(Compl)Ex-Th17–T<sub>reg</sub>cell inter-relationship

Obermajer, Nataša; Dahlke, Marc H.

doi:10.1080/2162402x.2015.1040217

Cited by 6 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, chemokine recruitment of Th17 cells primarily involves classical Th17 cells, which subsequently undergo transformation in various directions in response to interactions with the microenvironment through processing and modification. It has been shown that the transdifferentiation of Th17 cells to Th1 cells and Th17 cells to Treg cells are reversible processes ( 146 , 147 ). Additionally, metabolically, transdifferentiated Th17 cells differ from classical Th17 cells.…”

Section: Discussionmentioning

confidence: 99%

Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment

Xing,

Man,

Liu

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Tumor development is closely associated with a complex tumor microenvironment, which is composed of tumor cells, blood vessels, tumor stromal cells, infiltrating immune cells, and associated effector molecules. T helper type 17 (Th17) cells, which are a subset of CD4+ T cells and are renowned for their ability to combat bacterial and fungal infections and mediate inflammatory responses, exhibit context-dependent effector functions. Within the tumor microenvironment, different molecular signals regulate the proliferation, differentiation, metabolic reprogramming, and phenotypic conversion of Th17 cells. Consequently, Th17 cells exert dual effects on tumor progression and can promote or inhibit tumor growth. This review aimed to investigate the impact of various alterations in the tumor microenvironment on the antitumor and protumor effects of Th17 cells to provide valuable clues for the exploration of additional tumor immunotherapy strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment

Xing,

Man,

Liu

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In addition to Treg cells as a wholly immunosuppressive population, changes in Treg and Th17 paradigm have recently been taken into consideration in cancers [ 5 , 6 ]. Recent studies suggest that both Th17 cells and FoxP3 + T cells are able to regulate antitumor responses negatively or positively depending on the microenvironment and type of cancer which have a remarkable effect on the number and function of these cells [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells

Rezalotfi

Solgi

Ebrahimi

2020

Journal of Immunology Research

View full text Add to dashboard Cite

Background. Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. Method. Peripheral blood mononuclear cells were isolated from healthy donors and were cultured with conditioned media of MKN-45 (parental) cells as well as gastrospheres’ conditioned media in the context of mixed lymphocyte reaction and in the presence of anti-CD3/CD28 beads. The proliferation was evaluated using CFSE staining; the percentages of CD4+CD25+FoxP3+ Treg and CD4+IL-17+ Th17 cells and IFN-γ+cells and the production of IL-17, TGF-β, and IL-10 were assessed by flow cytometry and ELISA, respectively. Finally, the cytotoxic potential of induced immune cells was measured by examining the secretion of lactate dehydrogenase from target cells. Results. The results revealed a decreased expansion of PBMCs postexposure to gastrospheres’ conditioned medium which was concomitant with an increased percentage of Th17 and an enhanced Th17 to Treg ratio. The conditioned media of gastrospheres enhanced the secretion of IL-10 and IL-17 and decreased TGF-β. Interestingly, immune cells induced by gastrospheres showed significant cytotoxicity in terms of producing IFN-γ and death induction in target cells. All these changes were related to the upregulation of IL-6, IL-10, and IL-22 in gastrospheres compared to parental cells. Conclusion. Our study showed that the condition media of gastrospheres can potentially induce Th17 with increasing in their cytotoxic effect. Based on our knowledge, the present study is the first study that emphasizes the role of gastrospheres in the induction of antitumor Th17 cells. However, it should be confirmed with complementary studies in vivo.

show abstract

Immunological Treatment in Gastrointestinal Cancers

Callata-Carhuapoma

López

2019

Textbook of Gastrointestinal Oncology

View full text Add to dashboard Cite

(Compl)Ex-Th17–T_regcell inter-relationship

Cited by 6 publications

References 52 publications

Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment

Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment

Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells

Immunological Treatment in Gastrointestinal Cancers

Contact Info

Product

Resources

About

(Compl)Ex-Th17–Tregcell inter-relationship

Cited by 6 publications

References 52 publications

Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment

Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment

Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells

Immunological Treatment in Gastrointestinal Cancers

Contact Info

Product

Resources

About

(Compl)Ex-Th17–T_regcell inter-relationship