Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

Rodríguez-Cisneros, Mariana; Morales-Ruíz, Leslie; Salazar-Gómez, Anuar; Rojas-Rojas, Fernando Uriel; Santos, Paulina Estrada‐de los

doi:10.3390/molecules28041646

Cited by 8 publications

(5 citation statements)

References 151 publications

(166 reference statements)

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“…We speculate that an interaction between the iodine atom and the alkyne bond present on the carbamate scaffold potentiates the activity of IPBC against S. aureus and V. parahaemolyticus. This suggestion is partially supported by the membrane disruption typical of iodine observed in this study and the reported antimicrobial effects of cepacin and caryoynecin, which both contain triple alkyne bonds, against S. aureus , E. coli, and Klebsiella pneumonia 51 .…”

Section: Discussionsupporting

confidence: 75%

Antibacterial and antibiofilm activities of iodinated hydrocarbons against Vibrio parahaemolyticus and Staphylococcus aureus

Faleye,

Lee

et al. 2024

Sci Rep

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Food-related illnesses have become a growing public concern due to their considerable socioeconomic and medical impacts. Vibrio parahaemolyticus and Staphylococcus aureus have been implicated as causative organisms of food-related infections and poisoning, and both can form biofilms which confer antibiotic resistance. Hence, the need for continuous search for compounds with antibiofilm and antivirulence properties. In this study, 22 iodinated hydrocarbons were screened for their antibiofilm activity, and of these, iodopropynyl butylcarbamate (IPBC) was found to effectively control biofilm formation of both pathogens with a MIC of 50 µg/mL which was bactericidal to V. parahaemolyticus and S. aureus. Microscopic studies confirmed IPBC inhibits biofilm formation of both bacteria and also disrupted their mixed biofilm formation. Furthermore, IPBC suppressed virulence activities such as motility and hemolytic activity of V. parahaemolyticus and the cell surface hydrophobicity of S. aureus. It exhibited a preservative potential against both pathogens in a shrimp model. IPBC disrupted the cell membrane of S. aureus and V. parahaemolyticus and differentially affected gene expressions related to biofilm formation and virulence. Additionally, it displayed broad-spectrum antibiofilm activities against other clinically relevant pathogens. These findings indicate IPBC offers a potential means of controlling infections mediated by Vibrio and Staphylococcus biofilms.

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Section: Discussionsupporting

confidence: 75%

Antibacterial and antibiofilm activities of iodinated hydrocarbons against Vibrio parahaemolyticus and Staphylococcus aureus

Faleye,

Lee

et al. 2024

Sci Rep

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“…In the multi-genus complex known as Burkholderia sensu lato , antimicrobial compounds have been reported ( Petrova and Mahenthiralingam, 2022 ; Rodríguez-Cisneros et al, 2023 ). This study primarily compiles the antimicrobial compounds identified in Burkholderia .…”

Section: Introductionmentioning

confidence: 99%

Insights into group-specific pattern of secondary metabolite gene cluster in Burkholderia genus

Kim,

Han,

Lee

et al. 2024

Front. Microbiol.

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Burkholderia is a versatile strain that has expanded into several genera. It has been steadily reported that the genome features of Burkholderia exhibit activities ranging from plant growth promotion to pathogenicity across various isolation areas. The objective of this study was to investigate the secondary metabolite patterns of 366 Burkholderia species through comparative genomics. Samples were selected based on assembly quality assessment and similarity below 80% in average nucleotide identity. Duplicate samples were excluded. Samples were divided into two groups using FastANI analysis. Group A included B. pseudomallei complex. Group B included B. cepacia complex. The limitations of MLST were proposed. The detection of genes was performed, including environmental and virulence-related genes. In the pan-genome analysis, each complex possessed a similar pattern of cluster for orthologous groups. Group A (n = 185) had 14,066 cloud genes, 2,465 shell genes, 682 soft-core genes, and 2,553 strict-core genes. Group B (n = 181) had 39,867 cloud genes, 4,986 shell genes, 324 soft-core genes, 222 core genes, and 2,949 strict-core genes. AntiSMASH was employed to analyze the biosynthetic gene cluster (BGC). The results were then utilized for network analysis using BiG-SCAPE and CORASON. Principal component analysis was conducted and a table was constructed using the results obtained from antiSMASH. The results were divided into Group A and Group B. We expected the various species to show similar patterns of secondary metabolite gene clusters. For in-depth analysis, a network analysis of secondary metabolite gene clusters was conducted, exemplified by BiG-SCAPE analysis. Depending on the species and complex, Burkholderia possessed several kinds of siderophore. Among them, ornibactin was possessed in most Burkholderia and was clustered into 4,062 clans. There was a similar pattern of gene clusters depending on the species. NRPS_04014 belonged to siderophore BGCs including ornibactin and indigoidine. However, it was observed that each family included a similar species. This suggests that, besides siderophores being species-specific, the ornibactin gene cluster itself might also be species-specific. The results suggest that siderophores are associated with environmental adaptation, possessing a similar pattern of siderophore gene clusters among species, which could provide another perspective on species-specific environmental adaptation mechanisms.

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“…Pityriacitrin (23) is a natural marine alkaloid containing β‐carboline moiety was obtained and isolated from a Chinese Burkholderia species NBF227 serving diverse biological functions including anticancer activity (Rodríguez‐Cisneros et al., 2023). Xu et al., (2019) synthesized and designed several pityriactrin derivatives by combining β‐carboline pharmacophore with amide functional group.…”

Section: Marine Alkaloid‐oriented β‐Carboline Analoguesmentioning

confidence: 99%

Anticancer mechanisms of β‐carbolines

Mishra,

Gupta,

Jain

et al. 2024

Chem Biol Drug Des

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Abstractβ‐Carboline nucleus is therapeutically valuable in medicinal chemistry for the treatment of varied number of diseases, most importantly cancer. The potent and wide‐ranging activity of β‐carboline has established them as imperative pharmacological scaffolds especially in the cancer treatment. Numerous derivatives such as Tetrahydro β‐carbolines, metal complexed β‐carbolines, mono, di and tri substituted β‐carbolines have been reported to possess dynamic anticancer activity. These different substituted β‐carboline derivatives had shown different mechanism of action and plays important role in anticancer drug discovery and development. The review is an update of the chemistry of β‐carbolines, both synthetic and natural origin acting through various targets against cancerous cells. In addition to this, studies of multitarget molecules designed by coupling β‐carbolines along with other mechanisms for treatment of neoplasm are also summarized.

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Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

Cited by 8 publications

References 151 publications

Antibacterial and antibiofilm activities of iodinated hydrocarbons against Vibrio parahaemolyticus and Staphylococcus aureus

Antibacterial and antibiofilm activities of iodinated hydrocarbons against Vibrio parahaemolyticus and Staphylococcus aureus

Insights into group-specific pattern of secondary metabolite gene cluster in Burkholderia genus

Anticancer mechanisms of β‐carbolines

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