Complement in normal and disease processes

Cooper, Neil R.; Fogel, Bernard J.

doi:10.1016/s0022-3476(67)80276-2

Cited by 21 publications

(4 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well known that many of the complement factors, especially C3, C4 and factor B, behave as acute-phase proteins and rise during inflammation (30). This has been reported in experimental inflammation, burn trauma, bacterial infection and after injection of endotoxins (8,24). Inflammatory responses induced by the inhaled organic materials may also be the cause of the increases of complement levels as seen in some of our patients.…”

Section: Discussionsupporting

confidence: 69%

Levels of Complement Factors in Human Serum during Immediate and Late Asthmatic Reactions and during Acute Hypersensitivity Pneumonitis

Baur

Dorsch

Becker

1980

Allergy

View full text Add to dashboard Cite

In 16 asthmatic patients and in four subjects suspected of having hypersensitivity pneumonitis, serum levels of CH50, C3, C4, C5 and factor B were measured before, between 10 and 20 min, between 5 and 7 h and, in the latter group, also 24 h after allergen challenges provoking type I bronchial reactions or acute hypersensitivity pneumonitis. There was a significant decrease in one of the complement factors in two patients during the immediate asthmatic phase, but in no patient during the late asthmatic phase and in no patient with hypersensitivity pneumonitis. On the other hand, significant increases of C3, C4, and/or CH50 were seen in five patients during immediate asthmatic reactions, in seven patients during late asthmatic reactions and in all cases with hypersensitivity pneumonitis. However, with respect to the particular complement factors the vast majority of the patients showed no appreciable change. Investigations of C3 split products, which were done in seven patients gave negative results. No correlations existed between the changes in the levels of complement factors to increases of Raw, decreases of DLCO, size of skin test reactions or RAST scores. The cause and pathophysiological role of the non-uniform behaviour of serum complement levels after inhalation challenges is not yet clear; obviously both consumption and formation of complement factors take place during allergen-induced asthmatic reactions and hypersensitivity pneumonitis.

show abstract

Section: Discussionsupporting

confidence: 69%

Levels of Complement Factors in Human Serum during Immediate and Late Asthmatic Reactions and during Acute Hypersensitivity Pneumonitis

Baur

Dorsch

Becker

1980

Allergy

View full text Add to dashboard Cite

show abstract

“…Levels of C4, C3 and C5 increased during the first six days of infection conforming to the acute phase pattern commonly observed in infectious diseases [11]. Rytel et al (28) reported two cases with decreased C4 and C3 during pneumococcal infection associated with DIC.…”

Section: Discussionsupporting

confidence: 67%

Disseminated Intravascular Coagulopathy during Experimental Pneumococcal Sepsis: Studies in Normal and Asplenic Rhesus Monkeys

Hb¹,

Yamada²,

Df³

et al. 1977

J Med Primatol

View full text Add to dashboard Cite

Disseminated intravascular coagulation (DIC) was induced in both normal and asplenic rhesus monkeys by intravenous challenge with Streptococcus pneumoniae. Our observations in the infected monkeys have led us to conclude that (1) pneumococcal capsular polysaccharide (PCP), immune complexes and complement may not have primary roles in the initiation of DIC; (2) intact pneumococci may be catalysts for the development of DIC ; (3) the initial event in DIC may be activation of Hageman factor ; and (4) evidence of activation of Hageman factor-dependent systems is present regardless of severity of infection.

show abstract

“…Many gram negative bacteria are destroyed by direct combined action of specific antibody and complement; 2. Other --mainly gram positive --bacteria are eliminated in the presence of complement by phagocytosis [3]. This explains the rise in complement activity in early bacterial infection also found in adults [11], Since complement levels usually were determined in the first week of illness it is not known whether raised titres were present during the entire course of the disease In one infant of 3 months we did not find any complement activity at all.…”

Section: Resultsmentioning

confidence: 79%

Haemolytic complement activity in infants

Busse

Ströder

1973

Z. Kinder-Heilk.

View full text Add to dashboard Cite

Abstract. In 111 sera of sick and 30 sera of healthy infants aged 14 days to 12 months hemolytic activity of complement was estimated photometrically as described by Kabat, titres being expressed in 50% hemolytic units (C'H50).In infants hemolytic complement activity is only slightly lower than in adults. Bacterial infections cause a significant rise in complement activity, at least during the initial stage of the disease. In various other diseases (rickets, dyspepsia, viral infections of the upper airways, skin affections) there is normal complement activity as determined by sheep erythroeyte hemolysis in vitro.

show abstract

Complement in normal and disease processes

Cited by 21 publications

References 105 publications

Levels of Complement Factors in Human Serum during Immediate and Late Asthmatic Reactions and during Acute Hypersensitivity Pneumonitis

Levels of Complement Factors in Human Serum during Immediate and Late Asthmatic Reactions and during Acute Hypersensitivity Pneumonitis

Disseminated Intravascular Coagulopathy during Experimental Pneumococcal Sepsis: Studies in Normal and Asplenic Rhesus Monkeys

Haemolytic complement activity in infants

Contact Info

Product

Resources

About