Complement C3 Inhibition Modulates Neurodegeneration in Chronic Traumatic Brain Injury

Boulos, Mary; Bray, Michael J.C.

doi:10.1523/jneurosci.1011-18.2018

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…16 Relatedly, neuroinflammatory markers are chronically elevated in anxiety, with some authors suggesting that anxiety and stress may contribute to post-TBI neurodegeneration through this pathway. 17 Given literature demonstrating the importance of inflammatory processes in dementia progression, earlier anxiety onset in this context is compelling. 18 Recently, anxiety has also been demonstrated to be associated with decline in frontal cognitive function (digit symbol modality, an executive functioning test).…”

Section: Discussionmentioning

confidence: 99%

“…While neurobiological mechanisms underlying this risk warrant further study, previous work suggests post‐TBI neurodegeneration may be driven by neuroinflammatory processes 16 . Relatedly, neuroinflammatory markers are chronically elevated in anxiety, with some authors suggesting that anxiety and stress may contribute to post‐TBI neurodegeneration through this pathway 17 . Given literature demonstrating the importance of inflammatory processes in dementia progression, earlier anxiety onset in this context is compelling 18 .…”

Section: Discussionmentioning

confidence: 99%

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Traumatic brain injury alters neuropsychiatric symptomatology in all‐cause dementia

Bray

Richey

Bryant

et al. 2021

Alzheimer's & Dementia

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Introduction Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians. Methods Incidence of NPS was examined in participants with normal cognition who progressed to all‐cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence across 7.6 ± 3.0 years of follow‐up. Results Participants with TBI history had increased prevalence and incidence of apathy (44.7% vs 29.9%, P = .0062; HRadj. = 1.708, P = .0018) and motor disturbances (17.2% vs 9.5%, P = .0458; HRadj. = 2.023, P = .0168), controlling for demographics and type of dementia diagnosis. Earlier anxiety onset was associated with TBI (692 days prior to dementia diagnosis vs 161 days, P = .0265). Discussion History of TBI is associated with increased risk for and earlier onset of NPS in the trajectory of dementia development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Traumatic brain injury alters neuropsychiatric symptomatology in all‐cause dementia

Bray

Richey

Bryant

et al. 2021

Alzheimer's & Dementia

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“…), 53,54 potentially exacerbating neurodegenerative processes through pro-inflammatory pathways. 55,56 This might contribute to greater yearly decrements in heavyweights despite the greater volume of strikes absorbed by lightweights on a per-fight basis and the possible exacerbations from effects of weight-cutting. Future work is required to elucidate these complex relationships.…”

Section: Discussionmentioning

confidence: 99%

Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters

Bray

Tsai

Bryant

et al. 2021

Neurotrauma Reports

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Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk for repetitive TBI and may provide valuable insight into both the pathophysiology of TBI and its consequences. Currently, effects of fighter weight class on brain volumetrics (regional and total) and functional outcomes are unknown. Fifty-three boxers and 103 MMA fighters participating in the Professional Fighters Brain Health Study (PRBHS) underwent volumetric magnetic resonance imaging (MRI) and neuropsychological testing. Fighters were divided into lightweight (£139.9 lb), middleweight (140.0-178.5 lb), and heavyweight (>178.5 lb). Compared with lightweight fighters, heavyweights displayed greater yearly reductions in regional brain volume (boxers: bilateral thalami; MMA: left thalamus, right putamen) and functional performance (boxers: processing speed, simple and choice reaction; MMA: Trails A and B tests). Lightweights suffered greater reductions in regional brain volume on a per-fight basis (boxers: left thalamus; MMA: right putamen). Heavyweight fighters bore greater yearly burden of regional brain volume and functional decrements, possibly related to differing fight dynamics and force of strikes in this division. Lightweights demonstrated greater volumetric decrements on a per-fight basis. Although more research is needed, greater per-fight decrements in lightweights may be related to practices of weightcutting, which may increase vulnerability to neurodegeneration post-TBI. Observed decrements associated with weight class may result in progressive impairments in fighter performance, suggesting interventions mitigating the burden of TBI in professional fighters may both improve brain health and increase professional longevity.

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“…2b and Fig. 5b) may play a role in the release of C3, which may contribute to neuroinflammation [144][145][146]. Importantly, neuroinflammation around the electrode site may prevent neurons from firing properly or cause them to undergo apoptosis [28,31,45,46].…”

Section: Astrocyte-mediated Alterations In Single-unit Amplitudementioning

confidence: 99%

In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation

Savya

Lam

et al. 2022

Biomaterials

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Complement C3 Inhibition Modulates Neurodegeneration in Chronic Traumatic Brain Injury

Cited by 14 publications

References 20 publications

Traumatic brain injury alters neuropsychiatric symptomatology in all‐cause dementia

Traumatic brain injury alters neuropsychiatric symptomatology in all‐cause dementia

Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters

In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation

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