iossifova, Tanya; Vogler, Bernhard; Odjakova, Mariela; Navas, Hernan; Kostova, I.; Kojouharova, Michaela; Kraus, Wolfgang

doi:10.1515/znc-2004-7-814

Cited by 17 publications

(21 citation statements)

References 2 publications

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“…Taspine (14), an unusual alkaloid with a dilactone structure resembling elagic acid and one nitrogen atom not included in a heterocyclic ring, was found in the red latex of three species, C. draco, 33,108 C. lechleri 9,109 and C. palanostigma. 110 Taspine has been obtained also from plant sources of benzylisoquinolines and biogenetically related alkaloids, such as Berberidaceae and Magnoliaceae.…”

Section: Alkaloidsmentioning

confidence: 99%

“…From the red latex of C. draco 108 and C. panamensis 126 myricitrin (myricetin-3-O-rhamnoside) was isolated. Leaves of C. cajucara yielded kaempferol-3,7-dimethyl ether and 3,4',7-trimethyl ether, 50 while shoots of C. schiedeanus contain quercetin-3,7-dimethyl ether.…”

Section: Flavonoids and Other Phenolic Substancesmentioning

confidence: 99%

“…The red latex of C. draco and its ethyl acetate and ethyl ether extracts exhibited high inhibition on the classical activation pathway of the complement system using hemolytic assay. 108 …”

Section: Immunomodulatory Antibacterial Antifungal and Antiviralmentioning

confidence: 99%

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Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

394

320

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Croton é um gênero de Euphorbiaceae com cerca de 1300 espécies, amplamente distribuídas em regiões tropicais do Novo e Velho Mundos. Várias espécies há muito tempo desempenham papel importante nos usos tradicionais de plantas medicinais na África, Ásia e América do Sul. Tais usos incluem tratamento de câncer, constipação intestinal, diarréia e outros problemas digestivos, diabetes, feridas externas, febre, hipercolesterolemia, hipertensão, inflamação, vermes intestinais, malária, dor, úlceras e obesidade. Várias espécies de Croton têm um látex vermelho que contém, em algumas espécies, pró-antocianidinas e/ou alcalóides. Os alcalóides de Croton são a taspina ou substâncias relacionadas a benzilisoquinolinas. Os diterpenos são muito comuns em Croton, correspondendo a clerodanos, cembranóides, halimanos, cauranos, labdanos, ésteres do forbol, traquilobanos e sarcopetalanos. Algumas espécies são aromáticas, devido à presença de óleos voláteis. Representantes de novas classes de substâncias (fenilbutanóides, alcalóides glutarimidínicos e diterpenos sarcopetalanos) têm sido isoladas de espécies de Croton. Enquanto laticíferos têm sido descritos em espécies de Croton, até o momento não há estudos anatômicos sobre estruturas secretoras de óleos voláteis. Parece haver afinidades químicas no gênero relacionadas à geografia, agrupando espécies com (i) cauranos e/ou labdanos, (ii) traquilobanos e (iii) alcalóides. Os ensaios farmacológicos freqüentemente vêm corroborando os usos tradicionais de espécies de Croton. Grande parte dos ensaios farmacológicos trata do clerodano trans-desidrocrotonina, envolvendo uma grande diversidade de efeitos, incluindo hipolipidêmico, hipoglicêmico, antiestrogênico e anticâncer. Efeitos citotóxicos também vêm sendo observados em ensaios com alcalóides (taspina) e com diterpenóides secocaurenos, labdanos e cembranóides. Vários outros efeitos de substâncias de Croton têm sido relatados, incluindo anti-hipertensivos, antiinflamatórios, antimaláricos, antimicrobianos, antiespasmódicos, antiulcerogênicos, antivirais e mio-relaxantes.Croton is a genus of Euphorbiaceae comprising around 1,300 species, widespread in tropical regions of the Old and New Worlds. Several species have a long role in the traditional use of medicinal plants in Africa, Asia and South America. Popular uses include treatment of cancer, constipation, diabetes, digestive problems, dysentery, external wounds, fever, hypercholesterolemia, hypertension, inflammation, intestinal worms, malaria, pain, ulcers and weight-loss. Several species of Croton have a red sap, in some species containing proanthocyanidins and/or alkaloids. The latter may be taspine or some of several benzylisoquinoline-like compounds. Diterpenes are very common in Croton, corresponding to clerodanes, cembranoid, halimanes, kauranes, labdanes, phorbol esters, trachylobanes and sarcopetalanes. Some species are aromatic due to the possession of volatile oils. Representatives of new classes of compounds (phenylbutanoids, glutarimide alkaloids, sarcopetalane diterpen...

