Complement-Fixing Antigens in Burkitt Lymphoma Cell Lines

McCormick, Kenneth J.; Stenback, Wayne A.; Mumford, David M.; Trentin, John J.

doi:10.1128/iai.4.1.20-22.1971

Cited by 2 publications

(6 citation statements)

References 12 publications

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“…The CF activity of extracts from these cultures did not follow the pattern established for the Burkitt cell lines; i.e., the presence of the herpes particle as detected by electron microscopy did not correlate with the presence of CF antigen in the American lines when tested against African sera. However, since Henle's antigen was detected sporadically in the OP cell line, the relationship between the presence of this antigen and CF reactivity was still maintained (7).…”

Section: Resultsmentioning

confidence: 99%

“…Complement-fixing (CF) antigen(s) in extracts from lymphoid cell lines have been described by several investigators (1,3,7,8,13,14,(16)(17)(18). These studies have indicated that humoral antibodies to the antigen(s) are related to infection of the individual by the herpes-like virus present in lymphoid cell cultures.…”

mentioning

confidence: 99%

“…However, the CF antigen(s) may not be identical to Henle's antigen that is detected by indirect immunofluorescence (IF) tests (4). This evidence (3,7,13,14,17,18) includes studies on: (i) sedimentation of the CF antigen(s); (ii) the quantity of the antigen(s) present in an extract compared to the number of cells producing Henle's antigen; (iii) the presence of CF antigen(s) in some virus-free lymphoid cultures; and (iv) the separation of CF antigens by physical means. Our previous work (7,8) suggested a correlation between the presence of the herpes-like virus and the presence of CF antigen(s) in cell cultures from patients with Burkitt's lymphoma.…”

mentioning

confidence: 99%

“…This evidence (3,7,13,14,17,18) includes studies on: (i) sedimentation of the CF antigen(s); (ii) the quantity of the antigen(s) present in an extract compared to the number of cells producing Henle's antigen; (iii) the presence of CF antigen(s) in some virus-free lymphoid cultures; and (iv) the separation of CF antigens by physical means. Our previous work (7,8) suggested a correlation between the presence of the herpes-like virus and the presence of CF antigen(s) in cell cultures from patients with Burkitt's lymphoma. This report describes the correlation between the herpes-like virus and CF antigenicity in several American lymphoid cell lines.…”

mentioning

confidence: 99%

“…In addi- tion, a CF antigen is described which may be related to the presence of genetic material of the herpes-like virus, but which could be differentiated from the antigen(s) of Burkitt lymphoma cells by its serological activity. (7).…”

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confidence: 99%

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Complement-Fixing Antigens in Lymphoid Cell Lines of American Origin

et al. 1972

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Lymphoid cell lines from Americans with infectious mononucleosis (Choate, EH IV, and OP), and from a normal American (Cassio), were tested for presence of herpes-like virus by electron microscopy (EM) and immunofluorescence (IF), and for complement-fixing (CF) antigens, using both American and African sera. Whereas earlier tests of seven African (Burkitt) lymphoma cell lines showed an absolute correlation between presence of herpes-like virus and CF reactivity with either African or American sera, the same was not true of the American cell lines. Herpes-like particles were found in the Cassio line by both EM and IF, and in a few cells of the OP line by IF, but not by EM. The virus was not found in the Choate or EH IV lines by either EM or IF. African sera from either normal individuals or patients with Burkitt lymphoma contained CF antibodies to extracts of Cassio and OP cells. Normal American sera contained CF antibodies to these extracts as well as to extracts of Choate cells. The EH IV cell line did not produce CF antigens detectable with either African or American sera. The data indicate that the CF antigens of the herpes virus-negative Choate cell line were serologically distinct from those in Burkitt lines. However, it is possible that the antigens from both sources are related to the presence of the genome of the herpes-like virus.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Complement-Fixing Antigens in Lymphoid Cell Lines of American Origin

et al. 1972

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Treatment with the antigranulocyte monoclonal antibody RB6-8C5 impairs resistance of mice to gastrointestinal infection with Listeria monocytogenes

1996

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Treatment with the antigranulocyte monoclonal antibody (MAb) RB6-8C5 increased the severity of infection in mice intragastrically inoculated with Listeria monocytogenes. Most MAb RB6-8C5-treated mice died when inoculated intragastrically with as few as 4 ؋ 10 4 L. monocytogenes bacteria, whereas most control mice survived intragastric inoculation with 4 ؋ 10 8 L. monocytogenes bacteria. The increased severity of infection in MAb RB6-8C5-treated mice appeared to result from listerial multiplication in the spleen and liver rather than from local proliferation in the intestinal tract or mesenteric lymph nodes.

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Complement-Fixing Antigens in Burkitt Lymphoma Cell Lines

Cited by 2 publications

References 12 publications

Complement-Fixing Antigens in Lymphoid Cell Lines of American Origin

Complement-Fixing Antigens in Lymphoid Cell Lines of American Origin

Treatment with the antigranulocyte monoclonal antibody RB6-8C5 impairs resistance of mice to gastrointestinal infection with Listeria monocytogenes

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