1990
DOI: 10.1016/0016-5085(90)91209-o
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Complement deposits in inflammatory bowel disease

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Cited by 7 publications
(5 citation statements)
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“…The most common site is the pretibial or shin area, but the knees, ankles, arms, or trunk can also be affected (Levine and Burakoff, 2011). Direct immunofluorescence of EN lesions reveal perivascular deposits of immunoglobulins and complement, suggesting that the pathogenesis of reactive cutaneous manifestation of IBD is due to the abnormal immunological response of common antigens between bowel bacteria and skin (Veloso, 1990; Fava and Danese, 2011; Khor et al, 2011). EN lesions have been noted to be correlated with the underlying disease activity and worsened with colitis flares (Timani and Mutasim, 2008).…”
Section: Reactive Cutaneous Manifestations Of Ibdmentioning
confidence: 99%
“…The most common site is the pretibial or shin area, but the knees, ankles, arms, or trunk can also be affected (Levine and Burakoff, 2011). Direct immunofluorescence of EN lesions reveal perivascular deposits of immunoglobulins and complement, suggesting that the pathogenesis of reactive cutaneous manifestation of IBD is due to the abnormal immunological response of common antigens between bowel bacteria and skin (Veloso, 1990; Fava and Danese, 2011; Khor et al, 2011). EN lesions have been noted to be correlated with the underlying disease activity and worsened with colitis flares (Timani and Mutasim, 2008).…”
Section: Reactive Cutaneous Manifestations Of Ibdmentioning
confidence: 99%
“…2 Histological examination of the lower dermis in these patients may reveal a moderate lymphohistiocytic infiltrate, and direct immunofluorescence for immunoglobulins and complement may reveal perivascular deposits. 16 Erythema nodosum lesions usually respond to treatment with corticosteroids, but severe or refractory cases may require infliximab therapy. 17…”
Section: Erythema Nodosummentioning
confidence: 99%
“…42 In the case of pyoderma investigators stress a heightened expression of pro-inflammatory cytokines: IL8, IL16, IL17, tumor necrosis factor (TNF)-alpha. 43 As usual, the influence of a permissive HLA expression is invoked: B15 has been associated to development of erythema nodosum; 44 TRAF3IP2 an intermediate of the inflammatory response and possibly a driver of IL17, has been summoned for both erythema and pyoderma. 45 Unfortunately, a drug acting specifically against IL17 resulted efficacious against rheumatic and cutaneous inflammatory disorders, but a trigger for IBD reaction and new-onset.…”
Section: Skin Manifestationsmentioning
confidence: 99%