Complement escape of Candida albicans: Identification and characterization of the yeast surface protein CaCRASP-1 which binds factor H, FHL-1 and plasminogen

Poltermann, Sophia; Kunert, Anja; Zipfel, Peter F.

doi:10.1016/j.molimm.2006.07.193

Cited by 2 publications

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“…Poltermann et al [10] discovered that the yeast Candida albicans binds factor H with its surface protein CaCRASP-1 via the two binding sites SCR 6 2 7 and SCR 19 2 20. Factor H remains active and provides a protection against the complement system.…”

Section: Introductionmentioning

confidence: 99%

Playing ‘hide-and-seek’ with factor H: game-theoretical analysis of a single nucleotide polymorphism

Hummert

Glock

Lang

et al. 2018

J. R. Soc. Interface.

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As a part of the complement system, factor H regulates phagocytosis and helps differentiate between a body's own and foreign cells. Owing to mimicry efforts, some pathogenic microorganisms such as are able to bind factor H on their cell surfaces and, thus, become similar to host cells. This implies that the decision between self and foreign is not clear-cut, which leads to a classification problem for the immune system. Here, two different alleles determining the binding affinity of factor H are relevant. Those alleles differ in the SNP Y402H; they are known to be associated with susceptibility to certain diseases. Interestingly, the fraction of both alleles differs in ethnic groups. The game-theoretical model proposed in this article explains the coexistence of both alleles by a game and investigates the trade-off between pathogen detection and protection of host cells. Further, we discuss the ethnicity-dependent frequencies of the alleles. Moreover, the model elucidates the mimicry efforts by pathogenic microorganisms.

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Section: Introductionmentioning

confidence: 99%