Complement C6 and C7 Polymorphisms in Japanese Patients with Chronic Glomerulonephritis

Abstract

C6 and C7 types were studied in 158 Japanese patients with different types of chronic glomerulonephritis: 75 patients with IgA nephropathy (IgA-N); 49 patients with idiopathic membranous nephropathy (IMN), and 34 patients with minimal-change nephrotic syndrome (MCNS). There were significant differences in the C6 and C7 allele and phenotype frequencies between the patient groups and controls. A strong association was found between IgA-N and C7 5 phenotype (p < 0.001, RR = 12.71), and between MCNS and C7 5 phenotype (p < 0.001, RR = 14.20). A significant association between MCNS and C6 B2 phenotype (p < 0.05, RR = 2.42) was also found. In the IMN patient group, a significant association with C7 4 phenotype (p < 0.05, RR = 2.42) was observed. Thus, C6 and C7 phenotypes may be causative factors in the development of chronic glomerulonephritis.

A 425 T>C polymorphism in complement C7 association with resistance to Aeromonas hydrophila in grass carp

“…C7 was first identified in human (DiScipio and Gagnon, 1982). Few studies have examined the association between genetic polymorphisms in C7 and disease traits (Nishimukai et al, 1989;Lian et al, 2012). The grass carp C7 consists of 821 amino acids and is located on linage group 3 (Shen YB, Xu XY and Li JL, unpublished results).…”

Complement Component C6 Polymorphism: Novel Protein-Typing Technique and Distribution of Allotypes in Germany

“…The variation of C6 patterns was revealed by the conventional hemolysis-in-gel assay technique, using C6-deficient rabbit serum and either sheep red cells sensitized by antibody or EAC 143 (Antrypol) after thinlayer polyacrylamide gel isoelectric focusing [12]. In this article, we report on an IEF procedure for the determination of C6 using subsequent direct immunofixation with monospecific C6 antisera.…”