Complement-dependent acute immunologic lung injury in an experimental model resembling Goodpasture's syndrome

Mercola, Karen E.; Hagadorn, James E.

doi:10.1016/0014-4800(73)90081-6

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Also, Kilburn (1973) stated that immune complexes, specifically those of anaphylaxis as well as the lipopolysaccharides of endotoxins from virus and gram-negative bacteria, produce pulmonary oedema in rabbits and man. Fluorescent anti-rabbit IgG and fluorescent anti-rat C3 stain alveolar septa and glomeruli in a linear membrane-like pattern, suggesting localization of IgG on either basement membrane or endothelial cells of alveolar capillaries and on basement membrane of glomerular capillaries in rat models of Goodpastures' syndrome (Mercola and Hagadorn, 1973).…”

Section: Discussionmentioning

confidence: 96%

Immune Complexes in Cystic Fibrosis

McFarlane¹,

Holzel²,

Brenchley³

et al. 1975

BMJ

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Section: Discussionmentioning

confidence: 96%

Immune Complexes in Cystic Fibrosis

McFarlane¹,

Holzel²,

Brenchley³

et al. 1975

BMJ

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“…In IHC studies on Goodpasture's syndrome, which is characterized by development of antibodies to alveolar and glomerular basement membrane antigens, IgG and complement (C3) were localized both in alveolar walls in the lung and in glomerular basement membranes of the kidney (189)(190)(191)). An experimental model sharing these features and thus resembling Goodpasture's syndrome was developed by injecting rabbit anti-rat lung serum into normal rats (192). Based on immunofluorescence, Levy et al (193) reported an example of autoimmune disease characterized by the presence of antitubular and antialveolar basement membrane antibodies associated with immune-complex glomerulonephritis.…”

Section: Immunological Reactionsmentioning

confidence: 99%

Immunohistochemical techniques and their applications in the histopathology of the respiratory system.

Linnoila¹,

Petrusz²

1984

Environ Health Perspect

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Subsequent to the first report in the 1940s on incubation of tissue sections with fluorescein-conjugated antibodies for localization of antigens, a great number of modifications were introduced to improve the validity of immunohistochemistry which has become a growingly popular tool. The use of immunoenzymatic techniques eliminates the need for expensive fluorescence microscopy equipment, the lack of permanency of preparations and the lack of electron density required in ultrastructural localization of antigens. Regardless of the technique, it is also important to choose a correct fixation which allows the proper preservation of antigens and morphology and the penetration of antibodies through the entire thickness of the preparation. A variety of immunohistochemical techniques have been applied to study several components of the lung, such as collagen, surface active material, lung specific antigens, and enzymes and the detection of tumor markers, immunoglobulins and infectious agents in the respiratory system which is reviewed. The large surface area and the multiplicity of cell types provided by the respiratory tract epithelium of humans for exposure to microbial as well as toxic substances in the environment make this organ system very vulnerable but a good early indicator of adverse health effects. Immunohistochemistry provides valuable information complementary to the immunochemical and biochemical characterization of this barrier.

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General Pathology of the Transplantation Reaction in Experimental and Clinical Organ Grafts

Jerusalem¹,

Jap²

1977

Transplantation

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Complement-dependent acute immunologic lung injury in an experimental model resembling Goodpasture's syndrome

Cited by 5 publications

References 13 publications

Immune Complexes in Cystic Fibrosis

Immune Complexes in Cystic Fibrosis

Immunohistochemical techniques and their applications in the histopathology of the respiratory system.

General Pathology of the Transplantation Reaction in Experimental and Clinical Organ Grafts

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