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Section: Alkaloidsmentioning

confidence: 99%

Section: Flavonoids and Other Phenolic Substancesmentioning

confidence: 99%

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Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Salatino¹,

Salatino²,

Negri³

2007

J. Braz. Chem. Soc.

394

320

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“…In addition, it was also isolated in the leaves Eugenia L. (Myrtaceae; Schmeda-Hirschmannet et al, 1987) and in the latex of Croton draco Schltdl. (Euphorbiaceae; Tsacheva et al, 1987).…”

Section: Flavonoidsmentioning

confidence: 99%

Chemotaxonomic significance of flavonoids, coumarins and triterpenes of Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, with new insights about its systematic position within the family

Choze¹,

Delprete²,

Lião³

2010

Rev. bras. farmacogn.

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RESUMO: "Significância quimiotaxômica de flavonoides, cumarinas e triterpenos de Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, com novos entendimentos sobre a posição sistemática dentro da família". Augusta tem sido tradicionalmente colocada na tribo Rondeletieae, Cinchonoideae subfamília. No entanto, recentes filogenias moleculares posicionou-a perto de Wendlandia, porém localizando A. longifolia perto do clado Ixoroidinae II. O estudo de A. longifolia resultou em duas cumarinas, cinco flavonoides, três triterpenoides e um derivado do ácido benzóico. Estes metabolitos reforçam a separação da Augusta como um gênero monoespecífico, e Lindenia como um gênero de três espécies, intimamente relacionada com Wendlandia.Unitermos: Rubiaceae, Augusta, Wendlandia, Lindenia, quimiotaxonomia.ABSTRACT: Augusta has traditionally been placed in the tribe Rondeletieae, subfamily Cinchonoideae. However, recent molecular phylogenies positioned it near to Wendlandia (Ixoroideae), but locate A. longifolia near to the clade Ixoroidinae II. The study of A. longifolia afforded two coumarins, five flavonoids, three triterpenoids and one benzoic acid derivative. These metabolites reinforce the separation of Augusta as a monospecific genus, and Lindenia as a genus of three species, closely related to Wendlandia.

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“…1) is a flavonoid that belongs to the flavonol subgroup. This flavonoid is found in fruits of genus Pouteria (Ma et al, 2004) and Manilkara zapota (Ma et al, 2003), leaves of Eugenia uniflora (Schmeda-Hirschmann et al, 1987), and latex of Croton draco (Tsacheva et al, 2004). In addition, myricitrin has been reported as having an antioxidant action (Edenharder and Grü nhage, 2003).…”

mentioning

confidence: 99%

Analysis of the Antinociceptive Effect of the Flavonoid Myricitrin: Evidence for a Role of the l-Arginine-Nitric Oxide and Protein Kinase C Pathways

Meotti

Luiz²,

Pizzolatti³

et al. 2005

J Pharmacol Exp Ther

148

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The present study investigated the antinociceptive effects of the flavonoid myricitrin in chemical behavioral models of pain in mice and rats. Myricitrin given by i.p. or p.o. routes produced dose-related antinociception when assessed on acetic acidinduced visceral pain in mice. In addition, the i.p. administration of myricitrin exhibited significant inhibition of the neurogenic pain induced by intraplantar (i.pl.) injection of capsaicin. Likewise, myricitrin given by i.p. route reduced the nociception produced by i.pl. injection of glutamate and phorbol myristate acetate (PMA). Western blot analysis revealed that myricitrin treatment fully prevented the protein kinase C (PKC) ␣ and PKC⑀ activation by PMA in mice hind paws. Myricitrin given i.p. also inhibited the mechanical hyperalgesia induced by bradykinin, without affecting similar responses caused by epinephrine and prostaglandin E 2 . The antinociception caused by myricitrin in the acetic acid test was significantly attenuated by i.p. treatment of mice with the nitric oxide precursor, L-arginine. In contrast, myricitrin antinociception was not affected by naloxone (opioid receptor antagonist) or neonatal pretreatment of mice with capsaicin and myricitrin antinociceptive effects is not related to muscle relaxant or sedative action. Together, these results indicate that myricitrin produces pronounced antinociception against chemical and mechanical models of pain in rodents. The mechanisms involved in their actions are not completely understood but seem to involve an interaction with nitric oxide-L-arginine and protein kinase C pathways.

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Complement Inhibiting Properties of Dragon’s Blood from Croton draco

Cited by 17 publications

References 2 publications

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

Chemotaxonomic significance of flavonoids, coumarins and triterpenes of Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, with new insights about its systematic position within the family

Analysis of the Antinociceptive Effect of the Flavonoid Myricitrin: Evidence for a Role of the l-Arginine-Nitric Oxide and Protein Kinase C Pathways

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