Complement activating ABO anti-A IgM/IgG act synergistically to cause erythrophagocytosis: implications among minor ABO incompatible transfusions

Pandey, Priyanka; Anani, Waseem Q.; Pugh, Tina; Gottschall, Jerome L.; Denomme, Gregory A.

doi:10.1186/s12967-020-02378-w

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Red cell transfusions cause the most extreme reactions, but hemolysis and other reactions can occur when platelets are ABO incompatible. 27 When the red cell is removed by opsonization, the reaction is the least severe for 2 reasons: (1) the cellular debris is retained within the phagocyte, and (2) the complement cascade elicits a less intense inflammatory response. When the reaction continues to development of the terminal cascade, MAC formation occurs, and the inflammatory response will be more powerful.…”

Section: } }mentioning

confidence: 99%

“…Because the antigen cannot be separated, the entire cell is targeted. Red cell transfusions cause the most extreme reactions, but hemolysis and other reactions can occur when platelets are ABO incompatible 27. When the red cell is removed by opsonization, the reaction is the least severe for 2 reasons: (1) the cellular debris is retained within the phagocyte, and (2) the complement cascade elicits a less intense inflammatory response.…”

Section: Complement Systemmentioning

confidence: 99%

See 1 more Smart Citation

The Many Faces of Hemolysis

Cook¹

2023

Journal of Infusion Nursing

View full text Add to dashboard Cite

Hemolysis is a problem associated with a variety of red cell pathologies and physiologies not limited to the transfusion of cells. Various pathways lead to the observed outcomes when a hemolytic event occurs. Each event, and the pathway it follows, is based on characteristics of the red cell, the location in which the hemolysis occurs, and the interaction of the immune system. The severity of an event can be predicted with the knowledge of how these 3 factors interface. Although not all hemolytic events are alike, similarities may exist when the pathways overlap.

show abstract

Section: } }mentioning

confidence: 99%

Section: Complement Systemmentioning

confidence: 99%

The Many Faces of Hemolysis

Cook¹

2023

Journal of Infusion Nursing

View full text Add to dashboard Cite

show abstract

“…It has been reported that ABO blood group-incompatible antibodies, which consist of IgM antibodies that are naturally present and IgG antibodies that are induced upon antigen sensitization, may also influence the survival of transplanted grafts [ 124 ]. In this chapter, the involvement of ABO blood group-incompatible antibodies in transplanted organ survival, as well as the factors that affect this interference, are discussed.…”

Section: Abo Blood Group-incompatible Antibodies In the Field Of Tmentioning

confidence: 99%

Characteristics of Immunoglobulin M Type Antibodies of Different Origins from the Immunologic and Clinical Viewpoints and Their Application in Controlling Antibody-Mediated Allograft Rejection

Matsuda

Hiramitsu

et al. 2020

Pathogens

View full text Add to dashboard Cite

Antibody-mediated allograft rejection (AMR) hinders patient prognosis after organ transplantation. Current studies concerning AMR have mainly focused on the diagnostic value of immunoglobulin G (IgG)-type donor-specific antihuman leukocyte antigen antibodies (DSAs), primarily because of their antigen specificity, whereas the clinical significance of immunoglobulin M (IgM)-type DSAs has not been thoroughly investigated in the context of organ transplantation because of their nonspecificity against antigens. Although consensus regarding the clinical significance and role of IgM antibodies is not clear, as discussed in this review, recent findings strongly suggest that they also have a huge potential in novel diagnostic as well as therapeutic application for the prevention of AMR. Most serum IgM antibodies are known to comprise natural antibodies with low affinity toward antigens, and this is derived from B-1 cells (innate B cells). However, some of the serum IgM-type antibodies reportedly also produced by B-2 cells (conventional B cells). The latter are known to have a high affinity for donor-specific antigens. In this review, we initially discuss how IgM-type antibodies of different origins participate in the pathology of various diseases, directly or through cell surface receptors, complement activation, or cytokine production. Then, we discuss the clinical applicability of B-1 and B-2 cell-derived IgM-type antibodies for controlling AMR with reference to the involvement of IgM antibodies in various pathological conditions.

show abstract

“…IgM and IgG antibodies are the two antibodies which play an important role in transfusion science . [1,2]. Anti-A and anti-B antibodies belonging to individuals of A and B blood group are predominantly IgM type while those of blood group O are predominantly IgG type.…”

Section: Introductionmentioning

confidence: 99%

A Prospective, Observational Study to Assess Effect of DTT Treatment on ABO Isoagglutinin Titers in O Blood Group Donors

Shweta¹,

Prashant²,

Divya³

et al. 2022

Int J Blood Res Disord

View full text Add to dashboard Cite

Background and aims:To determine actual concentration of clinically significant IgG antibodies, there is need to inactivate IgM antibodies. Aim of this study was to study effect of dithiothreitol (DTT) on ABO isoagglutinin titers performed by column agglutination technology (CAT) and conventional tube technique (CTT) and to compare results obtained by DTT treatment. Materials and methods:This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors were included. All samples were consecutively tested by CTT and CAT, before and after DTT treatment (pCTT, pCAT).Results: A total of 2005 donors were included. 295 (14.71%) had inter-observer variation by CTT and 51 (2.54%) had inter-observer variation by CAT. IgG titers were found to be more than IgM titers. Reduction in IgG titers was observed with DTT. Concordance between CTT and pCAT was found to be unsatisfactory. pCTT results showed one-fold higher decrease than pCAT when compared to pre-treatment results. IgG titers for both anti-A and anti-B showed strong correlation between CTT (1+ strength) and pCAT (2+ strength). Comparison between CTT (1+) and CAT (1+, 2+, 3+), pCTT (1+) and CAT (1+, 2+, 3+), pCTT (1+) and pCAT (1+,2+, 3+) was performed using Wilcoxon signed-rank paired test for significance. For all comparisons, test was significant at 1+ and not significant at 3+ end point. Conclusion:There is significant difference between antibody titers estimated using DTT treated and untreated plasma. Use of DTT for ABO isoagglutinin titer estimation is recommended.

show abstract

Complement activating ABO anti-A IgM/IgG act synergistically to cause erythrophagocytosis: implications among minor ABO incompatible transfusions

Cited by 6 publications

References 25 publications

The Many Faces of Hemolysis

The Many Faces of Hemolysis

Characteristics of Immunoglobulin M Type Antibodies of Different Origins from the Immunologic and Clinical Viewpoints and Their Application in Controlling Antibody-Mediated Allograft Rejection

A Prospective, Observational Study to Assess Effect of DTT Treatment on ABO Isoagglutinin Titers in O Blood Group Donors

Contact Info

Product

Resources

About