Complement as a multifaceted modulator of kidney transplant injury

Renal Allograft Fibrosis: Biology and Therapeutic Targets

“…Various complement components are involved in renal allograft damage and fibrosis (81)(82)(83). For example, complement promotes fibrosis and reduces allograft survival in proteinuric and non-proteinuric models of renal fibrosis and kidney transplantation (84)(85)(86)(87)(88)(89).…”

“…For example, complement promotes fibrosis and reduces allograft survival in proteinuric and non-proteinuric models of renal fibrosis and kidney transplantation (84)(85)(86)(87)(88)(89). Several clinical trials targeting the complement system are ongoing in various renal diseases, including renal allografts (81).…”

Target It All Right, But Do Not Forget the Torchbearer

“…Complement deficient mice display limited kidney inflammation whereas mice which lack complement regulators suffer less damage and various complement inhibitors avert damage invariably. 13 Atkinson et al, 10 however, prompt us to consider targeted delivery of complement inhibitors, and the best approach for the kidney, and for other molecules, as well, needs to be defined.…”

Kidney disease: new technologies translate mechanisms to cure

“…Extending graft survival is an important goal, since studies have demonstrated lower mortality (63) and higher quality of life (64) with transplantation compared with dialysis. The role of complement activation as a mediator of graft rejection and long-term graft survival is reviewed in this issue by Paolo Cravedi and Peter Heeger (65). Animal studies have suggested that complement factors elaborated by cells resident in the transplanted organ have an important role in mediating ischemia-reperfusion kidney injury (66).…”